Hussein YM, Mohamed RH, Shalaby SM, Abd El-Haleem MR, Abd El Motteleb DM. Anti-oxidative and anti-apoptotic roles of spermatogonial stem cells in reversing cisplatin-induced testicular toxicity. Cytotherapy. 2015; 17(11):1646–54. doi: https://doi.org/10.1016/j.jcyt.2015.07.001.
Aldemir M, Okulu EM, Kösemehmetoğlu KE, Ener K, Topal F, Evirgen O, et al. Evaluation of the protective effect of quercetin against cisplatin-induced renal and testis tissue damage and sperm parameters in rats. Andrologia. 2014;46(10):1089–97.
Article CAS PubMed Google Scholar
Aly HAA, Eid BG. Cisplatin induced testicular damage through mitochondria mediated apoptosis, inflammation and oxidative stress in rats: impact of resveratrol. Endocr J. 2020;67(9):969–80. https://doi.org/10.1507/endocrj.EJ20-0149.
Nna VU, Ujah GA, Suleiman JB, Mohamed M, Nwokocha C, Akpan TJ, et al. Tert-butylhydroquinone preserve testicular steroidogenesis and spermatogenesis in cisplatin-intoxicated rats by targeting oxidative stress, inflammation and apoptosis. Toxicology. 2020;441:152528. https://doi.org/10.1016/j.tox.2020.152528.
Article CAS PubMed Google Scholar
Saher F, Ijaz MU, Hamza A, Ain QU, Hayat MF, Afsar T, et al. Mitigative potential of rhoifolin against cisplatin prompted testicular toxicity: biochemical, spermatogenic and histological based analysis. Toxicol Res (Camb). 2023;12(5):814–23. https://doi.org/10.1093/toxres/tfad073.
Demir M, Altındağ F. Sinapic acid ameliorates cisplatin-induced disruptions in testicular steroidogenesis and spermatogenesis by modulating androgen receptor, proliferating cell nuclear antigen and apoptosis in male rats. Andrologia. 2022;54(4):e14369. https://doi.org/10.1111/and.14369.
Article CAS PubMed Google Scholar
Datrianto DS, Budipitojo T, Prihatno SA. Secretome improves testosterone and androgen-binding protein production in testicular dysfunction rats induced by cisplatin. J Adv Vet Anim Res. 2021;8(4):687–94. https://doi.org/10.5455/javar.2021.h561.
Article PubMed PubMed Central Google Scholar
Soni KK, Kim HK, Choi BR, Karna KK, You JH, Cha JS, et al. Dose-dependent effects of cisplatin on the severity of testicular injury in Sprague Dawley rats: reactive oxygen species and endoplasmic reticulum stress. Drug Des Dev Ther. 2016;10:3959–68.
Sharma P, Kaushal N, Saleth LR, Ghavami S, Dhingra S, Kaur P. Oxidative stress-induced apoptosis and autophagy: balancing the contrary forces in spermatogenesis. Biochim Biophys Acta Mol Basis Dis. 2023;1869(6):166742. https://doi.org/10.1016/j.bbadis.2023.166742.
Article CAS PubMed Google Scholar
Wang M, Zeng L, Su P, Ma L, Zhang M, Zhang YZ. Autophagy: a multifaceted player in the fate of sperm. Hum Reprod Update. 2022;28(2):200–31. https://doi.org/10.1093/humupd/dmab043.
Article CAS PubMed Google Scholar
Aparicio IM, Espino J, Bejarano I, Gallardo-Soler A, Campo ML, Salido GM, et al. Autophagy-related proteins are functionally active in human spermatozoa and may be involved in the regulation of cell survival and motility. Sci Rep. 2016;6:33647. https://doi.org/10.1038/srep33647.
Article CAS PubMed PubMed Central Google Scholar
Yang P, Ahmed N, Wang L, Chen H, Waqas Y, Liu T, et al. In vivo autophagy and biogenesis of autophagosomes within male haploid cells during spermiogenesis. Oncotarget. 2017;8(34):56791–801. https://doi.org/10.18632/oncotarget.18221.
Article PubMed PubMed Central Google Scholar
Shang Y, Wang H, Jia P, Zhao H, Liu C, et al. Autophagy regulates spermatid differentiation via degradation of PDLIM1. Autophagy. 2016;12:1575–92.
Article CAS PubMed PubMed Central Google Scholar
Chen H, Wang Y, Luo J, Kang M, Hou J, Tang R, et al. Autophagy and apoptosis mediated nano-copper-induced testicular damage. Ecotoxicol Environ Saf. 2022;229:113039. https://doi.org/10.1016/j.ecoenv.2021.113039.
Article CAS PubMed Google Scholar
Ali W, Deng K, Sun J, Ma Y, Liu Z, Zou H. A new insight of cadmium-induced cellular evidence of autophagic-associated spermiophagy during spermatogenesis. Environ Sci Pollut Res Int. 2023;30(45):101064–74. https://doi.org/10.1007/s11356-023-29548-9.
Article CAS PubMed Google Scholar
Akarsu SA, Gür C, İleritürk M, Akaras N, Küçükler S, Kandemir FM. Effect of syringic acid on oxidative stress, autophagy, apoptosis, inflammation pathways against testicular damage induced by lead acetate. J Trace Elem Med Biol. 2023;80:127315. https://doi.org/10.1016/j.jtemb.2023.127315.
Article CAS PubMed Google Scholar
Gan Y, Yang D, Yang S, Wang J, Wei J, Chen J. Di-2-ethylhexyl phthalate (DEHP) induces apoptosis and autophagy of mouse GC-1 spg cells. Environ Toxicol. 2020;35(2):292–9. https://doi.org/10.1002/tox.22866.
