Does Topical Vancomycin Powder Use in Fracture Surgery Change Bacteriology and Antibiotic Susceptibilities? An Analysis of the VANCO Trial

aDivision of Infectious Disease, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD;

bDepartment of Orthopaedics, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD;

cDepartment of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD;

dDepartment of Orthopaedic Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, CA;

eDepartment of Orthopaedic Surgery, Vanderbilt University Medical Center, Nashville, TN;

fSan Antonio Military Medical Center, San Antonio, TX;

gInova Fairfax Hospital, Fairfax, VA;

hDepartment of Orthopaedics and Rehabilitation, Penn State Health Milton S. Hershey Medical Center, Hershey, PA;

iUniversity of Michigan School of Dentistry, Ann Arbor, MI;

jDepartment of Orthopedics and Rehabilitation, University of Wisconsin, Madison, WI; and

kDepartment of Orthopaedics, Louisiana State University Health Sciences Center, New Orleans, LA.

Reprints: Robert V. O'Toole, MD, Department of Orthopaedics, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, 22 South Greene St, T3N26, Baltimore, MD 21201 (e-mail: [email protected]).

No external funding was received for this work. Work on the original VANCO study was supported by US Department of Defense CDMRP award #W81XWH-10-2-0134. The original sponsor had no role in the design or conduct of the trial; the collection, management, analysis, or interpretation of this data; or the preparation, review, or approval of this manuscript for submission.

The authors report no conflict of interest.

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