Yolk sac tumor (YST) is a rare cancer that affects young people. Symptoms include visual problems, seizures, and paralysis. Treatment options include surgery, chemotherapy (CT), and radiation therapy (RT).

A man with seminoma and liver metastases had seizures and was found to have a lesion on the left frontal lobe. The tumor was removed through craniotomy surgery and identified as a pure-YST. Adjuvant RT and CT led to remission and the patient is symptom-free after two years.

Tumors were commonly found in the pineal region, cerebral lobes, and sellar region. Male and female patients had different overall survival but not among different tumor locations. There was no significant difference in overall survival between the two histological subtypes.

The study found that complete tumor resection along with radiation and chemotherapy is the best option for managing brain tumors. Females have a better prognosis. The patients were followed for an average of 28 months, with a median overall survival of 13 months.

Ethics committee approval was unnecessary, as this was a systematic literature review. Informed consent was administered and obtained from the patient and family members to publish sensitive material. In any case, any photos or documents attributable to the patient were anonymized.

None of the Authors received funding from any association for drafting this manuscript.

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria educational grants; participation in speakers' bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed

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