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metadata.dc.identifier.doi: https://doi.org/10.56042/ijeb.v62i05.3890Title: Effect of Nigella sativa L. extract and thymoquinone on the genes responsible for cell proliferation, migration and NK cell cytotoxicity in breast cancerAuthors: Korak, Tuğcan
Emrence, Zeliha
Ekmekci, Sema Sırma
Abacı, Neslihan
Ergül, EmelKeywords: Anticancer;Black cumin;KalonjiIssue Date: May-2024Publisher: NIScPR-CSIR, IndiaAbstract: The black cumin, Nigella sativa L. is known to be effective against various diseases including cancer. Thymoquinone (TQ), active ingredient of N. sativa extracts, can inhibit proliferation metastasis and regulating immune system in different cancers as with breast cancer (BC). The mechanisms of action behind TQ are not clearly understood yet. The purpose of the current study is to investigate the effects of TQ, water (WE) and alcohol extracts (AE) of N. sativa on BC cells by focusing attention on the following genes; CDK4, MYC, NF-κB1, VEGFA, FGF1, N-cadherin, ULBP1, ULBP2 and CD155. Conventional protocols were performed in order to obtain extracts. Cell viability was measured by RTCA and MTT assay, and gene expressions were analyzed by qRT-PCR. Association was significant for CDK4 (P =0.07), MYC (P Page(s): 317-325ISSN: 0975-1009 (Online); 0019-5189 (Print)Appears in Collections:IJEB Vol.62(05) [May 2024]

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