In recent years, patients have been wounded by fires, mechanical injuries and surgery. As the number of such patients increases, wound healing has become a research hotspot in today's society. With the continuous development and application of nano platforms, nanomimic organisms have played a good therapeutic effect in various acute and chronic diseases. However, it has been reported in the literature that the existing nanoplatform technology has limited therapeutic ability for skin wound healing. For instance, the angiogenic and anti-microbial effects of gold nanoparticles and cerium oxide nanoparticles and the antioxidant effects of Prussian Blue（PB） nanoparticle hydrogels, but their poor biocompatibility limits their application. Thus, based on the anti-inflammatory properties of PB, we synthesized a novel nanomaterial—biotinylated liposomes (Lipos) loaded with PB (named PB@Lipo). The results showed that biotinylated liposomes tremendously improved the biocompatibility and stability of PB. Additionally, studies have demonstrated that excessive inflammation leads to a significant delay in wound healing. Applying to skin wounds, PB@Lipo effectively regulates the balance of macrophage pro-inflammatory phenotype (M1) and anti-inflammatory phenotype (M2) to exert anti-inflammatory properties. Meantime, PB@Lipo can promote the production of collagen deposition-related factors, such as collagen type 1 (COL-1) and collagen type 3 (COL-3), which ultimately effectively accelerates wound healing. In general, well-designed new nanomaterials are expected to be a potential treatment for the skin defects, which have excellent anti-inflammatory properties, high biocompatibility and stability.