Neuroactive steroids in the neuroendocrine control of food intake, metabolism, and reproduction

Y. Sze, P.J. Brunton, Neurosteroids and early-life programming: an updated perspective. Curr. Opin. Endocr. Metab. Res. 25, 100367 (2022)

Article  CAS  PubMed  PubMed Central  Google Scholar 

X. Liu, H. Shi, Regulation of estrogen receptor α expression in the hypothalamus by sex steroids: implication in the regulation of energy homeostasis. Int. J. Endocrinol. 2015, 1 (2015)

Google Scholar 

S. Giatti, S. Romano, M. Pesaresi, G. Cermenati, N. Mitro, D. Caruso, M.J. Tetel, L.M. Garcia-Segura, R.C. Melcangi, Neuroactive steroids and the peripheral nervous system: an update. Steroids 103, 23 (2015)

Article  CAS  PubMed  PubMed Central  Google Scholar 

S.H. Mellon, L.D. Griffin, Neurosteroids: biochemistry and clinical significance. Trends Endocrinol. Metab. 13, 35–43 (2002)

Article  CAS  PubMed  Google Scholar 

J. Luo, D. Liu, Does GPER really function as a g protein-coupled estrogen receptor in vivo? Front. Endocrinol. 11, 148 (2020)

Article  Google Scholar 

J. Zhu, Y. Zhou, B. Jin, J. Shu, Role of estrogen in the regulation of central and peripheral energy homeostasis: from a menopausal perspective. Ther. Adv. Endocrinol. Metab. 14, 20420188231199359 (2023)

Article  PubMed  PubMed Central  Google Scholar 

S.L. González, M.F. Coronel, M.C. Raggio, F. Labombarda, Progesterone receptor-mediated actions and the treatment of central nervous system disorders: an up-date of the known and the challenge of the unknown. Steroids 153, 108525 (2020)

Article  PubMed  Google Scholar 

P. Thomas, Membrane progesterone receptors (mPRs, PAQRs): review of structural and signaling characteristics. Cells 11, 1785 (2022)

Article  CAS  PubMed  PubMed Central  Google Scholar 

D.S. Reddy, Neurosteroids. in Prog. Brain Res. (Elsevier, 2010), pp. 113–137.

S.H. Luquet, H. Vaudry, R. Granata, Neuroendocrine control of feeding behavior. Front. Endocrinol. 10, 399 (2019)

Article  Google Scholar 

N. Geary, L. Asarian, K.S. Korach, D.W. Pfaff, S. Ogawa, Deficits in E2-dependent control of feeding, weight gain, and cholecystokinin satiation in ER-α null mice. Endocrinology 142, 4751 (2001)

Article  CAS  PubMed  Google Scholar 

G.C. Parker, M.E. McKee, C. Bishop, D.V. Coscina, Whole-body metabolism varies across the estrous cycle in Sprague–Dawley rats. Physiol. Behav. 74, 399 (2001)

Article  CAS  PubMed  Google Scholar 

N.H. Rogers, J.W. Perfield, K.J. Strissel, M.S. Obin, A.S. Greenberg, Reduced energy expenditure and increased inflammation are early events in the development of ovariectomy-induced obesity. Endocrinology 150, 2161 (2009)

Article  CAS  PubMed  PubMed Central  Google Scholar 

M.E.E. Jones, A.W. Thorburn, K.L. Britt, K.N. Hewitt, N.G. Wreford, J. Proietto, O.K. Oz, B.J. Leury, K.M. Robertson, S. Yao, E.R. Simpson, Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity. Proc. Natl Acad. Sci. USA. 97, 12735 (2000)

Article  CAS  PubMed  PubMed Central  Google Scholar 

P.A. Heine, J.A. Taylor, G.A. Iwamoto, D.B. Lubahn, P.S. Cooke, Increased adipose tissue in male and female estrogen receptor-α knockout mice. Proc. Natl Acad. Sci. 97, 12729 (2000)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Y. Xu, T.P. Nedungadi, L. Zhu, N. Sobhani, B.G. Irani, K.E. Davis, X. Zhang, F. Zou, L.M. Gent, L.D. Hahner, S.A. Khan, C.F. Elias, J.K. Elmquist, D.J. Clegg, Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction. Cell Metab. 14, 453 (2011)

Article  CAS  PubMed  PubMed Central  Google Scholar 

S. Musatov, W. Chen, D.W. Pfaff, M.G. Kaplitt, S. Ogawa, RNAi-mediated silencing of estrogen receptor α in the ventromedial nucleus of hypothalamus abolishes female sexual behaviors. Proc. Natl Acad. Sci. 103, 10456 (2006)

Article  CAS  PubMed  PubMed Central  Google Scholar 

K. Sano, M.C. Tsuda, S. Musatov, T. Sakamoto, S. Ogawa, Differential effects of site‐specific knockdown of estrogen receptor α in the medial amygdala, medial preoptic area, and ventromedial nucleus of the hypothalamus on sexual and aggressive behavior of male mice. Eur. J. Neurosci. 37, 1308 (2013)

Article  PubMed  Google Scholar 

T. Khodai, S.M. Luckman, Ventromedial nucleus of the hypothalamus neurons under the magnifying glass. Endocrinology 162, bqab141 (2021)

