Shared genetic architecture between periodontal disease and type 2 diabetes: a large scale genome-wide cross-trait analysis

B.L. Pihlstrom, B.S. Michalowicz, N.W. Johnson, Periodontal diseases. Lancet 366(9499), 1809–1820 (2005)

Article  PubMed  Google Scholar 

I.L. Chapple, R. Genco; workshop* wgotjEA, Diabetes and periodontal diseases: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. J. Periodontol. 84, S106–S112 (2013)

Article  PubMed  Google Scholar 

C. Tsai, C. Hayes, G.W. Taylor, Glycemic control of type 2 diabetes and severe periodontal disease in the US adult population. Community Dent. oral. Epidemiol. 30(3), 182–192 (2002)

Article  PubMed  Google Scholar 

L. Casanova, F. Hughes, P. Preshaw, Diabetes and periodontal disease: a two-way relationship. Br. Dent. J. 217(8), 433–437 (2014)

Article  CAS  PubMed  Google Scholar 

C.A. Negrato, O. Tarzia, L. Jovanovič, L.E.M. Chinellato, Periodontal disease and diabetes mellitus. J. Appl. Oral. Sci. 21, 1–12 (2013)

Article  CAS  PubMed  PubMed Central  Google Scholar 

A.J. Hartz, D.C. Rupley Jr, R.D. Kalkhoff, A.A. Rimm, Relationship of obesity to diabetes: influence of obesity level and body fat distribution. Preventive Med. 12(2), 351–357 (1983)

Article  CAS  Google Scholar 

T.A.V. Pham, T.T.P. Tran, The interaction among obesity, Type 2 diabetes mellitus, and periodontitis in Vietnamese patients. Clin. Exp. Dent. Res. 4(3), 63–71 (2018)

Article  PubMed  PubMed Central  Google Scholar 

I.-S. Song, K. Han, Y.-M. Park et al. Severe periodontitis is associated with insulin resistance in non-abdominal obese adults. J. Clin. Endocrinol. Metab. 101(11), 4251–4259 (2016)

Article  CAS  PubMed  Google Scholar 

A. Mahajan, D. Taliun, M. Thurner et al. Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. Nat. Genet. 50(11), 1505–1513 (2018)

Article  CAS  PubMed  PubMed Central  Google Scholar 

J. Chen, C.N. Spracklen, G. Marenne et al. The trans-ancestral genomic architecture of glycemic traits. Nat. Genet. 53(6), 840–860 (2021)

Article  CAS  PubMed  PubMed Central  Google Scholar 

A.K. Manning, M.-F. Hivert, R.A. Scott et al. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat. Genet. 44(6), 659–669 (2012)

Article  CAS  PubMed  PubMed Central  Google Scholar 

V. Lagou, R. Mägi, J.-J. Hottenga et al. Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability. Nat. Commun. 12(1), 24 (2021)

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

J. Dupuis, C. Langenberg, I. Prokopenko et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat. Genet. 42(2), 105–116 (2010)

Article  CAS  PubMed  PubMed Central  Google Scholar 

D. Shungin, S. Haworth, K. Divaris et al. Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data. Nat. Commun. 10(1), 2773 (2019)

Article  ADS  PubMed  PubMed Central  Google Scholar 

Q. Lu, B. Li, D. Ou et al. A powerful approach to estimating annotation-stratified genetic covariance via GWAS summary statistics. Am. J. Hum. Genet. 101(6), 939–964 (2017)

Article  CAS  PubMed  PubMed Central  Google Scholar 

B.K. Bulik-Sullivan, P.-R. Loh, H.K. Finucane et al. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat. Genet. 47(3), 291–295 (2015)

Article  CAS  PubMed  PubMed Central  Google Scholar 

B. Bulik-Sullivan, H.K. Finucane, V. Anttila et al. An atlas of genetic correlations across human diseases and traits. Nat. Genet. 47(11), 1236–1241 (2015)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Y. Zhang, Q. Lu, Y. Ye et al. SUPERGNOVA: local genetic correlation analysis reveals heterogeneous etiologic sharing of complex traits. Genome Biol. 22, 1–30 (2021)

