Introduction Kinesio taping (KT) has been extensively applied in the management of musculoskeletal disorders. Although plentiful systematic reviews (SRs) have evaluated its efficacy, there are no convincing conclusions due to disperse and inconclusive results, and its clinical relevance remains unclear. Hence, there is a need to summarise all the SRs for the comprehensive and consistent evidence. This overview aims to appraise the overall effectiveness of KT in musculoskeletal disorders, and provide evidence maps to visualise the findings. Method and analysis Electronic databases (Cochrane Database of Systematic Reviews, MEDLINE, Embase, Epistemonikos, PEDro, Scopus, ISI Web of Science) and reference lists will be searched from inception to September 2024 for the SRs of randomised controlled trials (RCTs). The SRs involving comparisons of the effectiveness between single or adjunctive KT and other interventions for patients with musculoskeletal disorders will be included. The primary and additional outcome to be considered will be the core outcome set, and the patient-reported outcome measure and patient-important outcome, respectively. Two reviewers will independently screen and select studies, extract the data, and evaluate the reporting and methodological quality of eligible SRs as well as the risk of bias of included RCTs. For the SRs without meta-analysis, we will collate the number of RCTs that showed any differences in outcomes. For the SRs with meta-analysis, we will provide the original summary of evidence (e.g., pooled effects and heterogeneity) for outcomes with an evaluation of missing results and clinical relevance. The certainty of each outcome will be measured, and user-friendly maps of findings will be presented graphically. Ethics and dissemination Formal ethical approval for this study is not required, since the data will be only collected from published literature in public databases. The results will be disseminated in the peer-reviewed academic journal, and relevant datasets will be preserved in the online repository. PROSPERO registration number CRD42024517528

The authors have declared no competing interest.

PROSPERO CRD42024517528

https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024517528

This work was supported by the National Natural Science Foundation of China (No. 82205245), the Natural Science Foundation of Guangdong, China (No. 2023A1515011143), the Science and Technology Program of Guangzhou, China (No. 2023A04J0421), the Teaching quality and teaching reform project of Southern Medical University in 2022 (〔2022〕22), the National College Student Innovation and Entrepreneurship Training Program (No. 202212121048 and 202312121264).

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Electronic databases (Cochrane Database of Systematic Reviews, MEDLINE, Embase, Epistemonikos, PEDro, Scopus, ISI Web of Science, PROSPERO, and OpenGrey)

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