Wu, Q., Luo, X., Xiong, Y., Liu, G., Wang, J., Chen, X., & Mi, B. (2020). Platelet-rich plasma versus hyaluronic acid in knee osteoarthritis: A meta-analysis with the consistent ratio of injection. Journal of Orthopaedic Surgery (Hong Kong)., 28(1), 2309499019887660.

PubMed  Google Scholar 

Patel, S., Dhillon, M. S., Aggarwal, S., Marwaha, N., & Jain, A. (2013). Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis: A prospective, double-blind, randomized trial. American Journal of Sports Medicine, 41(2), 356–364.

Article  PubMed  Google Scholar 

Shahid, M., & Kundra, R. (2017). Platelet-rich plasma (PRP) for knee disorders. EFORT Open Reviews, 2(1), 28–34.

Article  PubMed  PubMed Central  Google Scholar 

Lana, J. F. S. D., Weglein, A., Sampson, S. E., Vicente, E. F., Huber, S. C., Souza, C. V., Lana, J. F. S. D., Weglein, A., Sampson, S. E., Vicente, E. F., Huber, S. C., Souza, C. V., Ambach, M. A., Vincent, H., Urban-Paffaro, A., Onodera, C. M., & Annichino-Bizzacchi, J. M. (2016). Randomized controlled trial comparing hyaluronic acid, platelet-rich plasma and the combination of both in the treatment of mild and moderate osteoarthritis of the knee. Journal of Stem Cells & Regenerative Medicine, 12(2), 69–78.

Article  Google Scholar 

Drengk, A., Zapf, A., Stürmer, E. K., Stürmer, K. M., & Frosch, K. H. (2009). Influence of platelet-rich plasma on chondrogenic differentiation and proliferation of chondrocytes and mesenchymal stem cells. Cells Tissues Organs, 189(5), 317–326.

Article  PubMed  Google Scholar 

Filardo, G., Previtali, D., Napoli, F., Candrian, C., Zaffagnini, S., & Grassi, A. (2021). PRP injections for the treatment of knee osteoarthritis: A meta-analysis of randomized controlled trials. Cartilage, 13(1 Suppl), 364S–375S.

Article  PubMed  Google Scholar 

Kanwat, H., Singh, D. M., Kumar, C. D., Alka, B., Biman, S., & Aman, H. (2018). The effect of intra-articular allogenic platelet rich plasma in Dunkin-Hartley guinea pig model of knee osteoarthritis. Muscles, Ligaments and Tendons Journal, 7(3), 426–434.

Article  PubMed  PubMed Central  Google Scholar 

Boffa, A., Salerno, M., Merli, G., De Girolamo, L., Laver, L., Magalon, J., Sánchez, M., Tischer, T., & Filardo, G. (2021). Platelet-rich plasma injections induce disease-modifying effects in the treatment of osteoarthritis in animal models. Knee Surgery, Sports Traumatology, Arthroscopy, 29(12), 4100–4121.

Article  PubMed  Google Scholar 

Araya, N., Miyatake, K., Tsuji, K., Katagiri, H., Nakagawa, Y., Hoshino, T., Onuma, H., An, S., Nishio, H., Saita, Y., & Sekiya, I. (2020). Intra-articular injection of pure platelet-rich plasma is the most effective treatment for joint pain by modulating synovial inflammation and calcitonin gene-related peptide expression in a rat arthritis model. The American Journal of Sports Medicine, 48(8), 2004–2012.

Article  PubMed  Google Scholar 

Huang, G., Hua, S., Yang, T., Ma, J., Yu, W., & Chen, X. (2018). Platelet-rich plasma shows beneficial effects for patients with knee osteoarthritis by suppressing inflammatory factors. Experimental and Therapeutic Medicine, 15(3), 3096–3102.

CAS  PubMed  PubMed Central  Google Scholar 

Dai, W. L., Zhou, A. G., Zhang, H., & Zhang, J. (2017). Efficacy of platelet-rich plasma in the treatment of knee osteoarthritis: A meta-analysis of randomized controlled trials. Arthroscopy: The Journal of Arthroscopic & Related Surgery: Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 33(3), 659.e1–670.e1.

Google Scholar 

Cope, P. J., Ourradi, K., Li, Y., & Sharif, M. (2019). Models of osteoarthritis: The good, the bad and the promising. Osteoarthritis Cartilage, 27(2), 230–239.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Halpern, B., Chaudhury, S., Rodeo, S. A., Hayter, C., Bogner, E., Potter, H. G., & Nguyen, J. (2013). Clinical and MRI outcomes after platelet-rich plasma treatment for knee osteoarthritis. Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine, 23(3), 238–239.

Article  PubMed  Google Scholar 

Kwon, D. R., Park, G. Y., & Lee, S. U. (2012). The effects of intra-articular platelet-rich plasma injection according to the severity of collagenase-induced knee osteoarthritis in a rabbit model. Annals of Rehabilitation Medicine, 36(4), 458–465.

Article  PubMed  PubMed Central  Google Scholar 

Patel, S., Mishra, N. P., Chouhan, D. K., Nahar, U., & Dhillon, M. S. (2022). Chondroprotective effects of multiple PRP injections in osteoarthritis by apoptosis regulation and increased aggrecan synthesis- Immunohistochemistry based Guinea pig study. Journal of Clinical Orthopaedics and Trauma, 25, 101762.

