M.E. Rinella, J.V. Lazarus, V. Ratziu, S.M. Francque, A.J. Sanyal, F. Kanwal et al. A multi-society Delphi consensus statement on new fatty liver disease nomenclature. J. Hepatol. 0, 45 (2023)

Google Scholar 

E.L. Anderson, L.D. Howe, H.E. Jones, J.P.T. Higgins, D.A. Lawlor, A. Fraser, The prevalence of non-alcoholic fatty liver disease in children and adolescents: a systematic review and meta-analysis. PLoS One 10, e0140908 (2015)

Article  PubMed  PubMed Central  Google Scholar 

A.E. Feldstein, P. Charatcharoenwitthaya, S. Treeprasertsuk, J.T. Benson, F.B. Enders, P. Angulo, The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years. Gut. 58, 1538–1544 (2009)

Article  CAS  PubMed  Google Scholar 

J.B. Schwimmer, P.E. Pardee, J.E. Lavine, A.K. Blumkin, S. Cook, Cardiovascular risk factors and the metabolic syndrome in pediatric nonalcoholic fatty liver disease. Circulation. 118, 277–283 (2008)

Article  CAS  PubMed  PubMed Central  Google Scholar 

M.L. Geurtsen, S. Santos, J.F. Felix, L. Duijts, M.W. Vernooij, R. Gaillard et al. Liver fat and cardiometabolic risk factors among school‐age children. Hepatology. 72, 119–129 (2020)

Article  CAS  PubMed  Google Scholar 

Y.L. Liao, G.Y. Zhu, C. Chang, Non-alcoholic fatty liver disease increases the risk of cardiovascular disease in young adults and children: a systematic review and meta-analysis of cohort studies. Front. Cardiovasc. Med. 10, 1291438 (2024)

Article  PubMed  PubMed Central  Google Scholar 

E.L. Yu, J.B. Schwimmer, Epidemiology of pediatric nonalcoholic fatty liver disease. Clin. Liver Dis. 17, 196 (2021)

Article  Google Scholar 

A.K. Sahota, W.L. Shapiro, K.P. Newton, S.T. Kim, J. Chung, J.B. Schwimmer, Incidence of nonalcoholic fatty liver disease in children: 2009-2018. Pediatrics. 146, e20200771 (2020)

Article  PubMed  Google Scholar 

X. Zhang, M. Wu, Z. Liu, H. Yuan, X. Wu, T. Shi et al. Increasing prevalence of NAFLD/NASH among children, adolescents and young adults from 1990 to 2017: a population-based observational study. BMJ Open 11, e042843 (2021)

Article  PubMed  PubMed Central  Google Scholar 

P. Vajro, S. Lenta, P. Socha, A. Dhawan, P. McKiernan, U. Baumann et al. Diagnosis of nonalcoholic fatty liver disease in children and adolescents: position paper of the ESPGHAN Hepatology Committee. J. Pediatr. Gastroenterol. Nutr. 54, 700–713 (2012)

Article  PubMed  Google Scholar 

M.B. Vos, S.H. Abrams, S.E. Barlow, S. Caprio, S.R. Daniels, R. Kohli et al. NASPGHAN clinical practice guideline for the diagnosis and treatment of nonalcoholic fatty liver disease in children: recommendations from the Expert Committee on NAFLD (ECON) and the North American Society of Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN). J. Pediatr. Gastroenterol. Nutr. 64, 319–334 (2017)

Article  PubMed  PubMed Central  Google Scholar 

B.J. Perumpail, A.A. Li, N. John, S. Sallam, N.D. Shah, W. Kwong et al. The role of vitamin E in the treatment of NAFLD. Diseases 6, 86–96 (2018)

Article  CAS  PubMed  PubMed Central  Google Scholar 

P. Vajro, C. Mandato, A. Franzese, E. Ciccimarra, S. Lucariello, M. Savoia et al. Vitamin E treatment in pediatric obesity-related liver disease: a randomized study. J. Pediatr. Gastroenterol. Nutr. 38, 48–55 (2004)

