Determination of cortisol cut-off limits and steroid dynamics in the ACTH stimulation test: a comparative analysis using Roche Elecsys Cortisol II immunoassay and LC-MS/MS

Y. Simsek, Z. Karaca, F. Tanriverdi, K. Unluhizarci, A. Selcuklu, F. Kelestimur, A comparison of low-dose ACTH, glucagon stimulation and insulin tolerance test in patients with pituitary disorders. Clin. Endocrinol. 82, 45–52 (2015). https://doi.org/10.1111/cen.12528

Article  CAS  Google Scholar 

T.A.M. Abdu, T.A. Elhadd, R. Neary, R.N. Clayton, Comparison of the Low Dose Short Synacthen Test (1 µg), the Conventional Dose Short Synacthen Test (250 µg), and the Insulin Tolerance Test for Assessment of the Hypothalamo-Pituitary-Adrenal Axis in Patients with Pituitary Disease. J. Clin. Endocrinol. Metab. 84, 839–843 (1999). https://doi.org/10.1210/jcem.84.3.5535

Article  Google Scholar 

M.H. Laudat, S. Cerdas, C. Fournier, D. Guiban, B. Guilhaume, J.P. Luton, Salivary Cortisol Measurement: A Practical Approach to Assess Pituitary-Adrenal Function. J. Clin. Endocrinol. Metab. 66, 343–348 (1988). https://doi.org/10.1210/jcem-66-2-343

Article  CAS  PubMed  Google Scholar 

M. Klose, M. Lange, A.K. Rasmussen, N.E. Skakkebæk, L. Hilsted, E. Haug, M. Andersen, U. Feldt-Rasmussen, Factors influencing the adrenocorticotropin test: Role of contemporary cortisol assays, body composition, and oral contraceptive agents. J. Clin. Endocrinol. Metab. 92, 1326–1333 (2007). https://doi.org/10.1210/jc.2006-1791

Article  CAS  PubMed  Google Scholar 

H.Y. Cho, J.H. Kim, S.W. Kim, C.S. Shin, K.S. Park, S.W. Kim, H.C. Jang, S.Y. Kim, Different cut-off values of the insulin tolerance test, the high-dose short Synacthen test (250 μg) and the low-dose short Synacthen test (1 μg) in assessing central adrenal insufficiency. Clin. Endocrinol. 81, 77–84 (2014). https://doi.org/10.1111/cen.12397

Article  CAS  Google Scholar 

J. Gonzálbez, C. Villabona, J. Ramón, M.A. Navarro, O. Giménez, W. Ricart, J. Soler, Establishment of reference values for standard dose short synacthen test (250 μg), low dose short synacthen test (1 μg) and insulin tolerance test for assessment of the hypothalamo-pituitary-adrenal axis in normal subjects. Clin. Endocrinol. 53, 199–204 (2000). https://doi.org/10.1046/j.1365-2265.2000.01028.x

Article  Google Scholar 

N. El-Farhan, A. Pickett, D. Ducroq, C. Bailey, K. Mitchem, N. Morgan, A. Armston, L. Jones, C. Evans, D.A. Rees, Method-specific serum cortisol responses to the adrenocorticotrophin test: Comparison of gas chromatography-mass spectrometry and five automated immunoassays. Clin. Endocrinol. 78, 673–680 (2013). https://doi.org/10.1111/cen.12039

Article  CAS  Google Scholar 

J. Lindholm, H. Kehlet, Re-evaluation of the clinical value of the 30 min ACTH test in assessing the hypothalamic-pituitary-adrenocortical function. Clin. Endocrinol. 26, 53–59 (1987). https://doi.org/10.1111/j.1365-2265.1987.tb03638.x

Article  CAS  Google Scholar 

J. Wood, A. Frankland, V.H.T. James, J. Landon, A rapid test of adrenocortical function. Lancet 234, 243–245 (1965). https://doi.org/10.1016/s0140-6736(65)91526-6

Article  Google Scholar 

M.H. Choi, Clinical and Technical Aspects in Free Cortisol Measurement. Endocrinol. Metab. 37, 599–607 (2022). https://doi.org/10.3803/EnM.2022.1549

Article  CAS  Google Scholar 

G. Casals, F.A. Hanzu, Cortisol measurements in Cushing’s syndrome: Immunoassay or mass spectrometry? Ann. Lab. Med. 40, 285–296 (2020). https://doi.org/10.3343/alm.2020.40.4.285

