In the present work, self-adhesive and self-healing drug loaded poly (hydroxyethyl methacrylate-acrylamide)/gelatin hydrogels with dual networks were synthesized by a facile one-pot method crosslinked with dynamic hydrogen bond and metal-ligand interactions. The prepared hydrogels displayed excellent cyclic adhesion performance on various surface due to the presence of Fe3+ ion and tannic acid (TA). Notably, due to the uniform compact pore size distribution, the prepared P(HEMA-AM)/Gel0.9 hydrogel possessed the most effective improvement in physicochemical properties, with a tensile strength of 305 kPa and an elongation at break of 589% in tensile experiments, and a compressive strength of 1.11 MPa at 70% strain. At the same time, the self-healing efficiency of P(HEMA-AM)/Gel0.9 hydrogel can be reach 95 % after 24 h repair. Furthermore, drug release experiments showed that the hydrogels had pH-responsive and sustained drug release properties, and the addition of gelatin in the composite hydrogel would accelerated drug release. Therefore, P(HEMA-AM)/Gel hydrogel fabricated with convenient and simple method possess great potential to be used in drug delivery system.

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