• Burani K, Brush CJ, Shields GS, Klein DN, Nelson B, Slavich GM, Hajcak G. Cumulative lifetime acute stressor exposure interacts with reward responsiveness to predict longitudinal increases in depression severity in adolescence. Psychol Med. 2023;53:4507–16. Major life stressors predict depressive symptoms in girls, although robust reward responsiveness may be protective. Here, greater lifetime acute stressor exposure predicted increases in depressive symptoms over 2 years, but only for those exhibiting blunted reward responsiveness.
Slavich GM, Irwin MR. From stress to inflammation and major depressive disorder: a Social Signal Transduction Theory of Depression. Psychol Bull. 2014;140:774–15. Stress, but especially experiences of social threat and adversity, upregulate components of the immune system involved in inflammation, resulting in depressive symptoms for vulnerable individuals.
Centers for Disease Control and Prevention (CDC). Youth risk behavior survey data summary & trends report. 2023;2011–21.
Salk RH, Hyde JS, Abramson LY. Gender differences in depression in representative national samples: meta-analyses of diagnoses and symptoms. Psychol Bull. 2017;143:783–22.
• Slavich GM, Sacher J. Stress, sex hormones, inflammation, and major depressive disorder: extending Social Signal Transduction Theory of Depression to account for sex differences in mood disorders. Psychopharmacology. 2019;236:3063–79. Sex steroid hormone fluctuations modulate women’s susceptibility to stress, brain structure and function, and inflammatory activity and reactivity, varying as a function of sex, age, reproductive state, endogenous versus exogenous hormones, and hormone administration method and dose. Together, these effects help explain women’s increased risk for inflammation-related depression and other inflammation-related disorders.
Article CAS PubMed Google Scholar
Slavich GM. Psychoneuroimmunology of stress and mental health. In: Harkness KL, Hayden EP, editors. The Oxford handbook of stress and mental health. Oxford University Press; 2020;518–46.
Slavich GM, Auerbach RP. Stress and its sequelae: depression, suicide, inflammation, and physical illness. In: Butcher JN, Hooley JM (eds) APA handbook of psychopathology: psychopathology: understanding, assessing, and treating adult mental disorders. Am Psychol Assoc, Washington. 2018;1:375–40.
• Madison AA, Andridge R, Shrout MR, Renna ME, Bennett JM, Jaremka LM, et al. Frequent interpersonal stress and inflammatory reactivity predict depressive-symptom increases: two tests of the Social-Signal-Transduction Theory of Depression. Psychol Sci. 2022;33(1):152–64. In two studies, interpersonal stress (and not other types of stress) interacted with inflammatory reactivity to predict the subsequent development of depressive symptoms, providing empirical support for the Social Signal Transduction Theory of Depression.
•• Slavich GM, Giletta M, Helms SW, Hastings PD, Rudolph KD, Nock MK, Prinstein MJ. Interpersonal life stress, inflammation, and depression in adolescence: testing Social Signal Transduction Theory of Depression. Depress Anxiety. 2020;37(2):179–93. Heightened inflammatory reactivity to social stress predicted depression in adolescent girls who experienced interpersonal or social stressors, providing support for the Social Signal Transduction Theory of Depression.
Moieni M, Irwin MR, Jevtic I, Olmstead R, Breen EC, Eisenberger NI. Sex differences in depressive and socioemotional responses to an inflammatory challenge: implications for sex differences in depression. Neuropsychopharmacol. 2015;40(7):1709–16.
Derry HM, Padin AC, Kuo JL, Hughes S, Kiecolt-Glaser JK. Sex differences in depression: does inflammation play a role? Curr Psychiatry Rep. 2015;17(10):78.
Sutherland S, Brunwasser SM. Sex differences in vulnerability to prenatal stress: a review of the recent literature. Curr Psychiatry Rep. 2018;20:102.
Shao S, Wang J, Huang K, Wang S, Liu H, Wan S, Yan S, Hao J, Zhu P, Tao F. Prenatal pregnancy-related anxiety predicts boys’ ADHD symptoms via placental C-reactive protein. Psychoneuroendocrinology. 2020;120:104797.
Article CAS PubMed Google Scholar
Kim D-J, Davis EP, Sandman CA, Sporns O, O’Donnell BF, Buss C, Hetrick WP. Prenatal maternal cortisol has sex-specific associations with child brain network properties. Cereb Cortex. 2017;27:5230–41.
Hodes GE, Epperson CN. Sex differences in vulnerability and resilience to stress across the life span. Biol Psychiat. 2019;86:421–32.
Miller GE, Chen E. Harsh family climate in early life presages the emergence of a proinflammatory phenotype in adolescence. Psychol Sci. 2010;21:848–56.
Baldwin JR, Arseneault L, Caspi A, et al. Childhood victimization and inflammation in young adulthood: a genetically sensitive cohort study. Brain Behav Immun. 2018;67:211–7.
Kim S, Watt T, Ceballos N, Sharma S. Adverse childhood experiences and neuroinflammatory biomarkers—the role of sex. Stress Health. 2019;35:432–40.
• Furman D, Campisi J, Verdin E, et al. Chronic inflammation in the etiology of disease across the life span. Nat Med. 2019;25:1822–32. Childhood adversity and family dysfunction impact C-reactive protein (CRP), with family dysfunction predicting elevated CRP more strongly in women compared to men, highlighting sex differences in the susceptibility to early life stress.
Article CAS PubMed Google Scholar
Slavich GM. Understanding inflammation, its regulation, and relevance for health: a top scientific and public priority. Brain Behav Immun. 2015;45:13–4.
