Cerasa A, Gaggioli A, Marino F, Riva G, Pioggia G. The promise of the metaverse in mental health: the new era of MEDverse. Heliyon. 2022. https://doi.org/10.1016/j.heliyon.2022.e11762.

Article  PubMed  PubMed Central  Google Scholar 

• Riva G, Wiederhold BK, Villani D. Toward a humane metaverse: challenges and opportunities. Cyberpsychol Behav Soc Netw. 2024;27(1):3–8. The article covers the changes in the “we-mode” triggered by the move from physical to digital communities, as well as examines the neural foundations of the "we-mode" using contemporary neuroscience research. With the term “we-mode”, the authors refer to neurocognitive processes underlying the synchronization of different neurophysiological parameters, including heart rate and neural oscillations, occurring in social interactions.

Article  PubMed  Google Scholar 

Cheng R, Wu N, Varvello M, Chen S, Han B. Are we ready for metaverse? A measurement study of social virtual reality platforms. In Proceedings of the 22nd ACM Internet Measurement Conference (IMC ’22), October 25–27, Nice, France. ACM, New York, NY, USA, 2022:15 https://doi.org/10.1145/3517745.3561417.

Stylianos M. Metaverse. Encyclopedia. 2022;2(1):486–97.

Article  Google Scholar 

Song YT, Qin J. Metaverse and personal healthcare. Procedia Comput Sci. 2022;210:189–97.

Article  Google Scholar 

Plechatá A, Makransky G, Böhm R. Can extended reality in the metaverse revolutionise health communication? npj Digit Med. 2022;5:132. https://doi.org/10.1038/s41746-022-00682-x.

Article  PubMed  PubMed Central  Google Scholar 

Ali S, Abdullah, Armand TPT, Athar A, Hussain A, Ali M, Yaseen M, Joo MI, Kim HC. Metaverse in healthcare integrated with explainable ai and blockchain: enabling immersiveness, ensuring trust, and providing patient data security. Sensors. 2023;23(2):565.

Article  PubMed  PubMed Central  Google Scholar 

Flavián C, Ibáñez-Sánchez S, Orús C, Barta S. The dark side of the metaverse: the role of gamification in event virtualization. Int J Inf Manage. 2024;75(2024): 102726. https://doi.org/10.1016/j.ijinfomgt.2023.102726.

Article  Google Scholar 

Riva G, Wiederhold BK, Mantovani F. Searching for the metaverse: neuroscience of physical and digital communities. Cyberpsychol Behav Soc Netw. 2024;27(1):9–18.

Article  PubMed  PubMed Central  Google Scholar 

Friston KJ. Does predictive coding have a future? Nat Neurosci. 2018;21(8):1019–21.

Article  CAS  PubMed  Google Scholar 

Apps MA, Tsakiris M. The free-energy self: a predictive coding account of self-recognition. Neurosci Biobehav Rev. 2014;41:85–97.

Article  PubMed  Google Scholar 

Smith R, Badcock P, Friston KJ. Recent advances in the application of predictive coding and active inference models within clinical neuroscience. Psychiatry Clin Neurosci. 2021;75(1):3–13.

Article  PubMed  Google Scholar 

Sterzer P, Adams RA, Fletcher P, Frith C, Lawrie SM, Muckli L, Petrovic P, Uhlhaas P, Voss M, Corlett PR. The predictive coding account of psychosis. Biol Psychiat. 2018;84(9):634–43.

Article  PubMed  Google Scholar 

Riva G, Serino S, Di Lernia D, Pagnini F. Regenerative virtual therapy: the use of multisensory technologies and mindful attention for updating the altered representations of the bodily self. Front Syst Neurosci. 2021;15: 749268.

Article  PubMed  PubMed Central  Google Scholar 

Riva G, Di Lernia D, Sajno E, Sansoni M, Bartolotta S, Serino S, Gaggioli A, Wiederhold BK. Virtual reality therapy in the metaverse: merging VR for the outside with VR for the inside. Annu Rev Cyberther Telemed. 2021;19:3–8.

