Waller AV, Owen R. Experiments on the section of the glossopharyngeal and hypoglossal nerves of the frog, and observations of the alterations produced thereby in the structure of their primitive fibres. Philos Trans R Soc Lond. 1850;140:423–9.

Google Scholar 

Griffin JW, Gold BG, Cork LC, Price DL, Lowndes HE. Idpn neuropathy in the cat: coexistence of proximal and distal axonal swellings. Neuropathol Appl Neurobiol. 1982;8:351–64.

Article  CAS  PubMed  Google Scholar 

Bouldin TW, Cavanagh JB. Organophosphorous neuropathy. I. A teased-fiber study of the spatio-temporal spread of axonal degeneraion. Am J Pathol. 1979;94:241–52.

CAS  PubMed  PubMed Central  Google Scholar 

Lunn ER, Perry VH, Brown MC, Rosen H, Gordon S. Absence of Wallerian degeneration does not hinder regeneration in peripheral nerve. Eur J Neurosci. 1989;1:27–33.

Article  CAS  PubMed  Google Scholar 

Conforti L, Tarlton A, Mack TGA, Mi W, Buckmaster EA, Wagner D, et al. A Ufd2/D4Cole1e chimeric protein and overexpression of Rbp7 in the slow Wallerian degeneration (WldS) mouse. PNAS. 2000;97:11377–82.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mack TG, Reiner M, Beirowski B, Mi W, Emanuelli M, Wagner D, et al. Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene. Nat Neurosci. 2001;4:1199–206.

Article  CAS  PubMed  Google Scholar 

Coleman MP, Conforti L, Buckmaster EA, Tarlton A, Ewing RM, Brown MC, et al. An 85-kb tandem triplication in the slow Wallerian degeneration (Wlds) mouse. PNAS. 1998;95:9985–90.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Perry VH, Brown MC, Lunn ER. Very slow retrograde and Wallerian degeneration in the CNS of C57BL/Ola mice. Eur J Neurosci. 1991;3:102–5.

Article  CAS  PubMed  Google Scholar 

Ferri A, Sanes JR, Coleman MP, Cunningham JM, Kato AC. Inhibiting axon degeneration and synapse loss attenuates apoptosis and disease progression in a mouse model of motoneuron disease. Curr Biol. 2003;13:669–73.

Article  CAS  PubMed  Google Scholar 

Wang MS, Wu Y, Culver DG, Glass JD. The gene for slow Wallerian degeneration (Wlds) is also protective against vincristine neuropathy. Neurobiol Dis. 2001;8:155–61.

Article  CAS  PubMed  Google Scholar 

Loreto A, Hill CS, Hewitt VL, Orsomando G, Angeletti C, Gilley J, et al. Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration. Neurobiol Dis. 2020;134:104678.

Article  CAS  PubMed  Google Scholar 

Cheng Y, Liu J, Luan Y, Liu Z, Lai H, Zhong W, et al. Sarm1 gene deficiency attenuates diabetic peripheral neuropathy in mice. Diabetes. 2019;68:2120–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu SS, Ren Y, Zhang M, Cao JQ, Yang Q, Li XY, et al. WldSprotects against peripheral neuropathy and retinopathy in an experimental model of diabetes in mice. Diabetologia. 2011;54:2440.

Article  CAS  PubMed  Google Scholar 

Conforti L, Gilley J, Coleman MP. Wallerian degeneration: an emerging axon death pathway linking injury and disease. Nat Rev Neurosci. 2014;15:394–409.

Article  CAS  PubMed  Google Scholar 

Coleman MP, Höke A. Programmed axon degeneration: from mouse to mechanism to medicine. Nat Rev Neurosci. 2020;21:183–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gilley J, Ribchester RR, Coleman MP. Sarm1 deletion, but not WldS, confers lifelong rescue in a mouse model of severe axonopathy. Cell Rep. 2017;21:10–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gilley J, Orsomando G, Nascimento-Ferreira I, Coleman MP. Absence of SARM1 rescues development and survival of NMNAT2-deficient axons. Cell Rep. 2015;10:1974–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Loreto A, Angeletti C, Gu W, Osborne A, Nieuwenhuis B, Gilley J, et al. Neurotoxin-mediated ­­potent activation of the axon degeneration regulator SARM1. eLife. 2021;10:e72823.