Article  CAS  PubMed  PubMed Central  Google Scholar 

G.A. Kline, J. Buse, R.D. Krause, Clinical implications for biochemical diagnostic thresholds of adrenal sufficiency using a highly specific cortisol immunoassay. Clin. Biochem. 50, 475–480 (2017). https://doi.org/10.1016/j.clinbiochem.2017.02.008

Article  CAS  PubMed  Google Scholar 

V. Raverot, C. Richet, Y. Morel, G. Raverot, F. Borson-Chazot, Establishment of revised diagnostic cut-offs for adrenal laboratory investigation using the new Roche Diagnostics Elecsys® Cortisol II assay. Ann. Endocrinol. 77, 620–622 (2016). https://doi.org/10.1016/j.ando.2016.05.002

Article  Google Scholar 

G.A. Ueland, P. Methlie, M. Øksnes, H.B. Thordarson, J. Sagen, R. Kellmann, G. Mellgren, M. Ræder, P. Dahlqvist, S.R. Dahl, P.M. Thorsby, K. Løvås, E.S. Husebye, The Short Cosyntropin Test Revisited: New Normal Reference Range Using LC-MS/MS. J. Clin. Endocrinol. Metab. 103, 1696–1703 (2018). https://doi.org/10.1210/jc.2017-02602

Article  PubMed  Google Scholar 

G. Grassi, V. Morelli, F. Ceriotti, E. Polledri, S. Fustinoni, S. D’agostino, G. Mantovani, I. Chiodini, M. Arosio, Minding the gap between cortisol levels measured with second-generation assays and current diagnostic thresholds for the diagnosis of adrenal insufficiency: a single-center experience. Hormones 19, 425–431 (2000). https://doi.org/10.1007/s42000-020-00185-y

Article  Google Scholar 

L. Zha, J. Li, S.M. Krishnan, M.R. Brennan, Y.V. Zhang, P. Povse, R. Kerlin, K. Shively, F. Oleksik, J.A. Williams, E. Sykes, Q. Sun, New Diagnostic Cutoffs for Adrenal Insufficiency After Cosyntropin Stimulation Using Abbott Architect Cortisol Immunoassay. Endocr. Pr. 28, 684–689 (2022). https://doi.org/10.1016/J.EPRAC.2022.04.003

Article  Google Scholar 

H. Husni, M.S. Abusamaan, R. Dinparastisaleh, L. Sokoll, R. Salvatori, A.H. Hamrahian, Cortisol values during the standard-dose cosyntropin stimulation test: Personal experience with Elecsys cortisol II assay. Front Endocrinol. 13, 1–7 (2022). https://doi.org/10.3389/fendo.2022.978238

Article  Google Scholar 

B.R. Javorsky, H. Raff, T.B. Carroll, A. Algeciras-Schimnich, R.J. Singh, J.M. Colón-Franco, J.W. Findling, New Cutoffs for the Biochemical Diagnosis of Adrenal Insufficiency after ACTH Stimulation using Specific Cortisol Assays. J. Endocr. Soc. 5, 1–11 (2021). https://doi.org/10.1210/jendso/bvab022

Article  CAS  Google Scholar 

P. Agnieszka, S. Pearce, Adrenal insufficiency – Recognition and management. Clin. Med. 17, 258–262 (2017). https://doi.org/10.7861/clinmedicine.17-5-480a

Article  Google Scholar 

M. Vogeser, J. Kratzsch, Y. Ju Bae, M. Bruegel, U. Ceglarek, T. Fiers, A. Gaudl, H. Kurka, C. Milczynski, C. Prat Knoll, A.C. Suhr, D. Teupser, I. Zahn, R.E. Ostlund, Multicenter performance evaluation of a second generation cortisol assay. Clin. Chem. Lab Med. 55, 826–835 (2017). https://doi.org/10.1515/cclm-2016-0400

Article  CAS  PubMed  Google Scholar 

J.M. Hawley, L.J. Owen, S.J. Lockhart, P.J. Monaghan, A. Armston, C.A. Chadwick, H. Wilshaw, M. Freire, L. Perry, B.G. Keevil, Serum cortisol: An up-to-date assessment of routine assay performance. Clin. Chem. 62, 1220–1229 (2016). https://doi.org/10.1373/clinchem.2016.255034

Article  CAS  PubMed  Google Scholar 

K. Tordjman, A. Jaffe, Y. Trostanetsky, Y. Greenman, R. Limor, N. Stern, Low-dose (1 μg) adrenocorticotrophin (ACTH) stimulation as a screening test for impaired hypothalamo-pituitary-adrenal axis function: Sensitivity, specificity and accuracy in comparison with the high-dose (250 μg) test. Clin. Endocrinol. 52, 633–640 (2000). https://doi.org/10.1046/j.1365-2265.2000.00984.x

