1   Department of Medicine, Division of Gastroenterology, Jichi Medical University, Shimotsuke, Japan (Ringgold ID: RIN12838)

2   Department of Gastroenterology, Jyoban Hospital of Tokiwa Foundation, Iwaki, Japan

,

Daiki Nemoto

3   Department of Coloproctology, Fukushima Medical University Aizu Medical Center, Fukushima, Japan (Ringgold ID: RIN38219)

4   Department of Gastroenterology, Takeda General Hospital, Fukushima, Japan

,

Tomohiro Kurokawa

2   Department of Gastroenterology, Jyoban Hospital of Tokiwa Foundation, Iwaki, Japan

,

5   Division of Gastroenterology and Hepatology,, Kansai Medical University Medical Center, Moriguchi, Japan (Ringgold ID: RIN50196)

,

1   Department of Medicine, Division of Gastroenterology, Jichi Medical University, Shimotsuke, Japan (Ringgold ID: RIN12838)

,

1   Department of Medicine, Division of Gastroenterology, Jichi Medical University, Shimotsuke, Japan (Ringgold ID: RIN12838)

,

Masahiro Okada

1   Department of Medicine, Division of Gastroenterology, Jichi Medical University, Shimotsuke, Japan (Ringgold ID: RIN12838)

,

Takahito Takezawa

1   Department of Medicine, Division of Gastroenterology, Jichi Medical University, Shimotsuke, Japan (Ringgold ID: RIN12838)

,

Yuki Nakajima

3   Department of Coloproctology, Fukushima Medical University Aizu Medical Center, Fukushima, Japan (Ringgold ID: RIN38219)

,

Yuka Kowazaki

2   Department of Gastroenterology, Jyoban Hospital of Tokiwa Foundation, Iwaki, Japan

,

Hisashi Fukuda

1   Department of Medicine, Division of Gastroenterology, Jichi Medical University, Shimotsuke, Japan (Ringgold ID: RIN12838)

2   Department of Gastroenterology, Jyoban Hospital of Tokiwa Foundation, Iwaki, Japan

,

1   Department of Medicine, Division of Gastroenterology, Jichi Medical University, Shimotsuke, Japan (Ringgold ID: RIN12838)

6   Department of Gastroenterology, Mie Prefectural Shima Hospital, Shima, Japan (Ringgold ID: RIN38367)

,

7   Royal Free Unit for Endoscopy, The Royal Free Hospital and University College London (UCL) Institute for Liver and Digestive Health, London, UK

,

Noriyoshi Fukushima

8   Department of Pathology, Jichi Medical University, Shimotsuke, Japan (Ringgold ID: RIN12838)

,

1   Department of Medicine, Division of Gastroenterology, Jichi Medical University, Shimotsuke, Japan (Ringgold ID: RIN12838)

,

1   Department of Medicine, Division of Gastroenterology, Jichi Medical University, Shimotsuke, Japan (Ringgold ID: RIN12838)

Clinical Trial: Registration number (trial ID): UMIN000044059, Trial registry: UMIN Japan (http://www.umin.ac.jp/english/), Type of Study: Prospective, Randomized, Multi-Center Study