CAS  PubMed  Google Scholar 

H. El Hadi, R. Vettor, M. Rossato, Vitamin E as a treatment for nonalcoholic fatty liver disease: reality or myth? Antioxidants. 7(1), 12 (2018)

Article  PubMed  Google Scholar 

K. Sato, M. Gosho, T. Yamamoto, Y. Kobayashi, N. Ishii, T. Ohashi et al. Vitamin E has a beneficial effect on nonalcoholic fatty liver disease: a meta-analysis of randomized controlled trials. Nutrition. 31, 923–930 (2015)

Article  CAS  PubMed  Google Scholar 

M. Rahimlou, H. Ahmadnia, A. Hekmatdoost, Dietary supplements and pediatric non-alcoholic fatty liver disease: Present and the future. World J. Hepatol. 7, 2597 (2015)

Article  PubMed  PubMed Central  Google Scholar 

Y. Park, S.A. Smith-Warner, X. Zhang, Y.J. Park, H. Kim, H. Park et al. Association between use of vitamin and mineral supplement and non-alcoholic fatty liver disease in hypertensive adults. Sci. Rep. 13, 1–13 (2023)

Google Scholar 

L.L. Wang, P.H. Zhang, H.H. Yan, Functional foods and dietary supplements in the management of non-alcoholic fatty liver disease: a systematic review and meta-analysis. Front. Nutr. 10, 1014010 (2023)

Article  PubMed  PubMed Central  Google Scholar 

A.F.G. Cicero, A. Colletti, S. Bellentani, Nutraceutical approach to Non-Alcoholic Fatty Liver Disease (NAFLD): the available clinical evidence. Nutrients. 10, 1153 (2018)

Article  PubMed  PubMed Central  Google Scholar 

M.E. Rinella, B.A. Neuschwander-Tetri, M.S. Siddiqui, M.F. Abdelmalek, S. Caldwell, D. Barb et al. AASLD practice guidance on the clinical assessment and management of nonalcoholic fatty liver disease. Hepatology. 77, 1797–1835 (2023)

Article  PubMed  Google Scholar 

Y. Xing, J. Fan, H.J. Wang, H. Wang, Comparison of MAFLD and NAFLD Characteristics in Children. Children. 10, 560 (2023)

Article  PubMed  PubMed Central  Google Scholar 

M.J. Page, J.E. McKenzie, P.M. Bossuyt, I. Boutron, T.C. Hoffmann, C.D. Mulrow et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372, 71 (2021)

Article  Google Scholar 

M.B. Vos, M.B. Weber, J. Welsh, F. Khatoon, D.P. Jones, P.F. Whitington et al. Fructose and oxidized low-density lipoprotein in pediatric nonalcoholic fatty liver disease: a pilot study. Arch. Pediatr. Adolesc. Med. 163, 674–675 (2009)

Article  PubMed  PubMed Central  Google Scholar 

S.S. Gidding, B.A. Dennison, L.L. Birch, S.R. Daniels, M.W. Gilman, A.H. Lichtenstein et al. Dietary recommendations for children and adolescents: a guide for practitioners: consensus statement from the American Heart Association. Circulation. 112, 2061–2075 (2005)

Article  CAS  PubMed  Google Scholar 

R. Jin, J.A. Welsh, N.A. Le, J. Holzberg, P. Sharma, D.R. Martin et al. Dietary fructose reduction improves markers of cardiovascular disease risk in hispanic-American Adolescents with NAFLD. Nutrients. 6, 3187 (2014)

Article  PubMed  PubMed Central  Google Scholar 

M. Ramon-Krauel, S.L. Salsberg, C.B. Ebbeling, S.D. Voss, R.V. Mulkern, M.M. Apura, et al. A low-glycemic-load versus low-fat diet in the treatment of fatty liver in obese children.Childhood Obes. 9, 252 (2013).

