Available online 11 April 2024, 101377

Greater activity in the VS during reward anticipation predicted binge eating onset.

Greater left VS and left OFC activity during reward receipt predicted binge eating onset.

Individual differences in reward processing may contribute to the development of binge eating.

Binge eating is characterized as eating a large amount of food and feeling a loss of control while eating. However, the neurobiological mechanisms associated with the onset and maintenance of binge eating are largely unknown. Recent neuroimaging work has suggested that increased responsivity within reward regions of the brain to the anticipation or receipt of rewards is related to binge eating; however, limited longitudinal data has precluded understanding of the role of reward responsivity in the development of binge eating. The current study used data from the Adolescent Brain and Cognitive Development® (ABCD) longitudinal study dataset to assess whether heightened neural responses to different phases of reward processing (reward anticipation and receipt) (1) differentiated individuals with binge eating from matched controls, and (2) predicted the onset of binge eating in an "at risk" sample. Consistent with hypotheses, heightened neural responsivity in the right caudate and bilateral VS during reward anticipation differentiated youth with and without binge eating. Moreover, greater VS response to reward anticipation predicted binge eating two years later. Neural responses to reward receipt also were consistent with hypotheses, such that heightened VS and OFC responses differentiated youth with and without binge eating and predicted the presence of binge eating two years later. Findings from the current study suggest that hypersensitivity to rewards may contribute to the development of binge eating during early adolescence.

Adolescents

Binge Eating

ABCD Study

Reward

Disordered Eating

© 2024 Published by Elsevier Ltd.