García-Ortiz A, Rodríguez-García Y, Encinas J, Maroto-Martín E, Castellano E, Teixidó J et al (2021) The role of tumor microenvironment in multiple myeloma development and progression. Cancers 13(2):217

Article  PubMed  PubMed Central  Google Scholar 

Podar K, Tai Y-T, Lin BK, Narsimhan RP, Sattler M, Kijima T et al (2002) Vascular endothelial growth factor-induced migration of multiple myeloma cells is associated with β1 integrin- and phosphatidylinositol 3-kinase-dependent PKCα Activation*. J Biol Chem 277(10):7875–7881

Article  CAS  PubMed  Google Scholar 

Hussain A, Almenfi HF, Almehdewi AM, Hamza MS, Bhat MS, Vijayashankar NP (2019) Laboratory features of newly diagnosed multiple myeloma patients. Cureus. 11(5):e4716

PubMed  PubMed Central  Google Scholar 

Allmeroth K, Horn M, Kroef V, Miethe S, Müller R-U, Denzel MS (2021) Bortezomib resistance mutations in PSMB5 determine response to second-generation proteasome inhibitors in multiple myeloma. Leukemia 35(3):887–892

Article  CAS  PubMed  Google Scholar 

Podar K, Gouill SL, Zhang J, Opferman JT, Zorn E, Tai YT et al (2008) A pivotal role for Mcl-1 in Bortezomib-induced apoptosis. Oncogene 27(6):721–731

Article  CAS  PubMed  Google Scholar 

Pinto V, Bergantim R, Caires HR, Seca H, Guimarães JE, Vasconcelos MH (2020) Multiple myeloma: available therapies and causes of drug resistance. Cancers 12(2):407

Article  CAS  PubMed  PubMed Central  Google Scholar 

Besse L, Besse A, Mendez-Lopez M, Vasickova K, Sedlackova M, Vanhara P et al (2019) A metabolic switch in proteasome inhibitor-resistant multiple myeloma ensures higher mitochondrial metabolism, protein folding and sphingomyelin synthesis. Haematologica 104(9):e415–e419

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shi W, Chen Z, Li L, Liu H, Zhang R, Cheng Q et al (2019) Unravel the molecular mechanism of XBP1 in regulating the biology of cancer cells. J Cancer 10(9):2035–2046

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chalmers F, Mogre S, Son J, Blazanin N, Glick AB (2019) The multiple roles of the unfolded protein response regulator IRE1α in cancer. Mol Carcinog 58(9):1623–1630

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nikesitch N, Lee JM, Ling S, Roberts TL (2018) Endoplasmic reticulum stress in the development of multiple myeloma and drug resistance. Clin Translat Immunol 7(1):e1007

Article  Google Scholar 

Shirazi F, Jones RJ, Singh RK, Zou J, Kuiatse I, Berkova Z et al (2020) Activating KRAS, NRAS, and BRAF mutants enhance proteasome capacity and reduce endoplasmic reticulum stress in multiple myeloma. Proc Natl Acad Sci 117(33):20004–20014

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park S-M, Kang T-I, So J-S (2021) Roles of XBP1s in transcriptional regulation of target genes. Biomedicines 9(7):791

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gonnella R, Gilardini Montani MS, Guttieri L, Romeo MA, Santarelli R, Cirone M (2021) IRE1 Alpha/XBP1 axis sustains primary effusion lymphoma cell survival by promoting cytokine release and STAT3 activation. Biomedicines 9(2):118

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K (2001) XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107(7):881–891

Article  CAS  PubMed  Google Scholar 

Mo Y, Liu B, Qiu S, Wang X, Zhong L, Han X et al (2020) Down-regulation of microRNA-34c-5p alleviates neuropathic pain via the SIRT1/STAT3 signaling pathway in rat models of chronic constriction injury of sciatic nerve. J Neurochem 154(3):301–315

Article  CAS  PubMed  Google Scholar 

Bartoszewska S, Cabaj A, Dąbrowski M, Collawn JF, Bartoszewski R (2019) miR-34c-5p modulates X-box-binding protein 1 (XBP1) expression during the adaptive phase of the unfolded protein response. FASEB J 33(10):11541–11554

Article  CAS  PubMed  PubMed Central  Google Scholar 

Byrd AE, Aragon IV, Brewer JW (2012) MicroRNA-30c-2* limits expression of proadaptive factor XBP1 in the unfolded protein response. J Cell Biol 196(6):689–698

