High-performance thin-layer chromatography‒spectrodensitometric determination of diltiazem hydrochloride and its commonly occurring degradation impurity

National Center for Biotechnology Information (2023) PubChem Compound Summary for CID 62920, diltiazem hydrochloride. Accessed 5 Oct 2023

Neutel JM, Smith D, Weber M (1999) Is high blood pressure a late manifestation of hypertension syndrome? Am J Hypertens 12:215–223

Article  Google Scholar 

Leonard RG, Talbert RL (1982) Calcium-channel blocking agents. Clin Pharm 1:17–33

CAS  PubMed  Google Scholar 

Diltiazem hydrochloride (2010) Indian Pharmacopeia, Volume I. Indian Pharmacopoeia Commission, Ghaziabad, 155

Glossmann H, Ferry DR, Goll A, Rombusch M (1984) Molecular pharmacology of the calcium channel: evidence for subtypes, multiple drug-receptor sites, channel subunits, and the development of a radio iodinated 1,4-dihydropyridine calcium channel label, [125I] iopidine. J Cardiovasc Pharmacol 6:S608–S621

Article  PubMed  Google Scholar 

O’Neil MJ, Heckelman PE, Koch CB, Roman KJ (eds) (2006) The Merck Index. An encyclopaedia of chemicals, drugs and biological, 14th edn. Division of Merck and Co. Inc., Whitehouse Station

Google Scholar 

United States Pharmacopeia (2000) XXIV. United States Pharmacopeial Convention, Rockville, MD, 573–576

Diltiazem hydrochloride (2017) European Pharmacopeia 10.0. European Pharmacopoeia Commission, Strasbourg, 2424

Agarwal R, Mishra P, Bansal B (2022) Understanding degradation pathway of poorly stable diltiazem hydrochloride and development of its stabilized controlled-release tablets. Int J Drug Deliv Technol 12(4):1646–1649

Article  Google Scholar 

Eyad SM, Abu-Nameh A (2013) A validated stability indicating HPLC method for determination of diltiazem hydrochloride in tablet dosage form. Aust J Basic Appl Sci 7(6):730–736

Google Scholar 

Mosab A (2014) Simple HPLC validated method for the determination of diltiazem hydrochloride in human plasma. Int J Pharm Pharm Sci 6(9):213–216

Google Scholar 

Mahajan N, Deshmukh S, Farooqui M (2021) A novel stability indicating method for known and unknown impurities profiling for diltiazem hydrochloride pharmaceutical dosage form (tablets). Futur J Pharm Sci 7:204

Article  Google Scholar 

Abu-shandi KH (2014) HPLC method development for the simultaneous determination and validation of diltiazem hydrochloride and its major metabolite desacetyl diltiazem hydrochloride. Pharm Chem 6(6):358–365

Google Scholar 

Chatpalliwar VA, Porwal PK, Upmanyu N (2012) Validated gradient stability indicating HPLC method for determining diltiazem hydrochloride and related substance in bulk drug and novel tablet formulation. J Pharm Anal 2(3):226–2237

Article  CAS  PubMed  PubMed Central  Google Scholar 

Patill BR, Bhusnure OG, Paul BN, Ghodke AY, Mulaje SS (2014) Analytical method development and validation for the estimation of diltiazem hydrochloride in bulk and pharmaceutical dosage form by RP-HPLC. Int J Drug Regul Aff 2(2):78–84

Article  Google Scholar 

Devarajan PV, Dhavse VV (1998) High-performance thin-layer chromatographic determination of diltiazem hydrochloride as bulk drug and in pharmaceutical preparations. J Chromatogr B Biomed Sci Appl 706(2):362–366

Article  CAS  PubMed  Google Scholar 

International Conference on Harmonization (2005) Q2R1: harmonized tripartite guideline, validation of analytical procedures: text and methodology, IFPMA, Geneva

Agbaba D, Solomun LJ, Zivanov-stakic D (1997) Simultaneous HPTLC determination of diltiazem and its impurity deacetyldiltiazem in raw material and in dosage form. J Planar Chromatogr-Mod TLC 10(4):303–304

CAS  Google Scholar 

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