In recent years, the use of music as a therapeutic and developmental tool for infants, especially within neonatal intensive care units (NICUs), has seen a surge in interest. Despite a growing body of research underscoring the potential benefits of music therapy and music medicine in enhancing infant development and aiding medical practices, the specific characteristics of music that maximize these benefits remain poorly understood. This systematic review aims to fill this gap by investigating the effects of passive music listening on the development and medical outcomes of infants, both full-term and premature. Following the PRISMA guidelines, a comprehensive literature search was conducted, covering studies published up until December 2022. The focus was on passive music listening, with a deliberate exclusion of active music interventions. Out of the initial pool of studies, 56 met the inclusion criteria, determined by the PICO framework, focusing on passive music exposure among full-term and preterm infants. Starting with a descriptive analysis approach, the study employed Non-negative Matrix Factorization (NMF) and Latent Dirichlet Allocation (LDA) to identify key themes, including the physiological impacts of music, its role in pain management, effects on sleep and stress, and influences on feeding and weight gain. The review revealed a predominance of quantitative research methods, a significant concentration of studies from the United States, suggesting potential geographical bias, and a notable clinical setting bias. These findings indicate a critical need for methodological diversity and a more culturally inclusive and interdisciplinary approach to research. Although this systematic review highlights the beneficial role of passive music listening in pediatric care, it also points to the necessity for standardized music intervention protocols to optimize therapeutic and developmental outcomes for this vulnerable population. Future research should aim to bridge the methodological gaps identified, integrating both qualitative and quantitative approaches to provide a comprehensive understanding of music's impact on infant development and medical practices in a global, culturally nuanced context.

The authors have declared no competing interest.

This study did not receive any funding

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All data produced in the present study are available upon reasonable request to the authors