Article  CAS  PubMed  PubMed Central  Google Scholar 

Duan Q, Wang X, Gong W, Ni L, Chen C, He X et al (2012) ER stress negatively modulates the expression of the miR-199a/214 cluster to regulates tumor survival and progression in human hepatocellular cancer. PLoS ONE 7(2):e31518

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu X, Yan H, Zhang L, Liu J, Huang Y, Cheng H (2020) Up-regulation of miR-34c-5p inhibits nasopharyngeal carcinoma cells by mediating NOTCH1. Biosci Rep. 40(6):BSR20200302

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jacques C, Tesfaye R, Lavaud M, Georges S, Baudhuin M, Lamoureux F et al (2020) Implication of the p53-related miR-34c, -125b, and -203 in the osteoblastic differentiation and the malignant transformation of bone sarcomas. Cells 9(4):810

Article  CAS  PubMed  PubMed Central  Google Scholar 

Louis KS, Siegel AC (2011) Cell viability analysis using trypan blue: manual and automated methods. Springer, Mammalian cell viability, pp 7–12

Google Scholar 

Gandolfi S, Laubach JP, Hideshima T, Chauhan D, Anderson KC, Richardson PG (2017) The proteasome and proteasome inhibitors in multiple myeloma. Cancer Metastasis Rev 36(4):561–584

Article  CAS  PubMed  Google Scholar 

Borjan B, Kern J, Steiner N, Gunsilius E, Wolf D, Untergasser G (2020) Spliced XBP1 levels determine sensitivity of multiple myeloma cells to proteasome inhibitor bortezomib independent of the unfolded protein response mediator GRP78. Front Oncol. 9:1530

Article  PubMed  PubMed Central  Google Scholar 

Cagle P, Niture S, Srivastava A, Ramalinga M, Aqeel R, Rios-Colon L et al (2019) MicroRNA-214 targets PTK6 to inhibit tumorigenic potential and increase drug sensitivity of prostate cancer cells. Sci Rep 9(1):1–13

Article  CAS  Google Scholar 

Han W, Cui H, Liang J, Su X (2020) Role of MicroRNA-30c in cancer progression. J Cancer 11(9):2593–2601

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ostadrahimi S, Fayaz S, Parvizhamidi M, Abedi-Valugerdi M, Hassan M, Kadivar M et al (2018) Downregulation of miR-1266-5P, miR-185-5P and miR-30c-2 in prostatic cancer tissue and cell lines. Oncol Lett 15(5):8157–8164

PubMed  PubMed Central  Google Scholar 

Duan Q, Chen C, Yang L, Li N, Gong W, Li S et al (2015) MicroRNA regulation of unfolded protein response transcription factor XBP1 in the progression of cardiac hypertrophy and heart failure in vivo. J Transl Med 13(1):1–11

Article  Google Scholar 

Yuan X, Ma R, Yang S, Jiang L, Wang Z, Zhu Z, Li H (2019) miR-520g and miR-520h overcome bortezomib resistance in multiple myeloma via suppressing APE1. Cell Cycle 18(14):1660–1669

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tu Y, Hu Y (2021) MiRNA-34c-5p protects against cerebral ischemia/reperfusion injury: involvement of anti-apoptotic and anti-inflammatory activities. Metab Brain Dis 36(6):1341–1351

Article  CAS  PubMed  Google Scholar 

Letai AG (2008) Diagnosing and exploiting cancer’s addiction to blocks in apoptosis. Nat Rev Cancer 8(2):121–132

Article  CAS  PubMed  Google Scholar 

Touzeau C, Maciag P, Amiot M, Moreau P (2018) Targeting Bcl-2 for the treatment of multiple myeloma. Leukemia 32(9):1899–1907

Article  CAS  PubMed  Google Scholar 

Amodio N, Di Martino MT, Foresta U, Leone E, Lionetti M, Leotta M, Gullà AM, Pitari MR, Conforti F, Rossi MJ, Agosti V (2012) miR-29b sensitizes multiple myeloma cells to bortezomib-induced apoptosis through the activation of a feedback loop with the transcription factor Sp1. Cell Death Dis 3(11):e436-439

Article  CAS  PubMed  PubMed Central  Google Scholar