Bourget-Murray J, Azad M, Gofton W, Abdelbary H, Garceau S, Grammatopoulos G (2023) Is the routine use of local antibiotics in the management of periprosthetic joint infections justified? Hip Int J Clin Exp Res Hip Pathol Therapy 33(1):4–16. https://doi.org/10.1177/11207000221139467

Article  Google Scholar 

Steadman W, Chapman PR, Schuetz M, Schmutz B, Trampuz A, Tetsworth K (2023) Local antibiotic delivery options in prosthetic joint infection. Antibiot (Basel, Switzerl) 12(4):752. https://doi.org/10.3390/antibiotics12040752

Article  CAS  Google Scholar 

Nelson CL, Evans RP, Blaha JD, Calhoun J, Henry SL, Patzakis MJ (1993) A comparison of gentamicin-impregnated polymethylmethacrylate bead implantation to conventional parenteral antibiotic therapy in infected total hip and knee arthroplasty. Clin Orthop Relat Res 295:96–101

Article  Google Scholar 

Stockley I, Mockford BJ, Hoad-Reddick A, Norman P (2008) The use of two-stage exchange arthroplasty with depot antibiotics in the absence of long-term antibiotic therapy in infected total hip replacement. J Bone Joint Surg Br 90(2):145–148. https://doi.org/10.1302/0301-620X.90B2.19855

Article  CAS  PubMed  Google Scholar 

Hart WJ, Jones RS (2006) Two-stage revision of infected total knee replacements using articulating cement spacers and short-term antibiotic therapy. J Bone Joint Surg Br 88(8):1011–1015. https://doi.org/10.1302/0301-620X.88B8.17445

Article  CAS  PubMed  Google Scholar 

Abosala A, Ali M (2020) The Use of calcium sulphate beads in periprosthetic joint infection, a systematic review. J Bone Joint Infect 5(1):43–49. https://doi.org/10.7150/jbji.41743

Article  Google Scholar 

Howlin RP, Brayford MJ, Webb JS, Cooper JJ, Aiken SS, Stoodley P (2015) Antibiotic-loaded synthetic calcium sulfate beads for prevention of bacterial colonization and biofilm formation in periprosthetic infections. Antimicrob Agents Chemother 59(1):111–120. https://doi.org/10.1128/AAC.03676-14

Article  CAS  PubMed  Google Scholar 

Reinisch K, Schläppi M, Meier C, Wahl P (2022) Local antibiotic treatment with calcium sulfate as carrier material improves the outcome of debridement, antibiotics, and implant retention procedures for periprosthetic joint infections after hip arthroplasty—a retrospective study. J Bone Joint Infection 7(1):11–21. https://doi.org/10.5194/jbji-7-11-2022

Article  CAS  Google Scholar 

Anguita-Alonso P, Rouse MS, Piper KE, Jacofsky DJ, Osmon DR, Patel R (2006) Comparative study of antimicrobial release kinetics from polymethylmethacrylate. Clin Orthop Relat Res 445:239–244. https://doi.org/10.1097/01.blo.0000201167.90313.40

Article  PubMed  Google Scholar 

McLaren RL, McLaren AC, Vernon BL (2008) Generic tobramycin elutes from bone cement faster than proprietary tobramycin. Clin Orthop Relat Res 466(6):1372–1376. https://doi.org/10.1007/s11999-008-0199-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schwarz EM, McLaren AC, Sculco TP, Brause B, Bostrom M, Kates SL, Parvizi J, Alt V, Arnold WV, Carli A, Chen AF, Choe H, Coraça-Huber DC, Cross M, Ghert M, Hickok N, Jennings JA, Joshi M, Metsemakers WJ, Ninomiya M (2021) Adjuvant antibiotic-loaded bone cement: concerns with current use and research to make it work. J Orthopaedic Res 39(2):227–239. https://doi.org/10.1002/jor.24616

Article  CAS  Google Scholar 

van de Belt H, Neut D, Uges DR, Schenk W, van Horn JR, van der Mei HC, Busscher HJ (2000) Surface roughness, porosity and wettability of gentamicin-loaded bone cements and their antibiotic release. Biomaterials 21(19):1981–1987. https://doi.org/10.1016/s0142-9612(00)00082-x

