High estradiol levels in fresh embryo transfer cycles are not associated with detrimental impact on birth outcomes

Ahart E, Luevano G, Marsh C. To freeze or not to freeze, what is the answer? Fertil Steril. 2023;119(2):195. https://doi.org/10.1016/j.fertnstert.2022.12.020.

Article  PubMed  Google Scholar 

Eapen A, Sparks A. Improved outcomes following frozen embryo transfer does not provide a “universal license to chill.” Fertil Steril. 2018;110(5):847–8. https://doi.org/10.1016/j.fertnstert.2018.06.033.

Article  PubMed  Google Scholar 

Chen Z-J, Legro RS. Fresh versus frozen embryos in polycystic ovary syndrome. N Engl J Med. 2016;375(20): e42. https://doi.org/10.1056/NEJMc1611871.

Article  PubMed  Google Scholar 

Wang A, Santistevan A, Hunter Cohn K, et al. Freeze-only versus fresh embryo transfer in a multicenter matched cohort study: contribution of progesterone and maternal age to success rates. Fertil Steril. 2017;108(2):254-261.e4. https://doi.org/10.1016/j.fertnstert.2017.05.007.

Article  CAS  PubMed  Google Scholar 

Acharya KS, Acharya CR, Bishop K, Harris B, Raburn D, Muasher SJ. Freezing of all embryos in in vitro fertilization is beneficial in high responders, but not intermediate and low responders: an analysis of 82,935 cycles from the Society for Assisted Reproductive Technology registry. Fertil Steril. 2018;110(5):880–7. https://doi.org/10.1016/j.fertnstert.2018.05.024.

Article  PubMed  Google Scholar 

Karatasiou GI, Bosdou JK, Venetis CA, et al. Is the probability of pregnancy after ovarian stimulation for IVF associated with serum estradiol levels on the day of triggering final oocyte maturation with hCG? A systematic review and meta-analysis. J Assist Reprod Genet. 2020;37(7):1531–41. https://doi.org/10.1007/s10815-020-01829-z.

Article  PubMed  PubMed Central  Google Scholar 

Chenette PE, Sauer MV, Paulson RJ. Very high serum estradiol levels are not detrimental to clinical outcome of in vitro fertilization. Fertil Steril. 1990;54(5):858–63. https://doi.org/10.1016/s0015-0282(16)53946-6.

Article  CAS  PubMed  Google Scholar 

Imudia AN, Goldman RH, Awonuga AO, Wright DL, Styer AK, Toth TL. The impact of supraphysiologic serum estradiol levels on peri-implantation embryo development and early pregnancy outcome following in vitro fertilization cycles. J Assist Reprod Genet. 2014;31(1):65–71. https://doi.org/10.1007/s10815-013-0117-8.

Article  PubMed  Google Scholar 

Joo BS, Park SH, An BM, Kim KS, Moon SE, Moon HS. Serum estradiol levels during controlled ovarian hyperstimulation influence the pregnancy outcome of in vitro fertilization in a concentration-dependent manner. Fertil Steril. 2010;93(2):442–6. https://doi.org/10.1016/j.fertnstert.2009.02.066.

Article  CAS  PubMed  Google Scholar 

Mitwally MF, Bhakoo HS, Crickard K, Sullivan MW, Batt RE, Yeh J. Estradiol production during controlled ovarian hyperstimulation correlates with treatment outcome in women undergoing in vitro fertilization-embryo transfer. Fertil Steril. 2006;86(3):588–96. https://doi.org/10.1016/j.fertnstert.2006.02.086.

Article  CAS  PubMed  Google Scholar 

Pelkonen S, Koivunen R, Gissler M, et al. Perinatal outcome of children born after frozen and fresh embryo transfer: the Finnish cohort study 1995–2006. Hum Reprod. 2010;25(4):914–23. https://doi.org/10.1093/humrep/dep477.

Article  CAS  PubMed  Google Scholar 

Sha T, Yin X, Cheng W, Massey IY. Pregnancy-related complications and perinatal outcomes resulting from transfer of cryopreserved versus fresh embryos in vitro fertilization: a meta-analysis. Fertil Steril. 2018;109(2):330-342.e9. https://doi.org/10.1016/j.fertnstert.2017.10.019.

Article  PubMed  Google Scholar 

Imudia AN, Awonuga AO, Doyle JO, et al. Peak serum estradiol level during controlled ovarian hyperstimulation is associated with increased risk of small for gestational age and preeclampsia in singleton pregnancies after in vitro fertilization. Fertil Steril. 2012;97(6):1374–9. https://doi.org/10.1016/j.fertnstert.2012.03.028.

Article  CAS  PubMed  Google Scholar 

Pereira N, Elias RT, Christos PJ, et al. Supraphysiologic estradiol is an independent predictor of low birth weight in full-term singletons born after fresh embryo transfer. Hum Reprod. 2017;32(7):1410–7. https://doi.org/10.1093/humrep/dex095.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pereira N, Reichman DE, Goldschlag DE, Lekovich JP, Rosenwaks Z. Impact of elevated peak serum estradiol levels during controlled ovarian hyperstimulation on the birth weight of term singletons from fresh IVF-ET cycles. J Assist Reprod Genet. 2015;32(4):527–32. https://doi.org/10.1007/s10815-015-0434-1.

Article  PubMed  PubMed Central  Google Scholar 

Sunkara SK, La Marca A, Seed PT, Khalaf Y. Increased risk of preterm birth and low birthweight with very high number of oocytes following IVF: an analysis of 65 868 singleton live birth outcomes. Hum Reprod. 2015;30(6):1473–80. https://doi.org/10.1093/humrep/dev076.

