January CT, Wann LS, Calkins H, Chen LY, Cigarroa JE, Cleveland JC, Ellinor PT, Ezekowitz MD, Field ME, Furie KL, Heidenreich PA, Murray KT, Shea JB, Tracy CM, Yancy CW. 2019 AHA/ACC/HRS focused update of the 2014 aha/acc/hrs guideline for the management of patients with atrial fibrillation: a report of the american college of cardiology/american heart association task force on clinical practice guidelines and the heart rhythm society in collaboration with the society of thoracic surgeons. Circulation. 2019;140(2):e125–51.

Article  PubMed  Google Scholar 

Hindricks G, Potpara T, Dagres N, Arbelo E, Bax JJ, Blomström-Lundqvist C, Boriani G, Castella M, Dan G-A, Dilaveris PE, Fauchier L, Filippatos G, Kalman JM, La Meir M, Lane DA, Lebeau J-P, Lettino M, Lip GYH, Pinto FJ, Thomas GN, Valgimigli M, Van Gelder IC, Van Putte BP, Watkins CL. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Eur Heart J. 2021;42(5):373–498.

Article  PubMed  Google Scholar 

Benjamin EJ, Muntner P, Alonso A, Bittencourt MS, Callaway CW, Carson AP, Chamberlain AM, Chang AR, Cheng S, Das SR, Delling FN, Djousse L, Elkind MSV, Ferguson JF, Fornage M, Jordan LC, Khan SS, Kissela BM, Knutson KL, Kwan TW, Lackland DT, Lewis TT, Lichtman JH, Longenecker CT, Loop MS, Lutsey PL, Martin SS, Matsushita K, Moran AE, Mussolino ME, O'Flaherty M, Pandey A, Perak AM, Rosamond WD, Roth GA, Sampson UKA, Satou GM, Schroeder EB, Shah SH, Spartano NL, Stokes A, Tirschwell DL, Tsao CW, Turakhia MP, VanWagner LB, Wilkins JT, Wong SS, Virani SS, American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee. Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association. Circulation. 2019;139(10):e56–528. https://doi.org/10.1161/CIR.0000000000000659.

Glikson M, Wolff R, Hindricks G, Mandrola J, Camm AJ, Lip GYH, Fauchier L, Betts TR, Lewalter T, Saw J, Tzikas A, Sternik L, Nietlispach F, Berti S, Sievert H, Bertog S, Meier B. EHRA/EAPCI expert consensus statement on catheter-based left atrial appendage occlusion - an update. Europace. 2020;22(2):184.

Article  PubMed  Google Scholar 

Lip GYH, Banerjee A, Boriani G, Chiang CE, Fargo R, Freedman B, Lane DA, Ruff CT, Turakhia M, Werring D, Patel S, Moores L. Antithrombotic Therapy for Atrial Fibrillation: CHEST Guideline and Expert Panel Report. Chest. 2018;154(5):1121–201.

Article  PubMed  Google Scholar 

Zhan Y, Joza J, AlRawahi M, Barbosa RS, Samuel M, Bernier M, Huynh T, Thanassoulis G, Essebag V. Assessment and Management of the Left Atrial Appendage Thrombus in Patients With Nonvalvular Atrial Fibrillation. Can J Cardiol. 2018;34(3):252–61.

Article  PubMed  Google Scholar 

Bajwa RJ, Kovell L, Resar JR, Arbab-Zadeh A, Mandal K, Calkins H, Berger RD. Left atrial appendage occlusion for stroke prevention in patients with atrial fibrillation. Clin Cardiol. 2017;40(10):825–31.

Article  PubMed  PubMed Central  Google Scholar 

Reddy VY, Sievert H, Halperin J, Doshi SK, Buchbinder M, Neuzil P, Huber K, Whisenant B, Kar S, Swarup V, Gordon N, Holmes D. Percutaneous left atrial appendage closure vs warfarin for atrial fibrillation: a randomized clinical trial. JAMA. 2014;312(19):1988–98.

Article  PubMed  Google Scholar 

Holmes DR, Reddy VY, Turi ZG, Doshi SK, Sievert H, Buchbinder M, Mullin CM, Sick P. Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial. Lancet. 2009;374(9689):534–42.

Article  CAS  PubMed  Google Scholar 

Holmes DR, Kar S, Price MJ, Whisenant B, Sievert H, Doshi SK, Huber K, Reddy VY. Prospective randomized evaluation of the Watchman Left Atrial Appendage Closure device in patients with atrial fibrillation versus long-term warfarin therapy: the PREVAIL trial. J Am Coll Cardiol. 2014;64(1):1–12.