Article  PubMed  Google Scholar 

van de Belt H, Neut D, Schenk W, van Horn JR, van der Mei HC, Busscher HJ (2000) Gentamicin release from polymethylmethacrylate bone cements and Staphylococcus aureus biofilm formation. Acta Orthop Scand 71(6):625–629. https://doi.org/10.1080/000164700317362280

Article  PubMed  Google Scholar 

Samuel S, Mathew BS, Veeraraghavan B, Fleming DH, Chittaranjan SB, Prakash JA (2012) In vitro study of elution kinetics and bio-activity of meropenem-loaded acrylic bone cement. J Orthopaed Traumatol 13(3):131–136. https://doi.org/10.1007/s10195-012-0191-1

Article  Google Scholar 

Gasparini G, De Gori M, Calonego G, Della Bora T, Caroleo B, Galasso O (2014) Drug elution from high-dose antibiotic-loaded acrylic cement: a comparative, in vitro study. Orthopedics 37(11):e999–e1005. https://doi.org/10.3928/01477447-20141023-57

Article  PubMed  Google Scholar 

Johnson JD, Nessler JM, Horazdovsky RD, Vang S, Thomas AJ, Marston SB (2017) Serum and wound vancomycin levels after intrawound administration in primary total joint arthroplasty. J Arthroplasty 32(3):924–928. https://doi.org/10.1016/j.arth.2015.10.015

Article  PubMed  Google Scholar 

Tkhilaishvili T, Winkler T, Müller M, Perka C, Trampuz A (2019) Bacteriophages as adjuvant to antibiotics for the treatment of periprosthetic joint infection caused by multidrug-resistant Pseudomonas aeruginosa. Antimicrob Agents Chemother 64(1):e00924-e1019. https://doi.org/10.1128/AAC.00924-19

Article  PubMed  PubMed Central  Google Scholar 

Ferry T, Leboucher G, Fevre C, Herry Y, Conrad A, Josse J, Batailler C, Chidiac C, Medina M, Lustig S, Laurent F (2018) Salvage debridement, antibiotics and implant retention (“DAIR”) with local injection of a selected cocktail of bacteriophages: is it an option for an elderly patient with relapsing Staphylococcus aureus Prosthetic-Joint Infection? Open Forum Infect Dis 5(11):269. https://doi.org/10.1093/ofid/ofy269

Article  CAS  Google Scholar 

Ferry T, Batailler C, Souche A, Cassino C, Chidiac C, Perpoint T, le Corvaisier C, Josse J, Gaillard R, Roger J, Kolenda C, Lustig S, Laurent F (2021) Arthroscopic “debridement and implant retention” with local administration of exebacase (Lysin CF-301) followed by suppressive tedizolid as salvage therapy in elderly patients for relapsing multidrug-resistant S. Epidermidis prosthetic knee infection. Front Med 8:550853. https://doi.org/10.3389/fmed.2021.550853

Article  Google Scholar 

Ferry T, Kolenda C, Batailler C, Gustave CA, Lustig S, Malatray M, Fevre C, Josse J, Petitjean C, Chidiac C, Leboucher G, Laurent F (2020) Phage therapy as adjuvant to conservative surgery and antibiotics to salvage patients with relapsing S. aureus prosthetic knee infection. Front Med 7:570572. https://doi.org/10.3389/fmed.2020.570572

Article  Google Scholar 

Gibb BP, Hadjiargyrou M (2021) Bacteriophage therapy for bone and joint infections. Bone Joint J 103(2):234–244. https://doi.org/10.1302/0301-620X.103B2.BJJ-2020-0452.R2

Article  PubMed  Google Scholar 

Lloyd KC, Stover SM, Pascoe JR, Baggot JD, Kurpershoek C, Hietala S (1988) Plasma and synovial fluid concentrations of gentamicin in horses after intra-articular administration of buffered and unbuffered gentamicin. Am J Vet Res 49(5):644–649

CAS  PubMed  Google Scholar 

Schneider RK (1988) Treatment of posttraumatic septic arthritis. In: AAEP Proc, vol 44, p 167

Adams SB, Lescun TB (2000) How to treat septic joints with constant intra-articular infusion of gentamicin or amikacin. In: AAEP Proc, vol 46, pp 188–192

