Miller JD, Carlo WA. Pulmonary complications of mechanical ventilation in neonates. Clin Perinatol. 2008;35:273–81. x-xi

Article  PubMed  Google Scholar 

Pneumonia (Ventilator-associated [VAP] and non-ventilator-associated Pneumonia [PNEU]) Event. 2023.

Thatrimontrichai A, Rujeerapaiboon N, Janjindamai W, Dissaneevate S, Maneenil G, Kritsaneepaiboon S, et al. Outcomes and risk factors of ventilator-associated pneumonia in neonates. World J Pediatr. 2017;13:328–34.

Article  PubMed  Google Scholar 

Cernada M, Brugada M, Golombek S, Vento M. Ventilator-associated pneumonia in neonatal patients: an update. Neonatology. 2014;105:98–107.

Article  PubMed  Google Scholar 

Goerens A, Lehnick D, Buttcher M, Daetwyler K, Fontana M, Genet P, et al. Neonatal ventilator associated pneumonia: a quality improvement initiative focusing on antimicrobial stewardship. Front Pediatr. 2018;6:262.

Article  PubMed  PubMed Central  Google Scholar 

Donowitz LG. Nosocomial infection in neonatal intensive care units. Am J Infect Control. 1989;17:250–7.

Article  CAS  PubMed  Google Scholar 

Harpin VA, Rutter N. Barrier properties of the newborn infant’s skin. J Pediatr. 1983;102:419–25.

Article  CAS  PubMed  Google Scholar 

Carr R, Modi N. Haemopoietic colony stimulating factors for preterm neonates. Arch Dis Child Fetal Neonatal Ed. 1997;76:F128–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kohler PF, Farr RS. Elevation of cord over maternal IgG immunoglobulin: evidence for an active placental IgG transport. Nature. 1966;210:1070–1.

Article  CAS  PubMed  Google Scholar 

Looi K, Evans DJ, Garratt LW, Ang S, Hillas JK, Kicic A, et al. Preterm birth: born too soon for the developing airway epithelium? Paediatr Respir Rev. 2019;31:82–8.

PubMed  Google Scholar 

Berdal JE, Bjornholt J, Blomfeldt A, Smith-Erichsen N, Bukholm G. Patterns and dynamics of airway colonisation in mechanically-ventilated patients. Clin Microbiol Infect. 2007;13:476–80.

Article  PubMed  Google Scholar 

Tan B, Zhang F, Zhang X, Huang YL, Gao YS, Liu X, et al. Risk factors for ventilator-associated pneumonia in the neonatal intensive care unit: a meta-analysis of observational studies. Eur J Pediatr. 2014;173:427–34.

Article  PubMed  Google Scholar 

Oami T, Chihade DB, Coopersmith CM. The microbiome and nutrition in critical illness. Curr Opin Crit Care. 2019;25:145–9.

Article  PubMed  PubMed Central  Google Scholar 

Martin-Loeches I, Dickson R, Torres A, Hanberger H, Lipman J, Antonelli M, et al. The importance of airway and lung microbiome in the critically ill. Crit Care. 2020;24:537.

Article  PubMed  PubMed Central  Google Scholar 

Li H, Song C, Liu D, Ai Q, Yu J. Molecular analysis of biofilms on the surface of neonatal endotracheal tubes based on 16S rRNA PCR-DGGE and species-specific PCR. Int J Clin Exp Med. 2015;8:11075–84.

CAS  PubMed  PubMed Central  Google Scholar 

Wagner BD, Sontag MK, Harris JK, Miller JI, Morrow L, Robertson CE, et al. Prenatal complications are associated with the postnatal airway host response and microbiota in intubated preterm infants. J Matern Fetal Neonatal Med. 2019;32:1499–506.

Article  PubMed  Google Scholar 

Friedland DR, Rothschild MA, Delgado M, Isenberg H, Holzman I. Bacterial colonization of endotracheal tubes in intubated neonates. Arch Otolaryngol Head Neck Surg. 2001;127:525–8.

Article  CAS  PubMed  Google Scholar 

Farhath S, Aghai ZH, Nakhla T, Saslow J, He Z, Soundar S, et al. Pepsin, a reliable marker of gastric aspiration, is frequently detected in tracheal aspirates from premature ventilated neonates: relationship with feeding and methylxanthine therapy. J Pediatr Gastroenterol Nutr. 2006;43:336–41.

Article  CAS  PubMed  Google Scholar 

Lopriore E, Markhorst DG, Gemke RJ. Ventilator-associated pneumonia and upper airway colonisation with Gram negative bacilli: the role of stress ulcer prophylaxis in children. Intensive Care Med. 2002;28:763–7.

Article  PubMed  Google Scholar 

Albert BD, Zurakowski D, Bechard LJ, Priebe GP, Duggan CP, Heyland DK, et al. Enteral Nutrition and Acid-Suppressive Therapy in the PICU: Impact on the Risk of Ventilator-Associated Pneumonia. Pediatr Crit Care Med. 2016;17:924–9.

Article  PubMed  PubMed Central  Google Scholar 

Rouze A, Jaillette E, Nseir S. Relationship between microaspiration of gastric contents and ventilator-associated pneumonia. Ann Transl Med. 2018;6:428.

Article  PubMed  PubMed Central  Google Scholar 

Alriyami A, Kiger JR, Hooven TA. Ventilator-Associated Pneumonia in the Neonatal Intensive Care Unit. Neoreviews. 2022;23:e448–e61.

