Chase MH. Motor control during sleep and wakefulness: clarifying controversies and resolving paradoxes. Sleep Med Rev. 2013;17:299–312.
Besedovsky L, Lange T, Haack M. The sleep-immune crosstalk in health and disease. Physiol Rev. 2019;99:1325–80.
Article PubMed PubMed Central Google Scholar
Dupont D, Lin J-S, Peyron F, Akaoka H, Wallon M. Chronic Toxoplasma gondii infection and sleep-wake alterations in mice. CNS Neurosci Ther. 2021;27:895–907.
Article CAS PubMed PubMed Central Google Scholar
Ragnoli B, Pochetti P, Pignatti P, Barbieri M, Mondini L, Ruggero L, et al. Sleep deprivation, immune suppression and SARS-CoV-2 infection. Int J Environ Res Public Health. 2022; 19.
Guerau-de-Arellano M, Piedra-Quintero ZL, Tsichlis PN. Akt isoforms in the immune system. Front Immunol. 2022;13: 990874.
Article CAS PubMed PubMed Central Google Scholar
Liu H, Stepicheva NA, Ghosh S, Shang P, Chowdhury O, Daley RA, et al. Reducing Akt2 in retinal pigment epithelial cells causes a compensatory increase in Akt1 and attenuates diabetic retinopathy. Nat Commun. 2022;13:6045.
Article CAS PubMed PubMed Central Google Scholar
Di Lorenzo A, Fernandez-Hernando C, Cirino G, Sessa WC. Akt1 is critical for acute inflammation and histamine-mediated vascular leakage. Proc Natl Acad Sci USA. 2009;106:14552–7.
Article PubMed PubMed Central Google Scholar
Babaev VR, Hebron KE, Wiese CB, Toth CL, Ding L, Zhang Y, et al. Macrophage deficiency of Akt2 reduces atherosclerosis in Ldlr null mice. J Lipid Res. 2014;55:2296–308.
Article CAS PubMed PubMed Central Google Scholar
Nie Y, Sun L, Wu Y, Yang Y, Wang J, He H, et al. AKT2 regulates pulmonary inflammation and fibrosis via modulating macrophage activation. J Immunol. 2017;198:4470–80.
Article CAS PubMed Google Scholar
Nie Y, Wang Z, Chai G, Xiong Y, Li B, Zhang H, et al. Dehydrocostus Lactone Suppresses LPS-induced Acute Lung Injury and Macrophage Activation through NF-κB Signaling Pathway Mediated by p38 MAPK and Akt. Molecules. 2019; 24.
Dummler B, Tschopp O, Hynx D, Yang ZZ, Dirnhofer S, Hemmings BA. Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies. Mol Cell Biol. 2006;26:8042–51.
Article CAS PubMed PubMed Central Google Scholar
Palumbo S, Paterson C, Yang F, Hood VL, Law AJ. PKBbeta/AKT2 deficiency impacts brain mTOR signaling, prefrontal cortical physiology, hippocampal plasticity and select murine behaviors. Mol Psychiatry. 2021;26:411–28.
Article CAS PubMed Google Scholar
Chang CY, Chen YW, Wang TW, Lai WS. Akting up in the GABA hypothesis of schizophrenia: Akt1 deficiency modulates GABAergic functions and hippocampus-dependent functions. Sci Rep. 2016;6:33095.
Article CAS PubMed PubMed Central Google Scholar
Islam MT, Rumpf F, Tsuno Y, Kodani S, Sakurai T, Matsui A, et al. Vasopressin neurons in the paraventricular hypothalamus promote wakefulness via lateral hypothalamic orexin neurons. Curr Biol. 2022.
Li S-B, Damonte VM, Chen C, Wang GX, Kebschull JM, Yamaguchi H, et al. Hyperexcitable arousal circuits drive sleep instability during aging. Science. 2022;375: eabh3021.
Adamantidis AR, Zhang F, Aravanis AM, Deisseroth K, de Lecea L. Neural substrates of awakening probed with optogenetic control of hypocretin neurons. Nature. 2007;450:420–4.