Article  CAS  PubMed  Google Scholar 

Bourdon M, Ouazana M, Maignien C, et al. Impact of supraphysiological estradiol serum levels on birth weight in singletons born after fresh embryo transfer. Reprod Sci. 2020;27(9):1770–7. https://doi.org/10.1007/s43032-020-00174-x.

Article  CAS  PubMed  Google Scholar 

Royster GDI, Hill MJ, Zarek SM, et al. J. Three day progesterone area under the curve: a better test than progesterone on the day of hCG? Fertil Steril. 2014;102(3):85–6. https://doi.org/10.1016/j.fertnstert.2014.07.290.

Article  Google Scholar 

Heitmann RJ, Hill MJ, Richter KS, DeCherney AH, Widra EA. The simplified SART embryo scoring system is highly correlated to implantation and live birth in single blastocyst transfers. J Assist Reprod Genet. 2013;30(4):563–7. https://doi.org/10.1007/s10815-013-9932-1.

Article  PubMed  PubMed Central  Google Scholar 

Harrison W, Goodman D. Epidemiologic trends in neonatal intensive care, 2007-2012 [published correction appears in JAMA Pediatr. 2015 Sep;169(9):878]. JAMA Pediatr. 2015;169(9):855–62. https://doi.org/10.1001/jamapediatrics.2015.1305.

Article  PubMed  Google Scholar 

Li M, Kort J, Baker VL. Embryo biopsy and perinatal outcomes of singleton pregnancies: an analysis of 16,246 frozen embryo transfer cycles reported in the Society for Assisted Reproductive Technology Clinical Outcomes Reporting System. Am J Obstet Gynecol. 2021;224(5):500.e1-500.e18. https://doi.org/10.1016/j.ajog.2020.10.043.

Article  CAS  PubMed  Google Scholar 

Al-Azemi M, Kyrou D, Kolibianakis EM, et al. Elevated progesterone during ovarian stimulation for IVF. Reprod Biomed Online. 2012;24(4):381–8. https://doi.org/10.1016/j.rbmo.2012.01.010.

Article  CAS  PubMed  Google Scholar 

Healy MW, Patounakis G, Connell MT, et al. Does a frozen embryo transfer ameliorate the effect of elevated progesterone seen in fresh transfer cycles? Fertil Steril. 2016;105(1):93-9.e1. https://doi.org/10.1016/j.fertnstert.2015.09.015.

Article  CAS  PubMed  Google Scholar 

Kyrou D, Popovic-Todorovic B, Fatemi HM, et al. Does the estradiol level on the day of human chorionic gonadotrophin administration have an impact on pregnancy rates in patients treated with rec-FSH/GnRH antagonist? Hum Reprod. 2009;24(11):2902–9. https://doi.org/10.1093/humrep/dep290.

Article  CAS  PubMed  Google Scholar 

Ullah K, Rahman TU, Pan HT, et al. Serum estradiol levels in controlled ovarian stimulation directly affect the endometrium. J Mol Endocrinol. 2017;59(2):105–19. https://doi.org/10.1530/JME-17-0036.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Valbuena D, Martin J, de Pablo JL, Remohí J, Pellicer A, Simón C. Increasing levels of estradiol are deleterious to embryonic implantation because they directly affect the embryo. Fertil Steril. 2001;76(5):962–8. https://doi.org/10.1016/s0015-0282(01)02018-0.

Article  CAS  PubMed  Google Scholar 

Dunne C, Cho K, Shan A, et al. Peak serum estradiol level during controlled ovarian stimulation is not associated with lower levels of pregnancy-associated plasma protein-A or small for gestational age infants: a cohort study. J Obstet Gynaecol Can. 2017;39(10):870–9. https://doi.org/10.1016/j.jogc.2017.01.031.

Article  PubMed  Google Scholar 

Zavy MT, Craig LB, Wild RA, Kahn SN, O’Leary D, Hansen KR. In high responding patients undergoing an initial IVF cycle, elevated estradiol on the day of hCG has no effect on live birth rate. Reprod Biol Endocrinol. 2014;12:119. https://doi.org/10.1186/1477-7827-12-119. Published 2014 Nov 28.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang M, Jin L, Shi J, et al. Estradiol on trigger day: irrelevant to live birth rates of fresh cycles but positively associated with cumulative live birth rates. Int J Gynaecol Obstet. 2023;163(2):627–38. https://doi.org/10.1002/ijgo.14887.

Article  PubMed  Google Scholar 

Yan J, Qin Y, Zhao H, et al. Live birth with or without preimplantation genetic testing for aneuploidy. N Engl J Med. 2021;385(22):2047–58. https://doi.org/10.1056/NEJMoa2103613.

Article  CAS  PubMed  Google Scholar 

Roeca C, Johnson RL, Truong T, Carlson NE, Polotsky AJ. Birth outcomes are superior after transfer of fresh versus frozen embryos for donor oocyte recipients. Hum Reprod. 2020;35(12):2850–9. https://doi.org/10.1093/humrep/deaa245.

Article  PubMed  Google Scholar 

Eaton JL, Truong T, Li YJ, Polotsky AJ. Prevalence of a good perinatal outcome with cryopreserved compared with fresh donor oocytes. Obstet Gynecol. 2020;135(3):709–16. https://doi.org/10.1097/AOG.0000000000003695.

Article  PubMed  PubMed Central  Google Scholar 

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