Article  PubMed  Google Scholar 

Osmancik P, Herman D, Neuzil P, Hala P, Taborsky M, Kala P, Poloczek M, Stasek J, Haman L, Branny M, Chovancik J, Cervinka P, Holy J, Kovarnik T, Zemanek D, Havranek S, Vancura V, Opatrny J, Peichl P, Tousek P, Lekesova V, Jarkovsky J, Novackova M, Benesova K, Widimsky P, Reddy VY. Left Atrial Appendage Closure Versus Direct Oral Anticoagulants in High-Risk Patients With Atrial Fibrillation. J Am Coll Cardiol. 2020;75(25):3122–35.

Article  CAS  PubMed  Google Scholar 

Bordignon S, Bologna F, Chen S, Konstantinou A, Tsianakas N, Tohoku S, Trolese L, Chun KJ, Schmidt B. Percutaneous left atrial appendage closure in the presence of thrombus: A feasibility report. J Cardiovasc Electrophysiol. 2019;30(12):2858–63.

Article  PubMed  Google Scholar 

Jin L-S, Ke J-Y, Lin Y-N, Li L, Fu J-Y, Chen Y-L, Qiu Y-X, Li X-W, Pan Y-Q, Li Y-C. Percutaneous left atrial appendage closure using the LAmbre device in patients with atrial fibrillation and left atrial appendage thrombus. Front Cardiovasc Med. 2022;9:1071119.

Article  PubMed  PubMed Central  Google Scholar 

Sharma SP, Cheng J, Turagam MK, Gopinathannair R, Horton R, Lam YY, Tarantini G, DAmico G, Freixa Rofastes X, Lange M, Natale A, Lakkireddy DR. Feasibility of left atrial appendage occlusion in left atrial appendage thrombus a systematic review. JACC Clin Electrophysiol. 2020;6(4):414–24.

Article  PubMed  Google Scholar 

Meier B, Blaauw Y, Khattab AA, Lewalter T, Sievert H, Tondo C, Glikson M. EHRA/EAPCI expert consensus statement on catheter-based left atrial appendage occlusion. Europace. 2014;16(10):1397–416.

Article  PubMed  Google Scholar 

Wintgens LIS, Maarse M, Swaans MJ, Rensing BJWM, Van Dijk VF, Boersma LVA. The WATCHMAN left atrial appendage closure device for patients with atrial fibrillation: current status and future perspectives. Expert Rev Med Devices. 2020;17(7):615–26.

Article  CAS  PubMed  Google Scholar 

Messas N, Ibrahim R. The Amplatzer Amulet Device: Technical Considerations and Procedural Approach. Interv Cardiol Clin. 2018;7(2):213–8.

PubMed  Google Scholar 

Schnupp S, Ajmi I, Brachmann J, Mahnkopf C. Lifetech LAmbre: a new promising and novel device in the interventional stroke prevention. Future Cardiol. 2019;15(6):405–10.

Article  CAS  PubMed  Google Scholar 

Marroquin L, Tirado-Conte G, Pracoń R, Streb W, Gutierrez H, Boccuzzi G, Arzamendi-Aizpurua D, Cruz-González I, Ruiz-Nodar JM, Kim JS, Freixa X, Lopez-Minguez JR, De Backer O, Ruiz-Salmeron R, Dominguez A, McInerney A, Peral V, Estevez-Loureiro R, Fernandez-Nofrerias E, Freitas-Ferraz AB, Saia F, Huczek Z, Gheorghe L, Salinas P, Demkow M, Delgado-Arana JR. Heart. 2022;108(14):1098–106.

Article  PubMed  Google Scholar 

Beneduce A, Ancona F, Marzi A, Radinovic A, D’Angelo G, Agricola E, Della Bella P, Mazzone P. Percutaneous treatment of persistent left atrial appendage thrombus using watchman FLX no-touch implantation technique and cerebral protection system. JACC Clin Electrophysiol. 2019;5(10):1231–2.

Article  PubMed  Google Scholar 

Lange M, Bültel H, Weglage H, Löffeld P, Wichter T. Closure of Left Atrial Appendage With Persistent Distal Thrombus using an Amplatzer Amulet Occluder. J Invasive Cardiol. 2016;28(9):E75–6.

PubMed  Google Scholar 

Saccà S, Ferro J, Umemoto T, Turri R, Penzo C, Pacchioni A. A New Strategy for Transcatheter Left Atrial Appendage Closure With Cerebral Embolic Protection in Patient With Left Auricular Thrombosis and Total Contraindication to Long-Term Anticoagulation. J Invasive Cardiol. 2017;29(3):E37–8.