Article CAS PubMed PubMed Central Google Scholar
Gaykema RP, Goehler LE. Lipopolysaccharide challenge-induced suppression of Fos in hypothalamic orexin neurons: their potential role in sickness behavior. Brain Behav Immun. 2009;23:926–30.
Article CAS PubMed PubMed Central Google Scholar
Tanaka S, Toyoda H, Honda Y, Seki Y, Sakurai T, Honda K, et al. Hypocretin/orexin prevents recovery from sickness. Biomedical reports. 2015;3:648–50.
Article CAS PubMed PubMed Central Google Scholar
Zhao P, Shao YF, Zhang M, Fan K, Kong XP, Wang R, et al. Neuropeptide S promotes wakefulness through activation of the posterior hypothalamic histaminergic and orexinergic neurons. Neuroscience. 2012;207:218–26.
Article CAS PubMed Google Scholar
Maloney KJ, Cape EG, Gotman J, Jones BE. High-frequency gamma electroencephalogram activity in association with sleep-wake states and spontaneous behaviors in the rat. Neuroscience. 1997;76:541–55.
Article CAS PubMed Google Scholar
Alexaki VI, Fodelianaki G, Neuwirth A, Mund C, Kourgiantaki A, Ieronimaki E, et al. DHEA inhibits acute microglia-mediated inflammation through activation of the TrkA-Akt1/2-CREB-Jmjd3 pathway. Mol Psychiatry. 2018;23:1410–20.
Article CAS PubMed Google Scholar
Appelbaum L, Wang G, Yokogawa T, Skariah GM, Smith SJ, Mourrain P, et al. Circadian and homeostatic regulation of structural synaptic plasticity in hypocretin neurons. Neuron. 2010;68:87–98.
Article CAS PubMed PubMed Central Google Scholar
De Luca R, Nardone S, Grace KP, Venner A, Cristofolini M, Bandaru SS, et al. Orexin neurons inhibit sleep to promote arousal. Nat Commun. 2022;13:4163.
Article PubMed PubMed Central Google Scholar
Nixon JP, Mavanji V, Butterick TA, Billington CJ, Kotz CM, Teske JA. Sleep disorders, obesity, and aging: the role of orexin. Ageing Res Rev. 2015;20:63–73.
Article CAS PubMed Google Scholar
Szentirmai E, Massie AR, Kapas L. Lipoteichoic acid, a cell wall component of Gram-positive bacteria, induces sleep and fever and suppresses feeding. Brain Behav Immun. 2021;92:184–92.
Article CAS PubMed Google Scholar
Szentirmai É, Krueger JM. Sickness behaviour after lipopolysaccharide treatment in ghrelin deficient mice. Brain Behav Immun. 2014;36:200–6.
Article CAS PubMed Google Scholar
Zhang B-J, Shao S-R, Aritake K, Takeuchi A, Urade Y, Huang Z-L, et al. Interleukin-1β induces sleep independent of prostaglandin D in rats and mice. Neuroscience. 2017;340:258–67.
Article CAS PubMed Google Scholar
Hogan D, Morrow JD, Smith EM, Opp MR. Interleukin-6 alters sleep of rats. J Neuroimmunol. 2003;137:59–66.
Article CAS PubMed Google Scholar
Beard RS, Hoettels BA, Meegan JE, Wertz TS, Cha BJ, Yang X, et al. AKT2 maintains brain endothelial claudin-5 expression and selective activation of IR/AKT2/FOXO1-signaling reverses barrier dysfunction. J Cereb Blood Flow Metab. 2020;40:374–91.
Article CAS PubMed Google Scholar
Igarashi S, Nozu T, Ishioh M, Kumei S, Saito T, Toki Y, et al. Centrally administered orexin prevents lipopolysaccharide and colchicine induced lethality via the vagal cholinergic pathway in a sepsis model in rats. Biochem Pharmacol. 2020;182: 114262.
Article CAS PubMed Google Scholar
Arranz A, Doxaki C, Vergadi E, Martinez de la Torre Y, Vaporidi K, Lagoudaki ED, et al. Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization. Proc Natl Acad Sci USA. 2012;109:9517–22.
留言 (0)