Article  PubMed  PubMed Central  Google Scholar 

M. López, M. Tena-Sempere, Estrogens and the control of energy homeostasis: a brain perspective. Trends Endocrinol. Metab. 26, 411 (2015)

Article  PubMed  Google Scholar 

D. Atasoy, J.N. Betley, H.H. Su, S.M. Sternson, Deconstruction of a neural circuit for hunger. Nature 488, 172 (2012)

Article  CAS  PubMed  PubMed Central  Google Scholar 

P. Sweeney, L.E. Gimenez, C.C. Hernandez, R.D. Cone, Targeting the central melanocortin system for the treatment of metabolic disorders. Nat. Rev. Endocrinol. 19, 507 (2023)

Article  CAS  PubMed  Google Scholar 

F.S.J. De Souza, S. Nasif, R. López-Leal, D.H. Levi, M.J. Low, M. Rubinsten, The estrogen receptor α colocalizes with proopiomelanocortin in hypothalamic neurons and binds to a conserved motif present in the neuron-specific enhancer nPE2. Eur. J. Pharmacol. 660, 181 (2011)

Article  PubMed  PubMed Central  Google Scholar 

K. Saito, X. Cao, Y. He, Y. Xu, Progress in the molecular understanding of central regulation of body weight by estrogens: estrogenic regulation of body weight. Obesity 23, 919 (2015)

Article  PubMed  Google Scholar 

L.E. Olofsson, A.A. Pierce, A.W. Xu, Functional requirement of AgRP and NPY neurons in ovarian cycle-dependent regulation of food intake. Proc. Natl Acad. Sci. USA. 106, 15932 (2009)

Article  CAS  PubMed  PubMed Central  Google Scholar 

A. Gouveia, R. de Oliveira Beleza, SM. Steculorum, AgRP neuronal activity across feeding-related behaviours. Eur J Neurosci 54, 7458 (2021)

Article  CAS  PubMed  Google Scholar 

L. Dye, J.E. Blundell, Implications for weight regulation. Hum. Reprod. 12, 1142 (1997)

Article  CAS  PubMed  Google Scholar 

E. Holmberg, J. Sjöstedt, E. Malinina, M. Johansson, S. Turkmen, G. Ragagnin, A. Lundqvist, M. Löfgren, L. Jaukkuri, M. Bixo, T. Bäckström, Implications for weight regulation. Front. Neuroendocrinol. 48, 70 (2018)

Article  CAS  PubMed  Google Scholar 

E. Holmberg, M. Johansson, T. Bäckström, M. Löfgren, D. Haage, Repeated allopregnanolone exposure induces weight gain in schedule fed rats on high fat diet. Physiol. Behav. 140, 1 (2015)

Article  CAS  PubMed  Google Scholar 

A. Lundqvist, H. Sandström, T. Bäckström, The relationship between weight gain during pregnancy and allopregnanolone levels: a longitudinal study. Endocr. Connect. 6, 253 (2017)

Article  CAS  PubMed  PubMed Central  Google Scholar 

B. Meister, Neurotransmitters in key neurons of the hypothalamus that regulate feeding behavior and body weight. Physiol. Behav. 92, 263 (2007)

Article  CAS  PubMed  Google Scholar 

Q. Tong, C.-P. Ye, J.E. Jones, J.K. Elmquist, B.B. Lowell, Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nat. Neurosci. 11, 998 (2008)

Article  CAS  PubMed  PubMed Central  Google Scholar 

H. Hedström, T. Bäckström, M. Bixo, S. Nyberg, M. Wang, I. Gideonsson, S. Turkmen, Women with polycystic ovary syndrome have elevated serum concentrations of and altered GABAA receptor sensitivity to allopregnanolone. Clin. Endocrinol. (Oxf.) 83, 643 (2015)

Article  PubMed  Google Scholar 

S. Turkmen, L. Andreen, Y. Cengiz, Effects of Roux-en-Y gastric bypass surgery on eating behaviour and allopregnanolone levels in obese women with polycystic ovary syndrome. Gynecol. Endocrinol. 31, 301 (2015)

Article  CAS  PubMed  Google Scholar 

T.L. Stincic, J. Qiu, A.M. Connors, M.J. Kelly, O.K. Rønnekleiv, Arcuate and preoptic kisspeptin neurons exhibit differential projections to hypothalamic nuclei and exert opposite postsynaptic effects on hypothalamic paraventricular and dorsomedial nuclei in the female mouse. Eneuro 8, ENEURO.0093 (2021)

Article  CAS  PubMed  Google Scholar 

H. Stevenson, S. Bartram, M.M. Charalambides, S. Murthy, T. Petitt, A. Pradeep, O. Vineall, I. Abaraonye, A. Lancaster, K. Koysombat, B. Patel, A. Abbara, Kisspeptin-neuron control of LH pulsatility and ovulation. Front. Endocrinol. 13, 951938 (2022)

Article  Google Scholar 

M.A. Mittelman-Smith, H. Williams, S.J. Krajewski-Hall, J. Lai, P. Ciofi, N.T. McMullen, N.E. Rance, Arcuate kisspeptin/neurokinin B/dynorphin (KNDy) neurons mediate the estrogen suppression of gonadotropin secretion and body weight. Endocrinology 153, 2800 (2012)

Article  CAS  PubMed  PubMed Central 

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