Developing injectable hydrogel dressings with multifunctional properties, including antibacterial, antioxidant ability, and good mechanical property to treat infected full-thickness skin wound is of particular importance in clinical application. Incorporation of metal ions, such as Zn2+, Ca2+, and Fe2+ confer the hydrogels with unique properties, including conductivity, bioactivity, and tunability. In this study, a multifunctional near infrared (NIR) active hydrogel, named Alg-HA-Zn-PDA, was fabricated via the incorporation of polydopamine (PDA) nanoparticles into hyaluronic acid (HA) and alginate (Alg) crosslinked by Zn2+. This hydrogel exhibited high porosity, good mechanical property, and high water content which is essential requirement in the adsorption of exudates during the healing process. PDA endowed the hydrogels with antioxidant activity, hemostatic ability, and made the hydrogels NIR active. Zn2+ could contribute in antibacterial and healing effects of the hydrogels. The antibacterial activity of Alg-HA-Zn-PDA, with and without NIR irradiation against Escherichia coli (E.coli) and Staphylococcus aureus (S. aureus), showed that the NIR light irradiation could result in heat generation and destroyed the bacteria. Furthermore, in vivo treatment in a S. aureus-infected full-thickness skin defect model demonstrated that the Alg-HA-Zn-PDA hydrogel possess excellent wound closure capacity of the hydrogels in the presence of NIR irradiation. In summary, the antibacterial, hemostatic, and antioxidant hydrogels is an excellent candidate as wound dressing for the repairing of full-thickness skin defects.