Klein SL, Flanagan KL. Sex differences in immune responses. Nat Rev Immunol. 2016;16:626–38.
Article CAS PubMed Google Scholar
Klein SL. The effects of hormones on sex differences in infection: from genes to behavior. Neurosci Biobehav Rev. 2000;24:627–38.
Article CAS PubMed Google Scholar
Villa A, Vegeto E, Poletti A, Maggi A. Estrogens, neuroinflammation, and neurodegeneration. Endocr Rev. 2016;37:372–402.
Article CAS PubMed Google Scholar
Gilliver SC. Sex steroids as inflammatory regulators. J Steroid Biochem Mol Biol. 2010;120:105–15.
Article CAS PubMed Google Scholar
Hayter SM, Cook MC. Updated assessment of the prevalence, spectrum and case definition of autoimmune disease. Autoimmun Rev. 2012;11:754–65.
Barnabei L, Laplantine E, Mbongo W, Rieux-Laucat F, Weil R. NF-κB: at the borders of autoimmunity and inflammation. Front Immunol. 2021;12.
Neurath MF, Finotto S. IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer. Cytokine Growth Factor Rev. 2011;22(2):83–9.
Article CAS PubMed Google Scholar
Sharif K, Watad A, Coplan L, Lichtbroun B, Krosser A, Lichtbroun M, et al. The role of stress in the mosaic of autoimmunity: an overlooked association. Autoimmun Rev. 2018;17(10):967–83.
Article CAS PubMed Google Scholar
Ge X, Conger RD, Elder GH. Pubertal transition, stressful life events, and the emergence of gender differences in adolescent depressive symptoms. Dev Psychol. 2001;37(3):404–17.
Article CAS PubMed Google Scholar
Burke CS, Susser LC, Hermann AD. GABAA dysregulation as an explanatory model for late-onset postpartum depression associated with weaning and resumption of menstruation. Arch Womens Ment Health. 2019;22(1):55–63.
Smith SS. The influence of stress at puberty on mood and learning: role of the α4βδ GABAA receptor. Neuroscience. 2013;249:192–213.
Article CAS PubMed Google Scholar
Frokjaer VG, Pinborg A, Holst KK, Overgaard A, Henningsson S, Heede M, et al. Role of serotonin transporter changes in depressive responses to sex-steroid hormone manipulation: a positron emission tomography study. Biol Psychiat. 2015;78(8):534–43.
Article CAS PubMed Google Scholar
Mehta D, Rex-Haffner M, Søndergaard HB, Pinborg A, Binder EB, Frokjaer VG. Evidence for oestrogen sensitivity in perinatal depression: pharmacological sex hormone manipulation study. Br J Psychiatry. 2019;215(3):519–27.
Nadel MV. (Testimony) problems in implementing policy on women in study populations, Subcommittee on Housing and Consumer Interest and Select Committee on Aging, House of Representatives, 101st Congress. 1990.
• Kirschbaum C, Kudielka BM, Gaab J, Schommer NC, Hellhammer DH. Impact of gender, menstrual cycle phase, and oral contraceptives on the activity of the hypothalamus-pituitary-adrenal axis. Psychosom Med. 1999;61:154 Men have a more pronounced cortisol response to acute psychosocial stress compared to women, who have a more pronounced cortisol response to stress compared to hormonal contraceptive users.
Article CAS PubMed Google Scholar
• Rrapaj A, Landau AM, Winterdahl M. Exploration of possible sex bias in acute social stress research: a semi-systematic review. Acta Neuropsychiatr. 2023;35:205–17. Despite increases in female inclusion in clinical research in recent years, female participants were significantly underrepresented in acute social stress research published over the last 20 years. More than half of the articles that included data from both sexes failed to analyze the results by sex, and even more contained other significant methodological limitations.
Larsen B, Cox A, Colbey C, Drew M, McGuire H, Fazekas de St Groth B, et al. Inflammation and oral contraceptive use in female athletes before the Rio Olympic games. Front Physiol. 2020;11:497.
Lovallo WR, Cohoon AJ, Acheson A, Vincent AS, Sorocco KH. Cortisol stress reactivity in women, diurnal variations, and hormonal contraceptives: studies from the Family Health Patterns Project. Stress. 2019;22:421–7.
• Masama C, Jarkas DA, Thaw E, Daneshmend AZB, Franklyn SI, Beaurepaire C, McQuaid RJ. Hormone contraceptive use in young women: altered mood states, neuroendocrine and inflammatory biomarkers. Horm Behav. 2022;144: 105229. Hormonal contraceptive use is associated with elevated levels of C-reactive protein (CRP), a marker of systemic inflammation, along with elevated depressive and stress scores.
Article CAS PubMed Google Scholar
•• Mengelkoch S, Gassen J, Slavich GM, Hill SE. Hormonal contraceptive use is associated with differences in women’s inflammatory and psychological reactivity to an acute social stressor. Brain Behav Immun. 2023;115:747–57. This study demonstrated that hormonal contraceptive use may alter inflammatory reactivity to social stress in ways that increase women’s risk for depression and was the first study to assess how hormonal contraceptive use is associated with inflammatory reactivity to acute stress in vivo.
Nielsen SE, Segal SK, Worden IV, Yim IS, Cahill L. Hormonal contraception use alters stress responses and emotional memory. Biol Psychol. 2013;92:257–66.
Roche DJO, King AC, Cohoon AJ, Lovallo WR. Hormonal contraceptive use diminishes salivary cortisol response to psychosocial stress and naltrexone in healthy women. Pharmacol Biochem Behav. 2013;109:84–9.
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