Article  PubMed  PubMed Central  Google Scholar 

Onul, A., Colvard, M. D., Paradise, W. A., Elseth, K. M., Vesper, B. J., Gouvas, E., Deliu, Z., Garcia, K. D., Pestle, W. J., & Radosevich, J. A. (2012). Application of immunohistochemical staining to detect antigen destruction as a measure of tissue damage. The Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society, 60(9), 683–693.

Article  PubMed  Google Scholar 

Bansal, T., Patel, S., Chouhan, D. K., Bhatia, A., Medhi, B., Kakkar, N., & Singh Dhillon, M. (2020). Adding injectable chitosan poloxamer to platelet rich plasma (PRP) has no beneficial effect in knee OA. A prospective experimental study in Guinea pigs. Muscles, Ligaments & Tendons Journal (MLTJ), 10(4), 568–578.

Article  Google Scholar 

Lin, F., & Chen, Z. (2014). Standardization of diagnostic immunohistochemistry: Literature review and geisinger experience. Archives of Pathology and Laboratory Medicine, 138(12), 1564–1577.

Article  PubMed  Google Scholar 

Liu, X., Wang, L., Ma, C., Wang, G., Zhang, Y., & Sun, S. (2019). Exosomes derived from platelet-rich plasma present a novel potential in alleviating knee osteoarthritis by promoting proliferation and inhibiting apoptosis of chondrocyte via Wnt/β-catenin signaling pathway. Journal of Orthopaedic Surgery, 14(1), 470.

Article  Google Scholar 

López-Franco, M., López-Franco, O., Murciano-Antón, M. A., Cañamero-Vaquero, M., Fernández-Aceñero, M. J., Herrero-Beaumont, G., & Gómez-Barrena, E. (2016). Meniscal degeneration in human knee osteoarthritis: in situ hybridization and immunohistochemistry study. Archives of Orthopaedic and Trauma Surgery, 136(2), 175–183.

Article  PubMed  Google Scholar 

Bendele, A. M., & Hulman, J. F. (1988). Spontaneous cartilage degeneration in guinea pigs. Arthritis and Rheumatism, 31(4), 561–565.

Article  CAS  PubMed  Google Scholar 

Musci, R. V., Walsh, M. A., Konopka, A. R., Wolff, C. A., Peelor, F. F., Reiser, R. F., Santangelo, K. S., & Hamilton, K. L. (2020). The Dunkin Hartley Guinea pig is a model of primary osteoarthritis that also exhibits early onset myofiber remodeling that resembles human musculoskeletal aging. Frontiers in Physiology, 11, 571372.

Article  PubMed  PubMed Central  Google Scholar 

Kuyinu, E. L., Narayanan, G., Nair, L. S., & Laurencin, C. T. (2016). Animal models of osteoarthritis: Classification, update, and measurement of outcomes. Journal of Orthopaedic Surgery, 2(11), 19.

Article  Google Scholar 

Kikuchi, T., Sakuta, T., & Yamaguchi, T. (1998). Intra-articular injection of collagenase induces experimental osteoarthritis in mature rabbits. Osteoarthritis Cartilage, 6(3), 177–186.

Article  CAS  PubMed  Google Scholar 

Kraus, V. B., Huebner, J. L., DeGroot, J., & Bendele, A. (2010). The OARSI histopathology initiative - Recommendations for histological assessments of osteoarthritis in the guinea pig. Osteoarthritis Cartilage, 18(Suppl 3), S35–S52.

Article  PubMed  PubMed Central  Google Scholar 

Jimenez, P. A., Glasson, S. S., Trubetskoy, O. V., & Haimes, H. B. (1997). Spontaneous osteoarthritis in Dunkin Hartley guinea pigs: Histologic, radiologic, and biochemical changes. Laboratory Animal Science, 47(6), 598–601.

CAS  PubMed  Google Scholar 

Asjid, R., Faisal, T., Qamar, K., Malik, S., Umbreen, F., & Fatima, M. (2019). Effect of platelet-rich plasma on Mankin scoring in chemically-induced animal model of osteoarthritis. Journal of College of Physicians Surgeons-Pakistan (JCPSP), 29(11), 1067–1071.

Article  Google Scholar 

Moussa, M., Lajeunesse, D., Hilal, G., El Atat, O., Haykal, G., Serhal, R., Chalhoub, A., Khalil, C., & Alaaeddine, N. (2017). Platelet rich plasma (PRP) induces chondroprotection via increasing autophagy, anti-inflammatory markers, and decreasing apoptosis in human osteoarthritic cartilage. Experimental Cell Research, 352(1), 146–156.

Article  CAS  PubMed  Google Scholar 

Wang, X. J., Wei, L., Xue, Y., & Li, R. S. (2021). Experimental observation of the sequence of tibial plateau chondrocyte and matrix degeneration in spontaneous osteoarthritis in Guinea pigs. BMC Musculoskeletal Disorders, 22, 395.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hwang, H. S., & Kim, H. A. (2015). Chondrocyte apoptosis in the pathogenesis of osteoarthritis. International Journal of Molecular Sciences, 16(11), 26035–26054.

Article  CAS  PubMed  PubMed Central  Google Scholar