PubMed  Google Scholar 

Jalal Z, Iriart X, Dinet M-L, Selly J-B, Tafer N, Renou P, Sibon I, Thambo J-B. Extending percutaneous left atrial appendage closure indications using the AMPLATZER™ Cardiac Plug device in patients with persistent left atrial appendage thrombus: The thrombus trapping technique. Arch Cardiovasc Dis. 2016;109(12):659–66.

Article  PubMed  Google Scholar 

Lee O-H, Kim J-S, Pak H-N, Hong G-R, Shim CY, Uhm J-S, Cho I-J, Joung B, Yu C-W, Lee H-J, Kang W-C, Shin E-S, Choi R-K, Lim D-S, Jang Y. Feasibility of Left Atrial Appendage Occlusion for Left Atrial Appendage Thrombus in Patients With Persistent Atrial Fibrillation. Am J Cardiol. 2018;121(12):1534–9.

Article  PubMed  Google Scholar 

Popescu SȘ, Heeger C-H, Keelani A, Tilz RR. Percutaneous Left Atrial Appendage Closure with the LAmbre Device Protected by a Cerebral Protection System in a 76-Year-Old Man with Persistent Left Atrial Appendage Thrombus. Am J Case Rep. 2022;23:e937063.

Article  PubMed  PubMed Central  Google Scholar 

Tan BEX, Depta JP. Transcatheter cerebral embolic protection during WATCHMAN procedure in two patients with persistent left atrial appendage thrombus: Case report with review of the literature. Catheter Cardiovasc Interv. 2021;97(2):365–8.

Article  PubMed  Google Scholar 

Tsai C-F, Huang P-S, Chiu F-C, Chen J-J, Chang S-N, Hsu J-C, Chua S-K, Cheng H-L, Wang Y-C, Hwang J-J, Tsai C-T. Bailout left atrial appendage occluder for pulmonary vein isolation and electrical cardioversion in patients with atrial fibrillation and left atrial appendage thrombus: a pilot study. Clin Res Cardiol. 2023;112(6):772–83.

Article  CAS  PubMed  Google Scholar 

Bellmann B, Rillig A, Leistner DM, Kasner M, Skurk C, Landmesser U, Park J-W. Left atrial appendage closure in a patient with left atrial appendage thrombus using a novel fish ball technique. Int J Cardiol. 2017;234:146–9.

Article  PubMed  Google Scholar 

Aytemir K, Aminian A, Asil S, Canpolat U, Kaya EB, Şahiner L, Evranos B, Yorgun H, Özer N. First case of percutaneous left atrial appendage closure by amulet™ device in a patient with left atrial appendage thrombus. Int J Cardiol. 2016;223:28–30.

Article  PubMed  Google Scholar 

Dugo D, Bordignon S, Konstantinou A, Perrotta L, Fürnkranz A, Chun JKR, Schmidt B. Locked Away: Percutaneous Closure of a Malignant Left Atrial Appendage to Constrain an Unresolvable Thrombus. Circ Arrhythm Electrophysiol. 2016;9(8):e004127.

Article  PubMed  Google Scholar 

Lee O-H, Uhm J-S, Kim J-S, Cho I-J, Hong G-R, Pak H-N, Jang Y. Percutaneous isolation of left atrial appendage thrombus. J Cardiol Cases. 2017;16(3):67–9.

Article  PubMed  PubMed Central  Google Scholar 

De Roeck F, Scott B, Verheye S, Vermeersch P. Percutaneous left atrial appendage occlusion in a lamin A/C gene mutation related cardiomyopathy patient with persistent left atrial appendage thrombus: a case report. Acta Cardiol. 2019;74(2):182–3.

Article  PubMed  Google Scholar 

Chang D, Kapur S, Romero J, Koplan BA, Tadros TM. CE-454611–3 High risk left atrial appendage closure in patients with a persistent left atrial appendage thrombus. Heart Rhythm. 2023;20(5):S9–10.

Article  Google Scholar 

Mohandes M, Pernigotti A, Morr CI, Bardají A. Percutaneous Left Atrial Appendage Closure in the Presence of Thrombus Using LAmbre Device and Cerebral Protection System. Korean Circ J. 2020;50(3):281–3.

Article  PubMed  PubMed Central  Google Scholar 

Kaczmarek K, Cygankiewicz I, Streb W, Plaksej R, Jakubowski P, Kalarus Z, Ptaszynski P, Wranicz JK, Babicz-Sadowska A, Markiewicz A, Grygier M. Percutaneous Occlusion of the Left Atrial Appendage with Thrombus Irresponsive to Antithrombotic Therapy. J Clin Med. 2021;10(4):726. https://doi.org/10.3390/jcm10040726.

Article  CAS