Complex interplay of neurodevelopmental disorders (NDDs), fractures, and osteoporosis: a mendelian randomization study

Jain P, Miller-Fleming T, Topaloudi A, Yu D, Drineas P, Georgitsi M, Yang Z, Rizzo R, Müller-Vahl KR, Tumer Z et al. Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome. Translational Psychiatry 2023, 13(1).

Whitney DG, Caird MS, Jepsen KJ, Kamdar NS, Marsack-Topolewski CN, Hurvitz EA, Peterson MD. Elevated fracture risk for adults with neurodevelopmental disabilities. Bone 2020, 130.

Chou IC, Lin CC, Sung FC, Kao CH. Attention-deficit‐hyperactivity disorder increases risk of bone fracture: a population‐based cohort study. Dev Med Child Neurol. 2014;56(11):1111–6.

Article  PubMed  Google Scholar 

Perry BA, Archer KR, Song Y, Ma Y, Green JK, Elefteriou F, Dahir KM. Medication therapy for attention deficit/hyperactivity disorder is associated with lower risk of fracture: a retrospective cohort study. Osteoporos Int. 2016;27(7):2223–7.

Article  CAS  PubMed  Google Scholar 

Guo N-W, Lin C-L, Lin C-W, Huang M-T, Chang W-L, Lu T-H, Lin C-J. Fracture risk and correlating factors of a pediatric population with attention deficit hyperactivity disorder: a nationwide matched study. J Pediatr Orthop B. 2016;25(4):369–74.

Article  PubMed  Google Scholar 

Prasad V, West J, Sayal K, Kendrick D. Injury among children and young people with and without attention-deficit hyperactivity disorder in the community: the risk of fractures, thermal injuries, and poisonings. Child Care Health Dev. 2018;44(6):871–8.

Article  PubMed  Google Scholar 

Merrill RM, Lyon JL, Baker RK, Gren LH. Attention deficit hyperactivity disorder and increased risk of injury. Adv Med Sci. 2009;54(1):20–6.

Article  CAS  PubMed  Google Scholar 

Kömürcü E, Bilgiç A, Hergüner S. Relationship between extremity fractures and attention-deficit/hyperactivity disorder symptomatology in adults. Int J Psychiatry Med. 2014;47(1):55–63.

Article  PubMed  Google Scholar 

Jacob L, Kostev K. Impact of attention deficit hyperactivity disorder therapy on fracture risk in children treated in German pediatric practices. Osteoporos Int. 2017;28(4):1265–9.

Article  CAS  PubMed  Google Scholar 

Ziv-Baran T, Zacay G, Modan-Moses D, Reingold SM, Mekori E, Levy-Shraga Y. Increased fracture risk among children diagnosed with attention- deficit/hyperactivity disorder: a large matched cohort study. Eur J Pediatrics. 2023;182(6):2705–14.

Article  Google Scholar 

Hashem S, Nisar S, Bhat AA, Yadav SK, Azeem MW, Bagga P, Fakhro K, Reddy R, Frenneaux MP, Haris M. Genetics of structural and functional brain changes in autism spectrum disorder. Translational Psychiatry 2020, 10(1).

McDermott S, Zhou L, Mann J. Injury Treatment among children with autism or pervasive developmental disorder. J Autism Dev Disord. 2007;38(4):626–33.

Article  PubMed  Google Scholar 

Neumeyer AM, O’Rourke JA, Massa A, Lee H, Lawson EA, McDougle CJ, Misra M. Brief report: bone fractures in children and adults with Autism Spectrum disorders. J Autism Dev Disord. 2014;45(3):881–7.

Article  Google Scholar 

Ekhlaspour L, Baskaran C, Campoverde KJ, Sokoloff NC, Neumeyer AM, Misra M. Bone density in adolescents and young adults with Autism Spectrum disorders. J Autism Dev Disord. 2016;46(11):3387–91.

Article  PubMed  PubMed Central  Google Scholar 

Rostami Haji Abadi M, Neumeyer A, Misra M, Kontulainen S. Bone health in children and youth with ASD: a systematic review and meta-analysis. Osteoporos Int. 2021;32(9):1679–91.

