Novel Strategies for Optimization of the Pre-transplant Donor Lung

Chambers DC, Cherikh WS, Goldfarb SB, Hayes D, Kucheryavaya AY, Toll AE, et al. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: thirty-fifth adult lung and heart-lung transplant report—2018; focus theme: multiorgan transplantation. J Heart Lung Transplant. 2018;37(10):1169–83.

Article  PubMed  Google Scholar 

Lentine KL, Smith JM, Miller JM, Bradbrook K, Larkin L, Weiss S, et al. OPTN/SRTR 2021 annual data report: kidney. Am J Transplant. 2023;23(2):S21-120.

Article  PubMed  PubMed Central  Google Scholar 

Valapour M, Skeans MA, Smith JM, Edwards LB, Cherikh WS, Uccellini K, et al. OPTN/SRTR 2015 annual data report: lung. Am J Transplant Off J Am Soc Transplant Am Soc Transpl Surg. 2017;17(Suppl 1):357–424.

Article  Google Scholar 

Stewart D, Hasz R, Lonze B. Beyond donation to organ utilization in the USA. Curr Opin Organ Transplant. 2023;28(3):197–206.

Article  PubMed  Google Scholar 

Mulvihill M, Lee H, Weber J, Choi A, Cox M, Yerokun B, et al. Variability in donor organ offer acceptance and lung transplantation survival. J Heart Lung Transplant Off Publ Int Soc Heart Transplant. 2020;39(4):353–62.

Article  Google Scholar 

De Meester J, Smits JM, Persijn GG, Haverich A. Lung transplant waiting list: differential outcome of type of end-stage lung disease, one year after registration. J Heart Lung Transplant Off Publ Int Soc Heart Transplant. 1999;18(6):563–71.

Article  Google Scholar 

Sundaresan S, Trachiotis GD, Aoe M, Patterson GA, Cooper JD. Donor lung procurement: assessment and operative technique. Ann Thorac Surg. 1993;56(6):1409–13.

Article  CAS  PubMed  Google Scholar 

Reul RM, Loor G, Garcha PS, Goss JA, Rana AA. Allograft discard risk index for lung transplantation. J Heart Lung Transplant Off Publ Int Soc Heart Transplant. 2021;40(12):1658–67.

Article  Google Scholar 

Chambers DC, Zuckermann A, Cherikh WS, Harhay MO, Hayes D, Hsich E, et al. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: 37th adult lung transplantation report - 2020; focus on deceased donor characteristics. J Heart Lung Transplant Off Publ Int Soc Heart Transplant. 2020;39(10):1016–27.

Article  Google Scholar 

Meers C, Van Raemdonck D, Verleden GM, Coosemans W, Decaluwe H, De Leyn P, et al. The number of lung transplants can be safely doubled using extended criteria donors; a single-center review. Transpl Int Off J Eur Soc Organ Transplant. 2010;23(6):628–35.

Google Scholar 

Stehlik J, Smits J, Jarcho JA, Lehman R, Cherikh W, Mehra MR. The opioid use crisis and organ transplantation: a comparison of the United States and Europe. J Heart Lung Transplant. 2018;37(4):S188.

Article  Google Scholar 

Woolley AE, Singh SK, Goldberg HJ, Mallidi HR, Givertz MM, Mehra MR, et al. Heart and lung transplants from HCV-infected donors to uninfected recipients. N Engl J Med. 2019;380(17):1606–17.

Article  PubMed  PubMed Central  Google Scholar 

Lewis TC, Lesko M, Rudym D, Lonze BE, Mangiola M, Natalini JG, et al. One-year immunologic outcomes of lung transplantation utilizing hepatitis C-viremic donors. Clin Transplant. 2022;36(8): e14749.

Article  PubMed  Google Scholar 

• Li SS, Osho A, Moonsamy P, Wolfe S, Villavicencio MA, Langer N, et al. Outcomes of lung transplantation from hepatitis C viremic donors. Ann Thorac Surg. 2022;113(5):1598–607. Outcomes of lung transplantation from hepatitis C viremic donors.

