R.A. DeFronzo, From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes 58, 773–795 (2009)

Article  CAS  PubMed  PubMed Central  Google Scholar 

M.J. Davies, D.A. D’Alessio, J. Fradkin, W.N. Kernan, C. Mathieu, G. Mingrone, P. Rossing, A. Tsapas, D.J. Wexler, J.B. Buse, Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 41(12), 2669–2701 (2018)

Article  PubMed  PubMed Central  Google Scholar 

M. Peyrot, A.H. Barnett, L.F. Meneghini, P.M. Schumm-Draeger, Insulin adherence behaviours and barriers in the multinational Global Attitudes of Patients and Physicians in Insulin Therapy study. Diabet. Med. 29(5), 682–689 (2012)

Article  CAS  PubMed  PubMed Central  Google Scholar 

T. Suzuki, K. Takahashi, D. Fujiwara, M. Shii, S. Takekawa, T. Matsuoka, A reliable serum C-peptide index for the selection of an insulin regimen to achieve good glycemic control in obese patients with type 2 diabetes: an analysis from a short-term study with intensive insulin therapy. Diabetol. Int 7(3), 235–243 (2015)

Article  PubMed  PubMed Central  Google Scholar 

D. Fujiwara, K. Takahashi, T. Suzuki, M. Shii, Y. Nakashima, S. Takekawa, A. Yoshida, T. Matsuoka, Postprandial serum C-peptide value is the optimal index to identify patients with non-obese type 2 diabetes who require multiple daily insulin injection: Analysis of C-peptide values before and after short-term intensive insulin therapy. J. Diabetes Investig. 4(6), 618–625 (2013)

Article  CAS  PubMed  PubMed Central  Google Scholar 

American Diabetes Association, Standards of Medical Care in Diabetes, Pharmacologic Approaches to Glycemic Treatment. Diabetes Care 40(Supplement_1), S64–S74 (2017)

Article  Google Scholar 

A.E. Butler, J. Janson, S. Bonner-Weir, R. Ritzel, R.A. Rizza, P.C. Butler, Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52(1), 102–110 (2003)

Article  CAS  PubMed  Google Scholar 

H. Sakuraba, H. Mizukami, N. Yagihashi, R. Wada, C. Hanyu, S. Yagihashi, Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients. Diabetologia 45(1), 85–96 (2002)

Article  CAS  PubMed  Google Scholar 

J.S. Skyler, G.L. Bakris, E. Bonifacio, T. Darsow, R.H. Eckel, L. Groop, P.H. Groop, Y. Handelsman, R.A. Insel, C. Mathieu, A.T. McElvaine, J.P. Palmer, A. Pugliese, D.A. Schatz, J.M. Sosenko, J.P. Wilding, R.E. Ratner, Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis. Diabetes 66(2), 241–255 (2017)

Article  CAS  PubMed  Google Scholar 

G. Reach, V. Pechtner, R. Gentilella, A. Corcos, A. Ceriello, Clinical inertia and its impact on treatment intensification in people with type 2 diabetes mellitus. Diabetes Metab. 43(6), 501–511 (2017)

Article  CAS  PubMed  Google Scholar 

K. Khunti, A. Nikolajsen, B.L. Thorsted, M. Andersen, M.J. Davies, S.K. Paul, Clinical inertia with regard to intensifying therapy in people with type 2 diabetes treated with basal insulin. Diabetes Obes. Metab. 18(4), 401–409 (2016)

Article  CAS  PubMed  PubMed Central  Google Scholar 

K.J. Lipska, J.S. Ross, Y. Miao, N.D. Shah, S.J. Lee, Stein- man MA. Potential overtreatment of diabetes mel- litus in older adults with tight glycemic control. JAMA Intern Med 175(3), 356–362 (2015)

Article  PubMed  PubMed Central  Google Scholar 

C.L. Tseng, O. Soroka, M. Maney, D.C. Aron, L.M. Pogach, Assessing potential glycemic overtreatment in persons at hypoglycemic risk. JAMA Intern Med 174(2), 259–268 (2014)

Article  PubMed  Google Scholar 

American Diabetes Association, 9. Pharmacologic approaches to glycemic treatment: standards of medical care in diabetes-2019. Diabetes Care 42(Suppl. 1), S90–S102 (2019)

Article  Google Scholar 

P. Aschner, Insulin Therapy in Type 2 Diabetes. Am J Ther. 27(1), e79–e90 (2020).

Article  PubMed  Google Scholar 

D. Giugliano, J. Sieradzki, A. Stefanski, R. Gentilella, Personalized intensification of insulin therapy in type 2 diabetes - does a basal-bolus regimen suit all patients? Curr. Med Res Opin. 32(8), 1425–1434 (2016)

Article  CAS  PubMed  Google Scholar 

K.K. Ray, D.M. Kendall, Z. Zhao, X. Peng, A.E. Caballero, W.H. Polonsky, B.L. Nordstrom, L. Fan, B.H. Curtis, M.J. Davies, A multinational observational study assessing insulin use: Understanding the determinants associated with progression of therapy. Diabetes Obes. Metab. 21(5), 1101–1110 (2019)

Article  CAS  PubMed  PubMed Central  Google Scholar 

A. Al Mansari, Y. Obeid, N. Islam, M. Fariduddin, A. Hassoun, K. Djaballah, M. Malek, D. Dicker, T. Chaudhury, GOAL study: clinical and non-clinical predictive factors for achieving glycemic control in people with type 2 diabetes in real clinical practice. BMJ. Open Diabetes Res. Care 6(1), e000519 (2018)

Article  PubMed  PubMed Central  Google Scholar 

A.G. Jones, A.T. Hattersley, The clinical utility of C-peptide measurement in the care of patients with diabetes. Diabet. Med. 30, 803–817 (2013)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Y. Saisho, Postprandial C-Peptide to Glucose Ratio as a Marker of β Cell Function: Implication for the Management of Type 2 Diabetes. Int J. Mol. Sci. 17(5), pii: E744 (2016)

Article  Google Scholar 

J.D. Lin, Levels of the first-phase insulin secretion deficiency as a predictor for type 2 diabetes onset by using clinical-metabolic models. Ann. Saudi Med. 35, 138–145 (2015)

Article  CAS  PubMed  PubMed Central  Google Scholar 

A. Goto, M. Takaichi, M. Kishimoto, Y. Takahashi, H. Kajio, T. Shimbo et al. Body mass index, fasting plasma glucose levels, and C-peptide levels as predictors of the future insulin use in Japanese type 2 diabetic patients. Endocr. J. 57, 237–244 (2010)

Article  CAS  PubMed  Google Scholar 

P.W. Mu, D.Z. Liu, Y. Lin, D. Liu, F. Zhang, Y.J. Zhang, S. Lin, L.Q. Wang, M.M. Wang, J. Shu, L.Y. Zeng, Y.M. Chen, The Postprandial-to-Fasting Serum C-Peptide Ratio is a Predictor of Response to Basal Insulin-Supported Oral Antidiabetic Drug(s) Therapy: A Retrospective Analysis. Diabetes Ther. 9(3), 963–971 (2018)

Article  CAS  PubMed  PubMed Central  Google Scholar