Article  CAS  PubMed  Google Scholar 

Lu Y-Y, Wang M-Y, Wei IH, Lin C-C, Huang C-C. Tourette syndrome increases risk of bone fractures: a population-based cohort study. Eur Child Adolesc Psychiatry. 2016;26(5):531–9.

Article  PubMed  Google Scholar 

Armenteros JL, Davies M. Antipsychotics in early onset Schizophrenia. Eur Child Adolesc Psychiatry. 2006;15(3):141–8.

Article  PubMed  Google Scholar 

Kanis JA. Diagnosis of osteoporosis and assessment of fracture risk. Lancet. 2002;359(9321):1929–36.

Article  PubMed  Google Scholar 

Wilson-Barnes SL, Lanham-New SA, Lambert H. Modifiable risk factors for bone health & fragility fractures. Best Pract Res Clin Rheumatol 2022, 36(3).

Boudin E, Fijalkowski I, Hendrickx G, Van Hul W. Genetic control of bone mass. Mol Cell Endocrinol. 2016;432:3–13.

Article  CAS  PubMed  Google Scholar 

Cosman F, de Beur SJ, LeBoff MS, Lewiecki EM, Tanner B, Randall S, Lindsay R. Clinician’s guide to Prevention and treatment of osteoporosis. Osteoporos Int. 2014;25(10):2359–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Denova-Gutiérrez E, Méndez-Sánchez L, Muñoz-Aguirre P, Tucker KL, Clark P. Dietary patterns, bone Mineral Density, and risk of fractures: a systematic review and Meta-analysis. Nutrients 2018, 10(12).

Lane JC, Butler KL, Poveda-Marina JL, Martinez-Laguna D, Reyes C, de Bont J, Javaid MK, Logue J, Compston JE, Cooper C, et al. Preschool obesity is Associated with an increased risk of Childhood fracture: a longitudinal cohort study of 466,997 children and up to 11years of follow-up in Catalonia, Spain. J Bone Min Res. 2020;35(6):1022–30.

Article  Google Scholar 

Jia N, Dong L, Lu Q, Li X, Jin M, Yin X, Zhu Z, Jia Q, Ji C, Hui L, et al. The causal effect of schizophrenia on fractures and bone mineral density: a comprehensive two-sample mendelian randomization study of European ancestry. BMC Psychiatry. 2023;23(1):692.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Diagnostic and statistical manual of mental disorders: DSM-5™, 5th ed. In: Diagnostic and statistical manual of mental disorders: DSM-5™, 5th ed. Arlington, VA, US: American Psychiatric Publishing, Inc. 2013: xliv, 947-xliv, 947.

Åsberg Johnels J, Yngvesson P, Billstedt E, Gillberg C, Halldner L, Råstam M, Gustafsson P, Selinus EN, Lichtenstein P, Hellner C, et al. The relationship between intelligence and global adaptive functioning in young people with or without neurodevelopmental disorders. Psychiatry Res. 2021;303:114076.

Article  PubMed  Google Scholar 

Davey Smith G, Hemani G. Mendelian randomization: genetic anchors for causal inference in epidemiological studies. Hum Mol Genet. 2014;23(R1):R89–98.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Richmond RC, Anderson EL, Dashti HS, Jones SE, Lane JM, Strand LB, Brumpton B, Rutter MK, Wood AR, Straif K et al. Investigating causal relations between sleep traits and risk of breast cancer in women: mendelian randomisation study. BMJ 2019.

Demontis D, Walters GB, Athanasiadis G, Walters R, Therrien K, Nielsen TT, Farajzadeh L, Voloudakis G, Bendl J, Zeng B, et al. Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains. Nat Genet. 2023;55(2):198–208.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grove J, Ripke S, Als TD, Mattheisen M, Walters RK, Won H, Pallesen J, Agerbo E, Andreassen OA, Anney R, et al. Identification of common genetic risk variants for autism spectrum disorder. Nat Genet. 2019;51(3):431–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu D, Sul JH, Tsetsos F, Nawaz MS, Huang AY, Zelaya I, Illmann C, Osiecki L, Darrow SM, Hirschtritt ME, et al. Interrogating the genetic determinants of Tourette’s syndrome and other Tic disorders through genome-wide Association studies. Am J Psychiatry. 2019;176(3):217–27.