Article  Google Scholar 

X. Zhu, T. Feng, B.O. Tayo et al. Meta-analysis of correlated traits via summary statistics from GWASs with an application in hypertension. Am. J. Hum. Genet. 96(1), 21–36 (2015)

Article  CAS  PubMed  PubMed Central  Google Scholar 

S. Purcell, B. Neale, K. Todd-Brown et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81(3), 559–575 (2007)

Article  CAS  PubMed  PubMed Central  Google Scholar 

W. McLaren, L. Gil, S.E. Hunt et al. The ensembl variant effect predictor. Genome Biol. 17(1), 1–14 (2016)

Article  Google Scholar 

Y. Lu, C. Quan, H. Chen, X. Bo, C. Zhang. 3DSNP: a database for linking human noncoding SNPs to their three-dimensional interacting genes. Nucleic Acids Res. 45(D1), D643–D649 (2016)

J.K. Pickrell, T. Berisa, J.Z. Liu, L. Ségurel, J.Y. Tung, D.A. Hinds, Detection and interpretation of shared genetic influences on 42 human traits. Nat. Genet. 48(7), 709–717 (2016)

Article  CAS  PubMed  PubMed Central  Google Scholar 

U. Raudvere, L. Kolberg, I. Kuzmin et al. g: Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update). Nucleic acids Res. 47(W1), W191–W198 (2019)

Article  CAS  PubMed  PubMed Central  Google Scholar 

A. Gusev, A. Ko, H. Shi et al. Integrative approaches for large-scale transcriptome-wide association studies. Nat. Genet. 48(3), 245–252 (2016)

Article  CAS  PubMed  PubMed Central  Google Scholar 

D.A. Lawlor, R.M. Harbord, J.A. Sterne, N. Timpson, G. Davey Smith, Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat. Med. 27(8), 1133–1163 (2008)

Article  MathSciNet  PubMed  Google Scholar 

J. Bowden, G. Davey Smith, P.C. Haycock, S. Burgess, Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator. Genet. Epidemiol. 40(4), 304–314 (2016)

Article  PubMed  PubMed Central  Google Scholar 

J. Bowden, G. Davey Smith, S. Burgess, Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int. J. Epidemiol. 44(2), 512–525 (2015)

Article  PubMed  PubMed Central  Google Scholar 

M. Verbanck, C.-Y. Chen, B. Neale, R. Do, Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat. Genet. 50(5), 693–698 (2018)

Article  CAS  PubMed  PubMed Central  Google Scholar 

J. Bowden, W. Spiller, F. Del Greco M et al. Improving the visualization, interpretation and analysis of two-sample summary data Mendelian randomization via the Radial plot and Radial regression. Int. J. Epidemiol. 47(4), 1264–1278 (2018)

Article  PubMed  PubMed Central  Google Scholar 

G. Hemani, J. Zheng, B. Elsworth et al. The MR-Base platform supports systematic causal inference across the human phenome. elife 7, e34408 (2018)

Article  PubMed  PubMed Central  Google Scholar 

G. Hemani, K. Tilling, G. Davey Smith, Orienting the causal relationship between imprecisely measured traits using GWAS summary data. PLoS Genet. 13(11), e1007081 (2017)

Article  PubMed  PubMed Central  Google Scholar 

J. Dong, Y. Gong, T. Chu et al. Mendelian randomization highlights the causal association of obesity with periodontal diseases. J. Clin. Periodontol. 49(7), 662–671 (2022)

Article  PubMed  Google Scholar 

A.E. Locke, B. Kahali, S.I. Berndt et al. Genetic studies of body mass index yield new insights for obesity biology. Nature 518(7538), 197–206 (2015)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Y.-B. Wang, S.-Y. Yan, X.-H. Li et al. Causal association between periodontitis and type 2 diabetes: A bidirectional two-sample mendelian randomization analysis. Front. Genet. 12, 792396 (2022)

Article  PubMed  PubMed Central  Google Scholar 

Y. Wang, T. Chu, Y. Gong et al. Mendelian randomization supports the causal role of fasting glucose on periodontitis. Front. Endocrinol. 13, 860274 (2022)

Article  Google Scholar 

C.A. Lowell, P. Soriano, Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories. Genes Dev. 10(15), 1845–1857 (1996)

Article  CAS 

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