Article  Google Scholar 

J.B. Schwimmer, P. Ugalde-Nicalo, J.A. Welsh, J.E. Angeles, M. Cordero, K.E. Harlow et al. Effect of a low free sugar diet vs usual diet on nonalcoholic fatty liver disease in adolescent boys: a randomized clinical trial. JAMA. 321, 256–265 (2019)

Article  PubMed  PubMed Central  Google Scholar 

A.M. Goss, S. Dowla, M. Pendergrass, A. Ashraf, M. Bolding, S. Morrison et al. Effects of a carbohydrate-restricted diet on hepatic lipid content in adolescents with non-alcoholic fatty liver disease: a pilot, randomized trial. Pediatr. Obes. 15(7), e12630 (2020)

Article  PubMed  Google Scholar 

K. Hallsworth, G. Fattakhova, K.G. Hollingsworth, C. Thoma, S. Moore, R. Taylor et al. Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss. Gut. 60, 1278–1283 (2011)

Article  PubMed  Google Scholar 

E. Bacchi, C. Negri, G. Targher, N. Faccioli, M. Lanza, G. Zoppini et al. Both resistance training and aerobic training reduce hepatic fat content in type 2 diabetic subjects with nonalcoholic fatty liver disease (the RAED2 Randomized Trial). Hepatology. 58, 1287–1295 (2013)

Article  CAS  PubMed  Google Scholar 

S.J. Lee, F. Bacha, T. Hannon, J.L. Kuk, C. Boesch, S. Arslanian, Effects of aerobic versus resistance exercise without caloric restriction on abdominal fat, intrahepatic lipid, and insulin sensitivity in obese adolescent boys: a randomized, controlled trial. Diabetes. 61, 2787 (2012)

Article  CAS  PubMed  PubMed Central  Google Scholar 

S.J. Lee, A.R. Deldin, D. White, Y.M. Kim, I. Libman, M. Rivera-Vega et al. Aerobic exercise but not resistance exercise reduces intrahepatic lipid content and visceral fat and improves insulin sensitivity in obese adolescent girls: a randomized controlled trial. Am. J. Physiol. Endocrinol. Metab. 305(10), E1222–E1229 (2013)

Article  CAS  PubMed  PubMed Central  Google Scholar 

G.J. Van Der Heijden, Z.J. Wang, Z.D. Chu, P.J.J. Sauer, M.W. Haymond, L.M. Rodriguez et al. A 12-week aerobic exercise program reduces hepatic fat accumulation and insulin resistance in obese, Hispanic adolescents. Obesity 18, 384–390 (2010)

Article  PubMed  Google Scholar 

G.J. Van Der Heijden, Z.J. Wang, Z. Chu, G. Toffolo, E. Manesso, P.J.J. Sauer et al. Strength exercise improves muscle mass and hepatic insulin sensitivity in obese youth. Med. Sci. Sports Exercise 42, 1973–1980 (2010)

Article  Google Scholar 

A. De Piano, M.T. De Mello, P.D.L. Sanches, P.L. Da Silva, R.M.S. Campos, J. Carnier et al. Long-term effects of aerobic plus resistance training on the adipokines and neuropeptides in nonalcoholic fatty liver disease obese adolescents. Eur. J. Gastroenterol. Hepatol. 24, 1313–1324 (2012)

PubMed  Google Scholar 

I. Labayen, M. Medrano, L. Arenaza, E. Máz, M. Osés, V. Martínez-Vizcáno et al. Effects of exercise in addition to a family-based lifestyle intervention program on hepatic fat in children with overweight. Diabetes Care 43, 306–313 (2020)

Article  CAS  PubMed  Google Scholar 

P. Vajro, A. Fontanella, C. Perna, G. Orso, M. Tedesco, A. De Vincenzo, Persistent hyperaminotransferasemia resolving after weight reduction in obese children. J. Pediatr. 125, 239–241 (1994)

Article  CAS  PubMed  Google Scholar