Article  PubMed  PubMed Central  Google Scholar 

Savage JE, Jansen PR, Stringer S, Watanabe K, Bryois J, de Leeuw CA, Nagel M, Awasthi S, Barr PB, Coleman JRI, et al. Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence. Nat Genet. 2018;50(7):912–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kurki MI, Karjalainen J, Palta P, Sipilä TP, Kristiansson K, Donner KM, Reeve MP, Laivuori H, Aavikko M, Kaunisto MA, et al. FinnGen provides genetic insights from a well-phenotyped isolated population. Nature. 2023;613(7944):508–18.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schiavone S, Colaianna M, Curtis L. Impact of early life stress on the Pathogenesis of Mental disorders: relation to Brain oxidative stress. Curr Pharm Design. 2015;21(11):1404–12.

Article  CAS  Google Scholar 

Momany AM, Kamradt JM, Nikolas MA. A Meta-analysis of the Association between Birth Weight and attention deficit hyperactivity disorder. J Abnorm Child Psychol. 2018;46(7):1409–26.

Article  PubMed  PubMed Central  Google Scholar 

He R, Mo J, Zhu K, Luo Q, Liu X, Huang H, Sheng J. The early life course-related traits with three psychiatric disorders: a two-sample mendelian randomization study. Front Psychiatry 2023, 14.

Xu X, Zhuo L, Zhang L, Peng H, Lyu Y, Sun H, Zhai Y, Luo D, Wang X, Li X, et al. Dexmedetomidine alleviates host ADHD-like behaviors by reshaping the gut microbiota and reducing gut-brain inflammation. Psychiatry Res. 2023;323:115172.

Article  CAS  PubMed  Google Scholar 

Lips P, van Schoor NM. The effect of vitamin D on bone and osteoporosis. Best Pract Res Clin Endocrinol Metab. 2011;25(4):585–91.

Article  CAS  PubMed  Google Scholar 

Vannucci L, Masi L, Gronchi G, Fossi C, Carossino AM, Brandi ML. Calcium intake, bone mineral density, and fragility fractures: evidence from an Italian outpatient population. Archives Osteoporos 2017, 12(1).

Ceylan MN, Akdas S, Yazihan N. Is zinc an important Trace element on bone-related diseases and complications? A Meta-analysis and systematic review from serum level, Dietary Intake, and supplementation aspects. Biol Trace Elem Res. 2020;199(2):535–49.

Article  PubMed  Google Scholar 

van der Valk RJP, Kreiner-Møller E, Kooijman MN, Guxens M, Stergiakouli E, Sääf A, Bradfield JP, Geller F, Hayes MG, Cousminer DL, et al. A novel common variant in DCST2 is associated with length in early life and height in adulthood. Hum Mol Genet. 2015;24(4):1155–68.

Article  PubMed  Google Scholar 

Warrington NM, Beaumont RN, Horikoshi M, Day FR, Helgeland Ø, Laurin C, Bacelis J, Peng S, Hao K, Feenstra B, et al. Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. Nat Genet. 2019;51(5):804–14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Copenhaver GP, Vogelezang S, Bradfield JP, Ahluwalia TS, Curtin JA, Lakka TA, Grarup N, Scholz M, van der Most PJ, Monnereau C et al. Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits. PLoS Genet 2020, 16(10).

Elsworth B, Lyon M, Alexander T, Liu Y, Matthews P, Hallett J, Bates P, Palmer T, Haberland V, Smith GD et al. The MRC IEU OpenGWAS data infrastructure. 2020:2020.2008.2010.244293.

Yao C, Zhang Y, Lu P, Xiao B, Sun P, Tao J, Cheng Y, Kong L, Xu D, Fang M. Exploring the bidirectional relationship between pain and mental disorders

留言 (0)

沒有登入
gif