Article  PubMed  Google Scholar 

El Abiad MT RA, Nader N, Yu W, Lakshminrusimha S, Kumar VH, Blessing-Hanagan K, et al. Tracheal pepsin activity in intubated very low birth weight (VLBW) infants. Pediatric Acad Soc 2006.

Prescott HC, O’Brien JM. Prevention of ventilator-associated pneumonia in adults. F1000 Med Rep. 2010;2:15.

Garland JS. Strategies to prevent ventilator-associated pneumonia in neonates. Clin Perinatol. 2010;37:629–43.

Article  PubMed  Google Scholar 

Feldman C, Kassel M, Cantrell J, Kaka S, Morar R, Goolam Mahomed A, et al. The presence and sequence of endotracheal tube colonization in patients undergoing mechanical ventilation. Eur Respir J. 1999;13:546–51.

Article  CAS  PubMed  Google Scholar 

Pan Y, Song S, Tang X, Ai Q, Zhu D, Liu Z, et al. Streptococcus sp. in neonatal endotracheal tube biofilms is associated with ventilator-associated pneumonia and enhanced biofilm formation of Pseudomonas aeruginosa PAO1. Sci Rep. 2017;7:3423.

Article  PubMed  PubMed Central  Google Scholar 

Ventilator-Associated Event (VAE). National Healthcare Safety Network, Centers for Disease Control and Prevention.

Tripathi S MG, Jain A, Kohli N. Study of ventilator associated pneumonia in neonatal intensive care unit: characteristics, risk factors and outcome. Internet J Med Update-EJOURNAL. 2010;5:12–19.

Morris AC, Kefala K, Simpson AJ, Wilkinson TS, Everingham K, Kerslake D, et al. Evaluation of the effect of diagnostic methodology on the reported incidence of ventilator-associated pneumonia. Thorax. 2009;64:516–22.

Article  PubMed  Google Scholar 

Dancer SJ, Coyne M, Robertson C, Thomson A, Guleri A, Alcock S. Antibiotic use is associated with resistance of environmental organisms in a teaching hospital. J Hosp Infect. 2006;62:200–6.

Article  CAS  PubMed  Google Scholar 

Langston SJ, Pithia N, Sim MS, Garg M, de St Maurice A, Chu A. Lack of utility of tracheal aspirates in the management of suspected pneumonia in intubated neonates. Infect Control Hosp Epidemiol. 2020;41:660–5.

Article  PubMed  Google Scholar 

Cernada M, Aguar M, Brugada M, Gutierrez A, Lopez JL, Castell M, et al. Ventilator-associated pneumonia in newborn infants diagnosed with an invasive bronchoalveolar lavage technique: a prospective observational study. Pediatr Crit Care Med. 2013;14:55–61.

Article  PubMed  Google Scholar 

Liao CC, Tsai MH, Lai SH, Lai MY, Chu SM, Huang HR, et al. Safety and clinical application of nonbronchoscopic bronchoalveolar lavage in preterm neonates with clinical ventilator-associated pneumonia. Pediatr Neonatol. 2021;62:195–201.

Article  PubMed  Google Scholar 

Dell’Orto V, Bourgeois-Nicolaos N, Rouard C, Romain O, Shankar-Aguilera S, Doucet-Populaire F, et al. Cell Count Analysis from Nonbronchoscopic Bronchoalveolar Lavage in Preterm Infants. J Pediatr. 2018;200:30–7.e2.

Article  PubMed  Google Scholar 

D’Angio CT, Maniscalco WM, Ryan RM, Avissar NE, Basavegowda K, Sinkin RA. Vascular endothelial growth factor in pulmonary lavage fluid from premature infants: effects of age and postnatal dexamethasone. Biol Neonate. 1999;76:266–73.

Article  PubMed  Google Scholar 

LoMonaco MB, Barber CM, Sinkin RA. Differential cytokine mRNA expression by neonatal pulmonary cells. Pediatr Res. 1996;39:248–52.

Article  CAS  PubMed  Google Scholar 

Mourani PM, Harris JK, Sontag MK, Robertson CE, Abman SH. Molecular identification of bacteria in tracheal aspirate fluid from mechanically ventilated preterm infants. PLoS One. 2011;6:e25959.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fritz CQ, Edwards KM, Self WH, Grijalva CG, Zhu Y, Arnold SR, et al. Prevalence, risk factors, and outcomes of bacteremic pneumonia in children. Pediatrics. 2019;144.e20183090

Apisarnthanarak A, Holzmann-Pazgal G, Hamvas A, Olsen MA, Fraser VJ. Ventilator-associated pneumonia in extremely preterm neonates in a neonatal intensive care unit: characteristics, risk factors, and outcomes. Pediatrics. 2003;112:1283–9.

Article  PubMed  Google Scholar 

Wang HC, Tsai MH, Chu SM, Liao CC, Lai MY, Huang HR, et al. Clinical characteristics and outcomes of neonates with polymicrobial ventilator-associated pneumonia in the intensive care unit. BMC Infect Dis. 2021;21:965.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kaufman D, Fairchild KD. Clinical microbiology of bacterial and fungal sepsis in very-low-birth-weight infants. Clin Microbiol Rev. 2004;17:638–80.

Article  PubMed  PubMed Central  Google Scholar 

Pradeepkumar VK, Rajadurai VS, Tan KW. Congenital candidiasis: varied presentations. J Perinatol. 1998;18:311–6.

CAS  PubMed