Optimizing Input Selection for Cardiac Model Training and Inference: An Efficient 3D CNN-based Approach to Automate Coronary Angiogram Video Selection

Abstract

Background: Research leveraging deep learning (DL) for medical image analysis is increasingly using dynamic coronary angiography from cardiac catheterizations to train neural networks. Yet, an efficient, automatic method to select appropriate dynamic images for training is still largely missing. Methods: We developed DL models using 254 coronary angiographic studies from the Mayo Clinic. We utilized two state-of-the-art Convolutional Neural Networks (CNN: ResNet and X3D), to identify low quality angiograms through binary classification (satisfactory/unsatisfactory). Ground truth for the quality of the input angiogram was determined by two experienced cardiologists. We validated the developed model in an independent dataset of 3,208 procedures from 3 Mayo sites. Results: 3D-CNN models outperformed their 2D counterparts, with the X3D model achieving superior performance across all metrics (AUC 0.98, precision 0.86, and sensitivity 0.89). The 2D models processed the video clips faster than 3D models. Despite having a 3D architecture, the X3D model had lower computational demand (2.56 GMAC) and parameter count (2.98 M) than 2D models. When validating models on the independent dataset, slight decreases in AUC and sensitivity were observed but accuracy and specificity remained robust (0.88 and 0.89, respectively for the X3D model). Conclusion: We developed a rapid and effective method for automating the selection of coronary angiogram video clips using 3D-CNNs, potentially improving model accuracy and efficiency in clinical applications. The X3D-S model demonstrates a balanced trade-off between computational efficiency and complexity, making it suitable for real-life clinical applications.

Competing Interest Statement

The authors have declared no competing interest.

Funding Statement

This study did not receive any funding

Author Declarations

I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

Yes

The details of the IRB/oversight body that provided approval or exemption for the research described are given below:

Ethics committee/IRB of Mayo Clinic gave ethical approval for this work.

I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals.

Yes

I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).

Yes

I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable.

Yes

Data Availability

All data produced in the present study are available upon reasonable request to the authors.

留言 (0)

沒有登入
gif