Werner LA, Hardy J, Bertone AL (2003) Bone gentamicin concentration after intra-articular injection or regional intravenous perfusion in the horse. Vet Surg 32(6):559–565. https://doi.org/10.1111/j.1532-950x.2003.00559.x

Article  PubMed  Google Scholar 

Davenport K, Traina S, Perry C (1991) Treatment of acutely infected arthroplasty with local antibiotics. J Arthroplasty 6(2):179–183. https://doi.org/10.1016/s0883-5403(11)80014-8

Article  CAS  PubMed  Google Scholar 

Perry CR, Hulsey RE, Mann FA, Miller GA, Pearson RL (1992) Treatment of acutely infected arthroplasties with incision, drainage, and local antibiotics delivered via an implantable pump. Clin Orthop Relat Res 281:216–223

Article  Google Scholar 

Shaw JA (1995) The use of long-term indwelling catheters for local antibiotic administration into infected joints. J Orthop Tech 3:181–184

Google Scholar 

Roy ME, Peppers MP, Whiteside LA, Lazear RM (2014) Vancomycin concentration in synovial fluid: direct injection into the knee vs intravenous infusion. J Arthroplasty 29(3):564–568. https://doi.org/10.1016/j.arth.2013.08.017

Article  PubMed  Google Scholar 

Zimmerli W, Trampuz A, Ochsner PE (2004) Prosthetic-joint infections. N Engl J Med 351(16):1645–1654. https://doi.org/10.1056/NEJMra040181

Article  CAS  PubMed  Google Scholar 

Whiteside LA, Peppers M, Nayfeh TA, Roy ME (2011) Methicillin-resistant Staphylococcus aureus in TKA treated with revision and direct intra-articular antibiotic infusion. Clin Orthop Relat Res 469(1):26–33. https://doi.org/10.1007/s11999-010-1313-9

Article  PubMed  Google Scholar 

Whiteside LA, Nayfeh TA, LaZear R, Roy ME (2012) Reinfected revised TKA resolves with an aggressive protocol and antibiotic infusion. Clin Orthop Relat Res 470(1):236–243. https://doi.org/10.1007/s11999-011-2087-4

Article  PubMed  Google Scholar 

Fukagawa S, Matsuda S, Miura H, Okazaki K, Tashiro Y, Iwamoto Y (2010) High-dose antibiotic infusion for infected knee prosthesis without implant removal. J Orthopaed Sci 15(4):470–476. https://doi.org/10.1007/s00776-010-1487-8

Article  Google Scholar 

Whiteside LA, Roy ME (2017) One-stage revision with catheter infusion of intraarticular antibiotics successfully treats infected THA. Clin Orthop Relat Res 475(2):419–429. https://doi.org/10.1007/s11999-016-4977-y

Article  PubMed  Google Scholar 

Antony SJ, Westbrook RS, Jackson JS, Heydemann JS, Nelson JL (2015) Efficacy of single-stage revision with aggressive debridement using intra-articular antibiotics in the treatment of infected joint prosthesis. Infect Dis 8:17–23. https://doi.org/10.4137/IDRT.S26824

Article  Google Scholar 

Ji B, Li G, Zhang X, Wang Y, Mu W, Cao L (2020) Effective treatment of single-stage revision using intra-articular antibiotic infusion for culture-negative prosthetic joint infection. Bone Joint J 102(3):336–344. https://doi.org/10.1302/0301-620X.102B3.BJJ-2019-0820.R1

Article  PubMed  Google Scholar 

Li Y, Zhang X, Guo X, Wulamu W, Yushan N, Ji B, Cao L (2022) Effective treatment of single-stage revision using intra-articular antibiotic infusion for polymicrobial periprosthetic joint infection. J Arthroplasty 37(1):156–161. https://doi.org/10.1016/j.arth.2021.09.022

Article  PubMed  Google Scholar 

Li Y, Zhang X, Ji B, Wulamu W, Yushan N, Guo X, Cao L (2023) One-stage revision using intra-articular carbapenem infusion effectively treats chronic periprosthetic joint infection caused by Gram-negative organisms. Bone Joint J 105(3):284–293.