Bloodstream infections (BSIs) represent a critical public health concern, primarily due to their rapid progression and severe implications such as sepsis and septic shock. This study introduces an innovative Explanable Artificial Intelligence (XAI) framework, leveraging historical electronic health records (EHRs) to enhance BSI prediction. Unlike traditional models that rely heavily on real-time clinical data, our XAI-based approach utilizes a comprehensive dataset incorporating demographic data, laboratory results, and full medical histories from St. Olavs Hospital, Trondheim, Norway, covering 35,591 patients between 2015 and 2020. We developed models to differentiate between high-risk and low-risk BSI cases effectively, optimizing healthcare resource allocation and potentially reducing healthcare costs. Our results demonstrate superior predictive accuracy, particularly the tree-based models, which significantly outperformed contemporary models in both specificity and sensitivity metrics.

The authors have declared no competing interest.

Yes

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The details of the IRB/oversight body that provided approval or exemption for the research described are given below:

The use of the EHRs data in this project has been approved by the Regional Commitees for Medical and Health Research Ethics (REK) in Central Norway by REK no. 2020/26184.

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