Google Scholar 

Bell IH, Nicholas J, Alvarez-Jimenez M, Thompson A, Valmaggia L. Virtual reality as a clinical tool in mental health research and practice. Dialogues Clin Neurosci. 2020;22(2):169–77. https://doi.org/10.31887/DCNS.2020.22.2/lvalmaggia.

Article  PubMed  PubMed Central  Google Scholar 

Ford TJ, Buchanan DM, Azeez A, Benrimoh DA, Kaloiani I, Bandeira ID, Hunegnaw S, Lan L, Gholmieh M, Buch V, Williams NR. Taking modern psychiatry into the metaverse: integrating augmented, virtual, and mixed reality technologies into psychiatric care. Front digit health. 2023;5:1146806. https://doi.org/10.3389/fdgth.2023.1146806.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wenlin L, Anupreet S, Amanda MB, Thomas V. Social network theory. University of Southern California. 2017. https://doi.org/10.1002/9781118783764.wbieme0092.

Article  Google Scholar 

Haslam SA, Jetten J, Postmes T, Haslam C. Social identity, health and well-being: an emerging agenda for applied psychology. Appl Psychol. 2009;58(1):1–23.

Article  Google Scholar 

Valente W. Social networks and health: models, methods, and applications. New York: Oxford Univ. Press; 2010.

Book  Google Scholar 

Whittingham M, Marmarosh CL, Mallow P, Scherer M. Mental health care equity and access: a group therapy solution. Am Psychol. 2023;78(2):119–33. https://doi.org/10.1037/amp0001078.

Article  PubMed  Google Scholar 

Janis RA, Burlingame GM, Svien H, Jensen J, Lundgreen R. Group therapy for mood disorders: a meta-analysis. Psychother Res. 2021;31(3):342–58. https://doi.org/10.1080/10503307.2020.1817603.

Article  PubMed  Google Scholar 

Polnay A, James VA, Hodges L, Murray GD, Munro C, Lawrie SM. Group therapy for people with bulimia nervosa: systematic review and meta-analysis. Psychol Med. 2014;44(11):2241–54. https://doi.org/10.1017/S0033291713002791.

Article  CAS  PubMed  Google Scholar 

Kaminer Y. Challenges and opportunities of group therapy for adolescent substance abuse: a critical review. Addict Behav. 2005;30(9):1765–74. https://doi.org/10.1016/j.addbeh.2005.07.002.

Article  PubMed  Google Scholar 

Burlingame GM, Svien H, Hoppe L, Hunt I, Rosendahl J. Group therapy for schizophrenia: a meta-analysis. Psychotherapy (Chic). 2020;57(2):219–36. https://doi.org/10.1037/pst0000293.

Article  PubMed  Google Scholar 

Hamilton AF. Hyperscanning: beyond the hype. Neuron. 2021;109(3):404–7.

Article  CAS  PubMed  Google Scholar 

• Shamay-Tsoory SG, Saporta N, Marton-Alper IZ, Gvirts HZ. Herding brains: a core neural mechanism for social alignment. Trends Cogn Sci. 2019;23(3):174–86. The authors of this article put out a paradigm that considers emotional contagion, social conformity, and coordinated movement as interconnected processes that depend on common brain networks. Expanding upon the predictive coding paradigm, we propose that a three-component feedback loop mediates social alignment: an alignment system that responds to misalignment, an error-monitoring system that keeps track of errors, and a reward system that kicks in when alignment is achieved. We characterize syndromes associated with herding (loneliness, autism) and advocate for novel research to explore the connections between the alignment levels.

Article  PubMed  Google Scholar 

Bhattacharya J. Cognitive neuroscience: synchronizing brains in the classroom. Curr Biol. 2017;27(9):R346–8.