Article  CAS  Google Scholar 

N.S. Ospina, A. Nofal, Al, I. Bancos, A. Javed, K. Benkhadra, E. Kapoor, A.N. Lteif, N. Natt, M.H. Murad, ACTH stimulation tests for the diagnosis of adrenal insufficiency: Systematic review and meta-analysis. J. Clin. Endocrinol. Metab. 101, 427–434 (2016). https://doi.org/10.1210/jc.2015-1700

Article  CAS  PubMed  Google Scholar 

M. Wade, S. Baid, K. Calis, H. Raff, N. Sinaii, L. Nieman, Technical details influence the diagnostic accuracy of the 1 μg ACTH stimulation test. Eur. J. Endocrinol. 162, 109–113 (2010). https://doi.org/10.1530/EJE-09-0746

Article  CAS  PubMed  Google Scholar 

L.G. Mancillas-Adame, A. Sánchez-García, R. Rodriguez-Gutierrez, C. Gonzalez-Velazquez, F.J. Lavalle-Gonzalez, J.A. Zuñiga-Hernandez, A.G. Rios-Ortega, J.G. González-González, Low-Dose ACTH Stimulation Test in Obesity: A Randomized Dose Assessment. Int. J. Endocrinol. 2022, (2022). https://doi.org/10.1155/2022/7860272

I.A. Odeniyi, O.A. Fasanmade, A.O. Ogbera, A.E. Ohwovoriole, Body mass index and its effect on serum cortisol level. Niger. J. Clin. Pr. 18, 194–197 (2015). https://doi.org/10.4103/1119-3077.151040

Article  CAS  Google Scholar 

R. Pasquali, L. Gagliardi, V. Vicennati, A. Gambineri, D. Colitta, L. Ceroni, F. Casimirri, ACTH and cortisol response to combined corticotropin releasing hormone-arginine vasopressin stimulation in obese males and its relationship to body weight, fat distribution and parameters of the metabolic syndrome. Int J. Obes. 23, 419–424 (1999). https://doi.org/10.1038/sj.ijo.0800838

Article  CAS  Google Scholar 

R. Pasquali, S. Cantobelli, F. Casimirri, M. Capelli, L. Bortoluzzi, R. Flamia, A.M.M. Labate, L. Barbara, The hypothalamic-pituitary-adrenal axis in obese women with different patterns of body fat distribution. J. Clin. Endocrinol. Metab. 77, 341–346 (1993). https://doi.org/10.1210/jcem.77.2.8393881

Article  CAS  PubMed  Google Scholar 

I.H. Thorneycroft, D.R. Mishell, S.C. Stone, K.M. Kharma, R.M. Nakamura, The relation of serum 17-hydroxyprogesterone and estradiol-17-beta levels during the human menstrual cycle. Am. J. Obstet. Gynecol. 111, 947–951 (1971). https://doi.org/10.1016/0002-9378(71)90951-3

Article  CAS  PubMed  Google Scholar 

I.Z. Beitins, F. Bayard, A. Kowarski, C.J. Migeon, The effect of ACTH administration on plasma testosterone, dihydrotestosterone and serum LH concentrations in normal men. Steroids 21, 553–563 (1973). https://doi.org/10.1016/0039-128x(73)90044-5

Article  CAS  PubMed  Google Scholar 

M. Vogeser, R. Zachoval, K. Jacob, Serum cortisol/cortisone ratio after Synacthen stimulation. Clin. Biochem. 34, 421–425 (2001). https://doi.org/10.1016/s0009-9120(01)00251-x

Article  CAS  PubMed  Google Scholar 

M. Vogeser, R. Zachoval, T.W. Felbinger, K. Jacob, Increased Ratio of Serum Cortisol to Cortisone in Acute-Phase Response. Horm. Res. 58, 172–175 (2002). https://doi.org/10.1159/000065486

Article  CAS  PubMed  Google Scholar 

E. Boonen, H. Vervenne, P. Meersseman, R. Andrew, L. Mortier, P.E. Declercq, Y.-M. Vanwijngaerden, I. Spriet, P.J. Wouters, S. Vander Perre, L. Langouche, I. Vanhorebeek, B.R. Walker, G. Van den Berghe, Reduced Cortisol Metabolism during Critical Illness. N. Engl. J. Med. 368, 1477–1488 (2013). https://doi.org/10.1056/nejmoa1214969

Article  CAS  PubMed  PubMed Central  Google Scholar 

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