L. Bartalena, M.L. Tanda, Current concepts regarding Graves’ orbitopathy. J. Intern. Med. 292(5), 692–716 (2022). https://doi.org/10.1111/joim.13524

Article  CAS  PubMed  PubMed Central  Google Scholar 

L. Bartalena, G.J. Kahaly, L. Baldeschi, C.M. Dayan, A. Eckstein, C. Marcocci, M. Marinò, B. Vaidya, W.M. Wiersinga; EUGOGO, The 2021 European Group on Graves’ orbitopathy (EUGOGO) clinical practice guidelines for the medical management of Graves’ orbitopathy. Eur. J. Endocrinol. 185(4), G43–G67 (2021). https://doi.org/10.1530/EJE-21-0479

Article  CAS  PubMed  Google Scholar 

L. Bartalena, W.M. Wiersinga, Proposal for standardization of primary and secondary outcomes in patients with active, moderate-to-severe graves’ orbitopathy. Eu. Thyroid J. 9, 3–16 (2020). https://doi.org/10.1159/000510700

Article  CAS  Google Scholar 

A. Eckstein, M. Schittkowski, J. Esser, Surgical treatment of Graves’ ophthalmopathy. Best. Pract. Res. Clin. Endocrinol. Metab. 26, 339–358 (2012). https://doi.org/10.1016/j.beem.2011.11.002

Article  PubMed  Google Scholar 

I. San Miguel, M. Arenas, R. Carmona, J. Rutllan, F. Medina-Rivero, P. Lara, Review of the treatment of Graves’ ophthalmopathy: The role of the new radiation techniques. Saudi J. Ophthalmol. 32(2), 139–145 (2018). https://doi.org/10.1016/j.sjopt.2017.09.003

Article  PubMed  Google Scholar 

M.L. Tanda, L. Bartalena, Efficacy and safety of orbital radiotherapy for graves’ orbitopathy. J. Clin. Endocrinol. Metab. 97(11), 3857–3865 (2012). https://doi.org/10.1210/jc.2012-2758

Article  CAS  PubMed  Google Scholar 

T. Weissmann, S. Lettmaier, A.J. Donaubauer, C. Bert, M. Schmidt, F. Kruse, O. Ott, M. Hecht, R. Fietkau, B. Frey, F: Putz, Low- vs. high-dose radiotherapy in Graves’ ophthalmopathy: A retrospective comparison of long-term results. Strahlenther. Onkol. 197(10), 885–894 (2021). https://doi.org/10.1007/s00066-021-01770-9

Article  PubMed  PubMed Central  Google Scholar 

H.B. Burch, P. Perros, T. Bednarczuk, D.S. Cooper, P.J. Dolman, A.M. Leung, I. Mombaerts, M. Salvi, M.N. Stan, Management of Thyroid Eye Disease: A Consensus Statement by the American Thyroid Association and the European Thyroid Association. Eur. Thyroid J. 32(12), 1439–1470 (2022). https://doi.org/10.1530/ETJ-22-0189

Article  Google Scholar 

G.J. Kahaly, H.P. Rösler, S. Pitz, G. Hommel, Low- versus high-dose radiotherapy for Graves’ ophthalmopathy: A randomized, single blind trial. J. Clin. Endocrinol. Metab. 85(1), 102–8 (2000). https://doi.org/10.1210/jcem.85.1.6257

Article  CAS  PubMed  Google Scholar 

J. Gerling, G. Kommerell, K. Henne, J. Laubenberger, J. Schulte-Mönting, P. Fells, Retrobulbar irradiation for thyroid-associated orbitopathy: double-blind comparison between 2.4 and 16 Gy. Int. J. Radiat. Oncol. Biol. Phys. 55(1), 182–9 (2003). https://doi.org/10.1016/s0360-3016(02)03795-1

Article  PubMed  Google Scholar 

S.S. Donaldson, M.A. Bagshaw, J.P. Kriss, Supervoltage orbital radiotherapy for Graves’ ophthalmopathy. J. Clin. Endocrinol. Metab. 37(2), 276–85 (1973). https://doi.org/10.1210/jcem-37-2-276

Article  CAS  PubMed  Google Scholar 

E. Sisti, F. Menconi, M. Leo, M.A. Profilo, T. Mautone, B. Mazzi, R. Rocchi, F. Latrofa, M. Nardi, P. Vitti, C. Marcocci, M. Marinò, Long-term outcome of Graves’ orbitopathy following high-dose intravenous glucocorticoids and orbital radiotherapy. J. Endocrinol. Invest. 38(6), 661–8 (2015). https://doi.org/10.1007/s40618-015-0241-7

Article  CAS  PubMed  Google Scholar 

L. Nicosia, C. Reverberi, L. Agolli, L. Marinelli, V. De Sanctis, G. Minniti, M. Valeriani, M.F. Osti, Orbital radiotherapy plus concomitant steroids in moderate-to-severe Graves’ ophthalmopathy: Good results after long-term follow-up. Int. J. Endocrinol. Metab. 27 17(1), e84427 (2019). https://doi.org/10.5812/ijem.84427

Article  Google Scholar 

M.F. Prummel, M.P. Mourits, L. Blank, A. Berghout, L. Koornneef, W.M: Wiersinga, Randomized double-blind trial of prednisone versus radiotherapy in Graves’ ophthalmopathy. Lancet 16 342(8877), 949–54 (1993). https://doi.org/10.1016/0140-6736(93)92001-a

Article  CAS  Google Scholar 

S. Zang, K.A. Ponto, G.J. Kahaly, Clinical review: Intravenous glucocorticoids for Graves’ orbitopathy: Efficacy and morbidity. J. Clin. Endocrinol. Metab. 96(2), 320–32 (2011). https://doi.org/10.1210/jc.2010-1962