Article  PubMed  Google Scholar 

Aslam S, Grossi P, Schlendorf KH, Holm AM, Woolley AE, Blumberg E, et al. Utilization of hepatitis C virus-infected organ donors in cardiothoracic transplantation: an ISHLT expert consensus statement. J Heart Lung Transplant Off Publ Int Soc Heart Transplant. 2020;39(5):418–32.

Article  Google Scholar 

Avlonitis VS, Fisher AJ, Kirby JA, Dark JH. Pulmonary transplantation: the role of brain death in donor lung injury. Transplantation. 2003;75(12):1928–33.

Article  PubMed  Google Scholar 

Nijboer WN, Schuurs TA, van der Hoeven J, Leuvenink HGD, van der Heide JJH, van Goor H, et al. Effects of brain death on stress and inflammatory response in the human donor kidney. Transplant Proc. 2005;37(1):367–9.

Article  CAS  PubMed  Google Scholar 

Krutsinger D, Reed RM, Blevins A, Puri V, De Oliveira NC, Zych B, et al. Lung transplantation from donation after cardiocirculatory death: a systematic review and meta-analysis. J Heart Lung Transplant Off Publ Int Soc Heart Transplant. 2015;34(5):675–84.

Article  Google Scholar 

Van Raemdonck D, Keshavjee S, Levvey B, Cherikh WS, Snell G, Erasmus M, et al. Donation after circulatory death in lung transplantation-five-year follow-up from ISHLT Registry. J Heart Lung Transplant Off Publ Int Soc Heart Transplant. 2019;38(12):1235–45.

Article  Google Scholar 

Siddique A, Urban M, Strah H, Herber K, Morrow L, Loor G, et al. Controlled DCD lung transplantation: circumventing imagined and real barriers-time for an international taskforce? J Heart Lung Transplant Off Publ Int Soc Heart Transplant. 2022;41(9):1198–203.

Article  Google Scholar 

Choi K, Spadaccio C, Villavicencio M, Langlais B, Pennington K, Ribeiro R, et al. (257) National trends of lung allograft utilization during donation-after-circulatory-death (DCD) heart procurement in the United States. J Heart Lung Transplant. 2023;42(4, Supplement):S124.

Article  Google Scholar 

Cypel M, Rubacha M, Yeung J, Hirayama S, Torbicki K, Madonik M, et al. Normothermic ex vivo perfusion prevents lung injury compared to extended cold preservation for transplantation. Am J Transplant. 2009;9(10):2262–9.

Article  CAS  PubMed  Google Scholar 

Jirsch DW, Fisk RL, Couves CM. Ex vivo evaluation of stored lungs. Ann Thorac Surg. 1970;10(2):163–8.

Article  CAS  PubMed  Google Scholar 

Steen S, Sjöberg T, Pierre L, Liao Q, Eriksson L, Algotsson L. Transplantation of lungs from a non-heart-beating donor. Lancet Lond Engl. 2001;357(9259):825–9.

Article  CAS  Google Scholar 

Steen S, Ingemansson R, Eriksson L, Pierre L, Algotsson L, Wierup P, et al. First human transplantation of a nonacceptable donor lung after reconditioning ex vivo. Ann Thorac Surg. 2007;83(6):2191–4.

Article  PubMed  Google Scholar 

Gouin C, Vu Manh TP, Jouneau L, Bevilacqua C, De Wolf J, Glorion M, et al. Cell type- and time-dependent biological responses in ex vivo perfused lung grafts. Front Immunol. 2023;14:1142228.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yeung JC, Zamel R, Klement W, Bai XH, Machuca TN, Waddell TK, et al. Towards donor lung recovery—gene expression changes during ex vivo lung perfusion of human lungs. Am J Transplant. 2018;18(6):1518–26.

Article  CAS  PubMed  Google Scholar 

Yeung JC, Cypel M, Machuca TN, Koike T, Cook DJ, Bonato R, et al. Physiologic assessment of the ex vivo donor lung for transplantation. J Heart Lung Transplant. 2012;31(10):1120–6.

Article  PubMed  Google Scholar 

Takahashi M, Cheung HYA, Watanabe T, Zamel R, Cypel M, Liu M, et al. Strategies to prolong homeostasis of ex vivo perfused lungs. J Thorac Cardiovasc Surg. 2021;161(6):1963–73.

