Volume 82, August 2024, 154768Author links open overlay panel, Section snippetsPro- and anti-biotic: can we get along?

We commend the authors on their review of the microbiome in critical illness and agree that associated therapies deserve further attention. The work of Sung et al. [1] raises important questions regarding the certainty of existing data, the role of related interventions such as Selective Digestive Decontamination (SDD), and the framework for advancing this complex field.

The microbiome is a diverse and dynamic system. As little as 30% of its bacterial species may be shared between individuals.

Repositories

Not applicable.

Funding

No funding acknowledgements or financial disclosures.

CRediT authorship contribution statement

Tess Evans: Conceptualization, Data curation, Investigation, Resources, Writing – original draft, Writing – review & editing. Edward Litton: Data curation, Investigation, Writing – review & editing.

Declaration of competing interest

No conflicts of interest.

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T. Evans et al.Lower gut dysbiosis and mortality in acute critical illness: a systematic review and meta-analysis

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D.E. Freedberg et al.Pathogen colonization of the gastrointestinal microbiome at intensive care unit admission and risk for subsequent death or infection

Intensive Care Med

(2018)

S. Schlebusch et al.Standard rectal swabs as a surrogate sample for gut microbiome monitoring in intensive care

BMC Microbiol

(2022)

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