Article  CAS  PubMed  Google Scholar 

L. Bartalena, C. Marcocci, L. Chiovato, M. Laddaga, G. Lepri, D. Andreani, G. Cavallacci, L. Baschieri, A. Pinchera, Orbital cobalt irradiation combined with systemic corticosteroids for Graves’ ophthalmopathy: Comparison with systemic corticosteroids alone. J. Clin. Endocrinol. Metab. 56(6), 1139–1144 (1983). https://doi.org/10.1210/jcem-56-6-1139

Article  CAS  PubMed  Google Scholar 

C.M. Ng, H.K. Yuen, K.L. Choi, M.K. Chan, K.T. Yuen, Y.W. Ng, S.C. Tiu, Combined orbital irradiation and systemic steroids compared with systemic steroids alone in the management of moderate-to-severe Graves’ ophthalmopathy: a preliminary study. Hong. Kong Med. J. 11(5), 322–30 (2005)

CAS  PubMed  Google Scholar 

C. Marcocci, L. Bartalena, F. Bogazzi, G. Bruno-Bossio, A. Lepri, A. Pinchera, Orbital radiotherapy combined with high dose systemic glucocorticoids is more effective than radiotherapy alone:. results of a prospective randomized study. J. Endocrinol. Invest. 14, 853–860 (1991). https://doi.org/10.1007/BF03347943

Article  CAS  PubMed  Google Scholar 

M. Oeverhaus, T. Witteler, H. Lax, J. Esser, D. Führer, A. Eckstein, Combination therapy of intravenous steroids and orbital irradiation is more effective than intravenous steroids alone in patients with Graves’ orbitopathy. Horm. Metab. Res. 49(10), 739–747 (2017). https://doi.org/10.1055/s-0043-116945

Article  CAS  PubMed  Google Scholar 

L. Bartalena, C. Marcocci, M.L. Tanda, R. Rocchi, B. Mazzi, G. Barbesino, A. Pinchera, Orbital radiotherapy for Graves’ ophthalmopathy. Thyroid 12(3), 245–50 (2002). https://doi.org/10.1089/105072502753600223

Article  PubMed  Google Scholar 

C.A. Gorman, J.A. Garrity, V. Fatourechi, R.S. Bahn, I.A. Petersen, S.L. Stafford, J.D. Earle, G.S. Forbes, R.W. Kline, H. Buettner, D.M. Robertson, E.J. Bergstralh, K.P. Offord, D.M. Rademacher, N.M. Stanley, G.B. Bartley, The aftermath of orbital radiotherapy for graves’ ophthalmopathy. Ophthalmology 109(11), 2100–7 (2002). https://doi.org/10.1016/s0161-6420(02)01293-9

Article  PubMed  Google Scholar 

J.W. Kim, S.H. Han, B.J. Son, T.H. Rim, K.C. Keum, J.S. Yoon, Efficacy of combined orbital radiation and systemic steroids in the management of Graves’ orbitopathy. Graefes Arch. Clin. Exp. Ophthalmol. 254(5), 991–998 (2016). https://doi.org/10.1007/s00417-016-3280-7

Article  PubMed  Google Scholar 

E. Hahn, N. Laperriere, B. Millar, J. Oestreicher, H. McGowan, H. Krema, H. Gill, D. DeAngelis, J. Hurwitz, N. Tucker, R. Simpson, C: Chung, Orbital radiation therapy for Graves’ ophthalmopathy: Measuring clinical efficacy and impact. Pract. Radiat. Oncol. 4(4), 233–9 (2014). https://doi.org/10.1016/j.prro.2014.02.008

Article  PubMed  Google Scholar 

C. Matthiesen, J.S. Thompson, D. Thompson, B. Farris, B. Wilkes, S. Ahmad, T. Herman, C. Bogardus Jr, The efficacy of radiation therapy in the treatment of Graves’ orbitopathy. Int. J. Radiat. Oncol. Biol. Phys. 82(1), 117–23 (2012). https://doi.org/10.1016/j.ijrobp.2010.08.053

Article  PubMed  Google Scholar 

Y.J. Li, Y. Luo, X.Q. Xie, W.M. He, C. Yi, P. Li, F. Wang, The efficacy of intensity modulated radiation therapy in treating thyroid-associated ophthalmopathy and predictive factors for treatment response. Sci. Rep. 7, 17533 (2017). https://doi.org/10.1038/s41598-017-17893-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

R.S. Prabhu, L. Liebman, T. Wojno, B. Hayek, W.A. Hall, I. Crocker, Clinical outcomes of radiotherapy as initial local therapy for Graves’ ophthalmopathy and predictors of the need for post-radiotherapy decompressive surgery. Radiat. Oncol. 19(7), 95 (2012). https://doi.org/10.1186/1748-717X-7-95

Article  Google Scholar 

J. Choi, J. Lee, Efficacy of orbital radiotherapy in moderate-to-severe active graves’ orbitopathy including long-lasting disease: a retrospective analysis. Radiat. Oncol. 15(1), 220 (2020). https://doi.org/10.1186/s13014-020-01663-8

Article  PubMed  PubMed Central  Google Scholar 

L. Baldeschi, A. Lupetti, P. Vu, I.M. Wakelkamp, M.F. Prummel, W.M. Wiersinga, Reactivation of Graves’ orbitopathy after rehabilitative orbital decompression. Ophthalmology 114(7), 1395–402 (2007). https://doi.org/10.1016/j.ophtha.2006.10.036

Article  PubMed  Google Scholar