Article  PubMed  Google Scholar 

Van De Wauwer C, van Suylen V, Zhang ZL, Verschuuren EAM, van der Bij W, Gan CT, et al. Is logistically motivated ex vivo lung perfusion a good idea? Front Transplant. 2022. https://doi.org/10.3389/frtra.2022.988950.

Article  Google Scholar 

Cypel M, Yeung JC, Liu M, Anraku M, Chen F, Karolak W, et al. Normothermic ex vivo lung perfusion in clinical lung transplantation. N Engl J Med. 2011;364(15):1431–40.

Article  CAS  PubMed  Google Scholar 

Sanchez PG, Cantu E, Hartwig M, D’Ovidio F, Machuca T, Whitson B, et al. The NOVEL Study. A multi-center clinical trial studying the safety of ex vivo lung perfusion. J Heart Lung Transplant. 2020;39(4):S110.

Article  Google Scholar 

Warnecke G, Van Raemdonck D, Smith MA, Massard G, Kukreja J, Rea F, et al. Normothermic ex-vivo preservation with the portable Organ Care System Lung device for bilateral lung transplantation (INSPIRE): a randomised, open-label, non-inferiority, phase 3 study. Lancet Respir Med. 2018;6(5):357–67.

Article  PubMed  Google Scholar 

Loor G, Warnecke G, Villavicencio MA, Smith MA, Kukreja J, Ardehali A, et al. Portable normothermic ex-vivo lung perfusion, ventilation, and functional assessment with the Organ Care System on donor lung use for transplantation from extended-criteria donors (EXPAND): a single-arm, pivotal trial. Lancet Respir Med. 2019;7(11):975–84.

Article  PubMed  Google Scholar 

Choi K. National trends in utilization of ex-vivo lung perfusion in lung transplantation [Internet]. Mechanical Support and Thoracic Transplantation Summit. The Omni King Edward Hotel, Toronto, ON, Canada. 2023. Available from: https://www.aats.org/resources/national-trends-in-utilization-of-ex-vivo-lung-perfusion-in-lung-transplantation.

Cypel M, Yeung JC, Donahoe L, Chen M, Zamel R, Hoetzenecker K, et al. Normothermic ex vivo lung perfusion: does the indication impact organ utilization and patient outcomes after transplantation? J Thorac Cardiovasc Surg. 2020;159(1):346-355.e1.

Article  CAS  PubMed  Google Scholar 

Peel JK, Keshavjee S, Naimark D, Liu M, Sorbo LD, Cypel M, et al. Determining the impact of ex-vivo lung perfusion on hospital costs for lung transplantation: a retrospective cohort study. J Heart Lung Transplant. 2023;42(3):356–67.

Article  PubMed  Google Scholar 

• Chen Q, Malas J, Krishnan A, Thomas J, Megna D, Egorova N, et al. Limited cumulative experience with ex vivo lung perfusion is associated with inferior outcomes after lung transplantation. J Thorac Cardiovasc Surg. 2024;167(1):371–379.e8. This paper highlights that despite increasing interest and use of EVLP systems, transplant outcomes remain highly linked to the experience of the team conducting EVLP. Notably this remains a substantial limitation of the platform and currently limits widespread adoption.

Article  PubMed  Google Scholar 

• Mallea JM, Hartwig MG, Keller CA, Kon Z, Iii RNP, Erasmus DB, et al. Remote ex vivo lung perfusion at a centralized evaluation facility. J Heart Lung Transplant Off Publ Int Soc Heart Transplant. 2022;41(12):1700–11. This paper highlights that as cost and efficacy of using EVLP systems remains a challenge, centralization of EVLP at specialized centers may serve as a better method to improved lung recovery and utilization of EVLP to enable more transplants.

Article  Google Scholar 

Nakajima D, Cypel M, Bonato R, Machuca TN, Iskender I, Hashimoto K, et al. Ex vivo perfusion treatment of infection in human donor lungs. Am J Transplant Off J Am Soc Transplant Am Soc Transpl Surg. 2016;16(4):1229–37.

Article  CAS 

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