Adeolu M, Alnajar S, Naushad S, Gupta RS (2016) Genome-based phylogeny and taxonomy of the ‘Enterobacteriales’: proposal for enterobacterales ord. nov. divided into the families Enterobacteriaceae, Erwiniaceae fam. nov., Pectobacteriaceae fam. nov., Yersiniaceae fam. nov., Hafniaceae fam. Nov., Morgane. Int J Syst Evol Microbiol 66:5575–5599. https://doi.org/10.1099/ijsem.0.001485

Article  CAS  PubMed  Google Scholar 

Martínez J, Martínez L, Rosenblueth M, Silva J, Martínez-Romero E (2004) How are gene sequence analyses modifying bacterial taxonomy? case Klebsiella Int Microbiol 7:261–268. https://doi.org/10.2436/im.v7i4.9481

Article  PubMed  Google Scholar 

Park EA, Kim YT, Cho JH, Ryu S, Lee JH (2017) Characterization and genome analysis of novel bacteriophages infecting the opportunistic human pathogens Klebsiella oxytoca and K. pneumoniae. Arch Virol 162:1129–1139. https://doi.org/10.1007/s00705-016-3202-3

Article  CAS  PubMed  Google Scholar 

Cheng J, Zhou M, Nobrega DB et al (2021) Genetic diversity and molecular epidemiology of outbreaks of Klebsiella pneumoniae mastitis on two large Chinese dairy farms. J Dairy Sci 104:762–775. https://doi.org/10.3168/jds.2020-19325

Article  CAS  PubMed  Google Scholar 

Tzouvelekis LS, Miriagou V, Kotsakis SD et al (2013) KPC-producing, multidrug-resistant Klebsiella pneumoniae sequence Type 258 as a typical opportunistic pathogen. Antimicrob Agents Chemother 57:5144–5146. https://doi.org/10.1128/AAC.01052-13

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heinz E, Brindle R, Morgan-McCalla A, Peters K, Thomson NR (2019) Caribbean multi-centre study of Klebsiella pneumoniae: whole-genome sequencing, antimicrobial resistance and virulence factors. Microb Genom. https://doi.org/10.1099/mgen.0.000266

Article  PubMed  PubMed Central  Google Scholar 

Pomakova DK, Hsiao CB, Beanan JM et al (2012) Clinical and phenotypic differences between classic and hypervirulent Klebsiella pneumoniae: an emerging and under-recognized pathogenic variant. Eur J Clin Microbiol Infect Dis 31:981–989. https://doi.org/10.1007/s10096-011-1396-6

Article  CAS  PubMed  Google Scholar 

Sato S, Aoyama T, Uejima Y et al (2019) Pyogenic liver abscess due to hypervirulent Klebsiella pneumoniae in a 14-year-old boy. J Infect Chemother 25:137–140. https://doi.org/10.1016/j.jiac.2018.07.006

Article  PubMed  Google Scholar 

Paczosa MK, Mecsas J (2016) Klebsiella pneumoniae: going on the offense with a strong defense. Microbiol Mol Biol Rev 80:629–661. https://doi.org/10.1128/mmbr.00078-15

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsay RW, Siu LK, Fung CP, Chang FY (2002) Characteristics of bacteremia between community-acquired and nosocomial Klebsiella pneumoniae infection. Arch Intern Med 162:1021. https://doi.org/10.1001/archinte.162.9.1021

Article  PubMed  Google Scholar 

Gonzalez-Ferrer S, Peñaloza HF, Budnick JA et al (2021) Finding order in the chaos: outstanding questions in Klebsiella pneumoniae pathogenesis. Infect Immun 89:e00693-e720. https://doi.org/10.1128/IAI.00693-20

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu C, Guo J (2019) Hypervirulent Klebsiella pneumoniae (hypermucoviscous and aerobactin positive) infection over 6 years in the elderly in China: antimicrobial resistance patterns, molecular epidemiology and risk factor. Ann Clin Microbiol Antimicrob. https://doi.org/10.1186/s12941-018-0302-9

Article  PubMed  PubMed Central  Google Scholar 

Zhang Y, Zhao C, Wang Q et al (2016) High prevalence of hypervirulent Klebsiella pneumoniae infection in China: geographic distribution, clinical characteristics, and antimicrobial resistance. Antimicrob Agents Chemother 60:6115–6120. https://doi.org/10.1128/AAC.01127-16

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shon AS, Bajwa RPS, Russo TA (2013) Hypervirulent (hypermucoviscous) Klebsiella pneumoniae: a new and dangerous breed. Virulence 4:107–118. https://doi.org/10.4161/viru.22718

Article  PubMed  PubMed Central  Google Scholar 

Rafat C, Messika J, Barnaud G et al (2018) Hypervirulent Klebsiella pneumoniae, a 5-year study in a French ICU. J Med Microbiol 67:1083–1089. https://doi.org/10.1099/jmm.0.000788

Article  CAS  PubMed  Google Scholar 

Yamamoto H, Iijima A, Kawamura K, Matsuzawa Y, Suzuki M, Arakawa Y (2020) Fatal fulminant community-acquired pneumonia caused by hypervirulent Klebsiella pneumoniae K2-ST86. Medicine 99:e20360. https://doi.org/10.1097/MD.0000000000020360

