Obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) are prevalent respiratory diseases.1 Coexistence of the two conditions, known as the OSA-COPD overlap syndrome (OS), has been associated with a significantly elevated risk of developing pulmonary hypertension (PH) and worse clinical outcomes.2, 3, 4, 5, 6, 7 The right heart catheterization (RHC) is the gold standard for accurately diagnosing PH at an early stage. During the past two decades, several studies have concerned the PH in patients with OS.2, 3, 4 However, the clinical and hemodynamic characteristics of PH patients with OS remain relatively underexplored. Therefore, this study aimed to investigate the specific features of PH in patients with OS by comparing them to individuals with COPD or OSA.