Volume 210, April 2024, Pages 8-14Author links open overlay panel, , , , , , , Abstract

An 11-year-old male Miniature Dachshund dog was presented with dyschezia. Computed tomography examination 35 days after the initial visit revealed a prostate mass (4.0 × 3.5 × 2.7 cm) and prostatectomy and orchiectomy were performed 13 days later. Grossly, the prostate was rubbery and the cut surface of the mass was swollen. The mass was whitish and demarcated from the surrounding tissues. Microscopically, the mass had a capsulate consisting of atypical spindloid stromal cells arranged in a phyllode pattern and also in a fasciculated pattern admixed with acinar ductal cells. Atypical stromal cells contained round-to-oval finely hyperchromatic nuclei that had distinct nuclei and abundant eosinophilic cytoplasm. Immunohistochemically, the atypical stromal cells were positive for vimentin, CD34, desmin, α-smooth muscle actin, progesterone receptor and androgen receptor but negative for cytokeratin AE1/AE3, p63, c-Kit, DOG-1 and SOX10. On the basis of these findings, the tumour was diagnosed as a prostatic stromal tumour of uncertain malignant potential.

Section snippetsFunding

This work was supported by the Japanese Society for the Promotion of Science Grant-in-Aid for Scientific Research (KAKENHI) grant number JP20K06439.

Declaration of competing interests

The authors declared no conflicts of interest in relation to the research, authorship or publication of this article.

References (17)D.E. Hansel et al.Spindle cell lesions of the adult prostate

Mod Pathol

(2007)

Y. Shimoyama et al.Pleomorphic adenoma of the salivary gland in two dogs

J Comp Pathol

(2006)

P.B. Gaudin et al.Sarcomas and related proliferative lesions of specialized prostatic stroma: a clinicopathologic study of 22 cases

Am J Surg Pathol

(1998)

M. Zhou et al.Mesenchymal tumours unique to the prostateD.W. Hayden et al.Prostatic leiomyosarcoma in a dog

J Vet Diagn Invest

(1999)

B. Bacci et al.Primary prostatic leiomyosarcoma with pulmonary metastases in a dog

J Am Anim Hosp Assoc

(2010)

M. Trovatelli et al.Prostatic leiomyosarcoma in a dog treated using a multimodal approach

J Vet Intern Med

(2021)

D. Azakami et al.Establishment and characterization of canine rhabdomyosarcoma cell line CMS-C

J Vet Med

(2011)

There are more references available in the full text version of this article.

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