1   School of Life Sciences and Engineering, Southwest Jiaotong University, Chengdu, China

2   State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

,

2   State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

3   Department of Hematopathololgy, Tianjin Institutes of Health Science, Tianjin, China

,

Jie Li

4   Department of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, China

,

Shicai Xu

2   State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

3   Department of Hematopathololgy, Tianjin Institutes of Health Science, Tianjin, China

,

Zhijian Xiao

2   State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

3   Department of Hematopathololgy, Tianjin Institutes of Health Science, Tianjin, China

,

1   School of Life Sciences and Engineering, Southwest Jiaotong University, Chengdu, China

,

2   State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

3   Department of Hematopathololgy, Tianjin Institutes of Health Science, Tianjin, China

,

2   State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

3   Department of Hematopathololgy, Tianjin Institutes of Health Science, Tianjin, China

This work was supported by the CAMS Innovation Fund for Medical Sciences (2021-I2M-1-041 [to S.Q.R.]; 2022-I2M-1-022 [to Z.J.X.]), the National Key Research and Development Program of China (2021YFA1102300 [to S.Q.R.]), the Tianjin Municipal Science and Technology Commission Grant (21JCQNJC01220 [to S.Q.R.]), the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2021-RC310-015 [to S.Q.R.]), the Basic Research Cultivation Support Program of Fundamental Research Funds for the Central Universities (2682023ZTPY071 [to Z.Y.G.]).