Article  CAS  PubMed  PubMed Central  Google Scholar 

LeWitt PA. The neurotoxicity of the rat poison vacor. N Engl J Med. 1980;302:73–7.

Article  CAS  PubMed  Google Scholar 

Huppke P, Wegener E, Gilley J, Angeletti C, Kurth I, Drenth JPH, et al. Homozygous NMNAT2 mutation in sisters with polyneuropathy and erythromelalgia. Exp Neurol. 2019;320:112958.

Article  CAS  PubMed  Google Scholar 

Lukacs M, Gilley J, Zhu Y, Orsomando G, Angeletti C, Liu J, et al. Severe biallelic loss-of-function mutations in nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) in two fetuses with fetal akinesia deformation sequence. Exp Neurol. 2019;320:112961.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dingwall CB, Strickland A, Yum SW, Yim AK, Zhu J, Wang PL, et al. Macrophage depletion blocks congenital SARM1-dependent neuropathy. J Clin Invest. 2022;132:e159800.

Howell GR, Libby RT, Jakobs TC, Smith RS, Phalan FC, Barter JW, et al. Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma. J Cell Biol. 2007;179:1523–37.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Beirowski B, Babetto E, Coleman MP, Martin KR. The WldS gene delays axonal but not somatic degeneration in a rat glaucoma model. Eur J Neurosci. 2008;28:1166–79.

Article  PubMed  Google Scholar 

Williams PA, Harder JM, Foxworth NE, Cochran KE, Philip VM, Porciatti V, et al. Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice. Science. 2017;355:756–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Williams PA, Harder JM, Foxworth NE, Cardozo BH, Cochran KE, John SWM. Nicotinamide and WLDS act together to prevent neurodegeneration in glaucoma. Front Neurosci. 2017;11:232.

Article  PubMed  PubMed Central  Google Scholar 

Fang F, Zhuang P, Feng X, Liu P, Liu D, Huang H, et al. NMNAT2 is downregulated in glaucomatous RGCs, and RGC-specific gene therapy rescues neurodegeneration and visual function. Mol Ther. 2022;30:1421–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu Y, Zhang L, Sasaki Y, Milbrandt J, Gidday JM. Protection of mouse retinal ganglion cell axons and soma from glaucomatous and ischemic injury by cytoplasmic overexpression of Nmnat1. Invest Ophthalmol Vis Sci. 2013;54:25–36.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu P, Chen W, Jiang H, Huang H, Liu L, Fang F, et al. Differential effects of SARM1 inhibition in traumatic glaucoma and EAE optic neuropathies. Mol Ther Nucleic Acids. 2023;32:13–27.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fernandes KA, Mitchell KL, Patel A, Marola OJ, Shrager P, Zack DJ, et al. Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury. Exp Eye Res. 2018;171:54–61.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ko KW, Milbrandt J, DiAntonio A. SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration. J Cell Biol. 2020;219:e201912047.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Finnegan LK, Chadderton N, Kenna PF, Palfi A, Carty M, Bowie AG, et al. SARM1 ablation is protective and preserves spatial vision in an in vivo mouse model of retinal ganglion cell degeneration. Int J Mol Sci. 2022;23:1606.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Massoll C, Mando W, Chintala SK. Excitotoxicity upregulates SARM1 protein expression and promotes wallerian-like degeneration of retinal ganglion cells and their axons. Investig Ophthalmol Vis Sci. 2013;54:2771–80.

Article  CAS  Google Scholar 

Ozaki E, Gibbons L, Neto NG, Kenna P, Carty M, Humphries M, et al. SARM1 deficiency promotes rod and cone photoreceptor cell survival in a model of retinal degeneration. Life Sci Alliance. 2020;3:e201900618. https://www.life-science-alliance.org/content/3/5/e201900618.

Article  PubMed  PubMed Central  Google Scholar 

Sasaki Y, Kakita H, Kubota S, Sene A, Lee TJ, Ban N. et al. SARM1 depletion rescues NMNAT1-dependent photoreceptor cell death and retinal degeneration. eLife. 2020;9:e62027.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gibbons L, Ozaki E, Greene C, Trappe A,