Article  CAS  PubMed  Google Scholar 

Hasson U, Ghazanfar AA, Galantucci B, Garrod S, Keysers C. Brain-to-brain coupling: a mechanism for creating and sharing a social world. Trends Cogn Sci. 2012;16(2):114–21. https://doi.org/10.1016/j.tics.2011.12.007.

Article  PubMed  PubMed Central  Google Scholar 

Hari R, Kujala MV. Brain basis of human social interaction: from concepts to brain imaging. Physiol Rev. 2009;89:453–79.

Article  PubMed  Google Scholar 

Yamagishi A, Lee J, Sato N. Oxytocin in the anterior cingulate cortex is involved in helping behaviour. Behav Brain Res. 2020;393: 112790.

Article  CAS  PubMed  Google Scholar 

Ho SS, Macdonald A, Swain JE. Associative and sensorimotor learning for parenting involves mirror neurons under the influence of oxytocin. Behav Brain Sci. 2014;37(2):203–4.

Article  PubMed  PubMed Central  Google Scholar 

•• Vila A, Ardoy-Cuadros J, Romero-Moreno R, Nogales-Gonzalez C, Ritchey AJ, Sansoni M, Riva G. Body, emotions, and sexuality in the metaverse: a randomized control trial exploring the use of second life for an avatar-based intervention to support women with female orgasmic disorders. PsyArXiv Preprints. 2024. https://doi.org/10.31234/osf.io/qju56. This was the first RCT study to evaluate the effectiveness of an avatar-based intervention for female orgasmic dysfunction (FOD) sufferers. Based on the cognitive-behavioral and acceptance and commitment therapies, the avatar-based intervention comprised 12 weekly online individual sessions with the major goals of enhancing the FOD diagnosis, sexual satisfaction, function, and initiative, as well as sexual self-esteem, sexual guilt, and sexual anxiety. With respect to the control group, where traditional sexual coaching was delivered, the experimental group showed increased improvement in every sexual domain.

Article  Google Scholar 

Shifren JL, Monz BU, Russo PA, Segreti A, Johannes CB. Sexual problems and distress in United States women: prevalence and correlates. Obstet Gynecol. 2008;112(5):970–8. https://doi.org/10.1097/AOG.0b013e3181898cdb.

Article  PubMed  Google Scholar 

Brody S. Evaluation of female orgasmic disorder in W.W. IsHak (Ed.), The textbook of clinical sexual medicine (pp. 203–218). 2017. Springer International Publishing.

Riva G, Malighetti C, Serino S. Virtual reality in the treatment of eating disorders. Clin Psychol Psychother. 2021;28(3):477–88.

Article  PubMed  PubMed Central  Google Scholar 

Riva G, Wiederhold BK, Mantovani F. Neuroscience of virtual reality: from virtual exposure to embodied medicine. Cyberpsychol Behav Soc Netw. 2019;22(1):82–96.

Article  PubMed  PubMed Central  Google Scholar 

• Calabrò RS, Cerasa A, Ciancarelli I, Pignolo L, Tonin P, Iosa M, Morone G. The arrival of the metaverse in neurorehabilitation: fact, fake or vision? Biomedicines. 2022;17;10(10):2602. https://doi.org/10.3390/biomedicines10102602. In this perspective review, the authors proposed the future applications of metaverse-related technologies for improving motor and cognitive rehabilitation in neurological patients.

Article  Google Scholar 

Scarcella I, Marino F, Failla C, Doria G, Chilà P, Minutoli R, Vetrano N, Vagni D, Pignolo L, Di Cara M, Settimo C, Quartarone A, Cerasa A, Pioggia G. Information and communication technologies-based interventions for children with autism spectrum conditions: a systematic review of randomized control trials from a positive technology perspective. Front Psychiatry. 2023;14:1212522. https://doi.org/10.3389/fpsyt.2023.1212522.

Article  PubMed  PubMed Central  Google Scholar