Horm Metab Res
DOI: 10.1055/a-2268-8114
Original Article: Endocrine Care
Yanhong Huo
1
Department of Nephrology, First Medical Center of Chinese PLA General
Hospital, Nephrology Institute of the Chinese People's Liberation Army,
Beijing, China
,
Xin Zhang
1
Department of Nephrology, First Medical Center of Chinese PLA General
Hospital, Nephrology Institute of the Chinese People's Liberation Army,
Beijing, China
,
Li Su
1
Department of Nephrology, First Medical Center of Chinese PLA General
Hospital, Nephrology Institute of the Chinese People's Liberation Army,
Beijing, China
,
Yan Zhang
2
Department of Ophthalmology, Seventh Medical Center of Chinese PLA
General Hospital, Beijing, China
› Author Affiliations
Funding Information
Beijing Municipal Science & Technology Commission — Z171100001017163
The Beijing Natural Science Foundation — 7162048
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Abstract
The objective of this study is to explore the relationship between the vascular
endothelial growth factor (VEGF)+936 C/T polymorphism and the risk of type 2
diabetic retinopathy (T2DR) by a method of meta-analysis. Six online databases
were queried to identify studies investigating the VEGF+936 C/T polymorphism
that influenced T2DR up to August 2023. The statistical tool of the pooled data
was adopted using Stata 15.0 software. The experimental group comprised patients
with T2DR, while patients with type 2 diabetes mellitus without retinopathy were
considered as the controls. The odds ratio (OR) was utilized as effect size.
Eight eligible publications were identified in this review, including 1546
patients with T2DR. The combined results revealed that the VEGF+936 C/T
polymorphism was significantly associated with the T2DR risk under the allelic
(C/T: OR=0.54, p<0.001), the dominant (CC+CT/TT: OR=0.37, p<0.001),
recessive (CC/CT+TT: OR=0.52, p=0.001), homozygous (CC/TT: OR=0.31, p<0.001),
and heterozygous (CT/TT: OR=0.55, p=0.005) gene models. No significant
correlation was observed regarding the VEGF+936 C/T polymorphism that
contributed to the risk of proliferative diabetic retinopathy (PDR) versus
non-PDR. In conclusion, the VEGF+936 C/T polymorphism significantly contributed
to the T2DR risk. Specifically, at the VEGF+936 C/T locus, the presence of
allele C and genotypes CC, CT, and CC+CT were found to be associated with a
reduced risk of T2DR.
Keywords
meta-analysis -
susceptibility -
diabetic retinopathy -
polymorphism
Publication History
Received: 13 September 2023
Accepted: 09 February 2024
Article published online:
12 March 2024
© 2024. Thieme. All rights reserved.
Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart,
Germany
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