Article CAS PubMed Google Scholar
Wu S, Zhong G, Wan F, Jiang X, Tang Z, Hu T, et al. Evaluation of toxic effects induced by arsenic trioxide or/and antimony on autophagy and apoptosis in testis of adult mice. Environ Sci Pollut Res Int. 2021;28(39):54647–60. https://doi.org/10.1007/s11356-021-14486-1.
Article CAS PubMed Google Scholar
Huang W, Cao Z, Zhang J, Ji Q, Li Y. Aflatoxin B1 promotes autophagy associated with oxidative stress-related PI3K/AKT/mTOR signaling pathway in mice testis. Environ Poll. 2019;255(2):113317. https://doi.org/10.1016/j.envpol.2019.113317.
Rotimi DE, Singh SK. Interaction between apoptosis and autophagy in testicular function. Andrologia. 2022;54(11):e14602. https://doi.org/10.1111/and.14602.
Vardiyan R, Ezati D, Anvari M, Ghasemi N, Talebi A. Effect of L-carnitine on the expression of the apoptotic genes Bcl-2 and Bax. Clin Exp Reprod Med. 2020;47(3):155–60. https://doi.org/10.5653/cerm.2019.03440.
Article PubMed PubMed Central Google Scholar
Hatok J, Racay P. Bcl-2 family proteins: master regulators of cell survival. Biomol Concepts. 2016;7(4):259–70. https://doi.org/10.1515/bmc-2016-0015.
Article CAS PubMed Google Scholar
Shahedi A, Talebi AR, Mirjalili A, Pourentezari M. Protective effects of curcumin on chromatin quality, sperm parameters, and apoptosis following testicular torsion-detorsion in mice. Clin Exp Reprod Med. 2021;48(1):27–33. https://doi.org/10.5653/cerm.2020.03853.
Article PubMed PubMed Central Google Scholar
Behairy A, Hashem MM, Abo-El-Sooud K, El-Metwally AE, Hassan BA, Abd-Elhakim YM. Quercetin abates aluminum trioxide nanoparticles and lead acetate induced altered sperm quality, testicular oxidative damage, and sexual hormones disruption in male rats. Antioxidants (Basel). 2022;11(11):2133. https://doi.org/10.3390/antiox11112133.
Article CAS PubMed Google Scholar
Rotimi DE, Elebiyo TC, Ojo OA. Therapeutic potential of rutin in male infertility: a mini review. J Integr Med. 2023;21(2):130–5. https://doi.org/10.1016/j.joim.2023.01.004.
YaghutianNezhad L, MohseniKouchesfahani H, Alaee S, Bakhtari A. Thymoquinone ameliorates bleomycin-induced reproductive toxicity in male Balb/c mice. Hum Exp Toxicol. 2021;40(12):S611–21. https://doi.org/10.1177/09603271211048184.
Asadi N, Bahmani M, Kheradmand A, Rafieian-Kopaei M. The impact of oxidative stress on testicular function and the role of antioxidants in improving it: a review. J Clin Diagn Res. 2017;11(5):IE01–5. https://doi.org/10.7860/JCDR/2017/23927.9886.
Article CAS PubMed PubMed Central Google Scholar
Mesbahzadeh B, Hassanzadeh-Taheri M, Aliparast MS, Baniasadi P, Mehran HM. The protective effect of crocin on cisplatin-induced testicular impairment in rats. BMC Urol. 2021;21(1):117. https://doi.org/10.1186/s12894-021-00889-2.
Article CAS PubMed PubMed Central Google Scholar
Geng W, Li C, Zhan Y, Zhang R, Zheng J. Thymoquinone alleviates liver fibrosis via miR-30a-mediated epithelial-mesenchymal transition. J Cell Physiol. 2020. https://doi.org/10.1002/jcp.30097.
Hannan MA, Zahan MS, Sarker PP, Moni A, Ha H, Uddin MJ. Protective effects of black cumin (Nigella sativa) and its bioactive constituent, thymoquinone against kidney injury: an aspect on pharmacological insights. Int J Mol Sci. 2021;22(16):9078.
Article CAS PubMed PubMed Central Google Scholar
Kohandel Z, Farkhondeh T, Aschner M, Samarghandian S. Anti-inflammatory effects of thymoquinone and its protective effects against several diseases. Biomed Pharmacother. 2021;138:111492. https://doi.org/10.1016/j.biopha.2021.111492.
Article CAS PubMed Google Scholar
Algaidi SA, Faddladdeen KA, Alrefaei GI, Qahl SH, Albadawi EA, ALmohaimeed HM, et al. Thymoquinone protects the testes of hypothyroid rats by suppressing pro-inflammatory cytokines and oxidative stress and promoting SIRT1 testicular expression. Front Pharmacol. 2022;13:1040857. https://doi.org/10.3389/fphar.2022.1040857.
Article CAS PubMed PubMed Central Google Scholar
Gur FM, Timurkaan S, Taskin E, Guven C, Gur HE, Senturk M. Thymoquinone improves testicular damage and sperm quality in experimentally varicocele-induced adolescent rats. Andrologia. 2021;53:(5):e14033. https://doi.org/10.1111/and.14033.
Savran M, Ascı H, Armagan I, Erzurumlu Y, Azırak S, Ozer MK, et al. Thymoquinone could be protective against valproic acid-induced testicular toxicity by antioxidant and anti-inflammatory mechanisms. Andrologia. 2020;52:(7):e13623. https://doi.org/10.1111/and.13623.
Sheikhbahaei F, Khazaei M, Rabzia A, Mansouri K, Ghanbari A. Protective effects of thymoquinone against methotrexate-induced germ cell apoptosis in male mice. Int J Fertil Steril. 2016;9(4):541–7.
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