Article  PubMed  PubMed Central  Google Scholar 

Coutinho RL, Visconde MF, Descio FJ et al (2014) Community-acquired invasive liver abscess syndrome caused by a K1 serotype Klebsiella pneumoniae isolate in Brazil: a case report of hypervirulent ST23. Mem Inst Oswaldo Cruz 109:970–971. https://doi.org/10.1590/0074-0276140196

Article  PubMed  PubMed Central  Google Scholar 

Yu WL, Ko WC, Cheng KC et al (2006) Association between rmpA and magA genes and clinical syndromes caused by Klebsiella pneumoniae in Taiwan. Clin Infect Dis 42:1351–1358. https://doi.org/10.1086/503420

Article  CAS  PubMed  Google Scholar 

Oikonomou KG, Aye M (2017) Klebsiella pneumoniae Liver Abscess: a case series of six Asian patients. Am J Case Rep 18:1028–1033. https://doi.org/10.12659/AJCR.905191

Article  PubMed  PubMed Central  Google Scholar 

Maruki T, Taniyama D, Tsuchiya Y, Adachi T (2020) Breakthrough and persistent bacteremia due to serotype K1 Klebsiella pneumoniae in an immunocompetent patient. IDCases 21:e00893. https://doi.org/10.1016/j.idcr.2020.e00893

Article  PubMed  PubMed Central  Google Scholar 

Shaidullina E, Shelenkov A, Yanushevich Y et al (2020) Antimicrobial resistance and genomic characterization of OXA-48- and CTX-M-15-Co-producing hypervirulent Klebsiella pneumoniae ST23 recovered from nosocomial outbreak. Antibiotics 9:862. https://doi.org/10.3390/antibiotics9120862

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gu D, Dong N, Zheng Z et al (2018) A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study. Lancet Infect Dis 18:37–46. https://doi.org/10.1016/S1473-3099(17)30489-9

Article  PubMed  Google Scholar 

Yao H, Qin S, Chen S, Shen J, Du XD (2018) Emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae. Lancet Infect Dis 18:25. https://doi.org/10.1016/S1473-3099(17)30628-X

Article  PubMed  Google Scholar 

Shankar C, Jacob JJ, Vasudevan K et al (2020) Emergence of multidrug resistant hypervirulent ST23 Klebsiella pneumoniae: multidrug resistant plasmid acquisition drives evolution. Front Cell Infect Microbiol. https://doi.org/10.3389/fcimb.2020.575289

Article  PubMed  PubMed Central  Google Scholar 

Chen Y, Marimuthu K, Teo J et al (2020) Acquisition of plasmid with carbapenem-resistance gene bla KPC2 in hypervirulent Klebsiella pneumoniae. Singapore Emerg Infect Dis 26:549–559. https://doi.org/10.3201/eid2603.191230

Article  CAS  PubMed  Google Scholar 

Feldman MF, Mayer Bridwell AE, Scott NE et al (2019) A promising bioconjugate vaccine against hypervirulent Klebsiella pneumoniae. Proc Natl Acad Sci 116:18655–18663. https://doi.org/10.1073/pnas.1907833116

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cryz SJ, Furer E, Germanier R (1985) Safety and immunogenicity of Klebsiella pneumoniae K1 capsular polysaccharide vaccine in humans. J Infect Dis 151:665–671. https://doi.org/10.1093/infdis/151.4.665

Article  PubMed  Google Scholar 

Edelman R, Talor DN, Wasserman SS et al (1994) Phase 1 trial of a 24-valent Klebsiella capsular polysaccharide vaccine and an eight-valent Pseudomonas O-polysaccharide conjugate vaccine administered simultaneously. Vaccine 12:1288–1294. https://doi.org/10.1016/S0264-410X(94)80054-4

Article  CAS  PubMed  Google Scholar 

Ravinder M, Liao K-S, Cheng Y-Y et al (2020) A synthetic carbohydrate-protein conjugate vaccine candidate against Klebsiella pneumoniae serotype K2. J Org Chem 85:15964–15997. https://doi.org/10.1021/acs.joc.0c01404

Article  CAS  PubMed  Google Scholar 

Whitfield C (2006) Biosynthesis and assembly of capsular polysaccharides in Escherichia coli. Annu Rev Biochem 75:39–68. https://doi.org/10.1146/annurev.biochem.75.103004.142545

Article  CAS  PubMed  Google Scholar 

Wyres KL, Wick RR, Gorrie C et al (2016) Identification of Klebsiella capsule synthesis loci from whole genome data. Microb Genom 2:e000102. https://doi.org/10.1099/mgen.0.000102

Article  PubMed  PubMed Central  Google Scholar 

Liao CH, Huang YT, Chang CY, Hsu HS, Hsueh PR (2014) Capsular serotypes and multilocus sequence types of bacteremic Klebsiella pneumoniae isolates associated with different types of infections. Eur J Clin Microbiol Infect Dis 33:365–369. https://doi.org/10.1007/s10096-013-1964-z

Article  CAS  PubMed  Google Scholar 

Struve C, Roe CC, Stegger M et al (2015) Mapping the evolution of hypervirulent Klebsiella pneumoniae. MBio 6:e00630-e715. https://doi.org/10.1128/mBi