Available online 7 March 2024, 101411
Author links open overlay panel, , , , , , Highlights•The expression level of EPHX4 was higher in HNSC patients’ tissues.
•EPHX4 expression is closely associated with the immunity of HNSC.
•EPHX4 promotes HNSC cells proliferation, colony formation and invasion.
AbstractObjectivesThe role of Epoxide Hydrolase-4 (EPHX4), a member of epoxide hydrolase family, has not been investigated in cancer. The purpose of this article is to explore the application value of EPHX4 in laryngeal cancer and its relationship with immune infiltration.
MethodsWe observed that EPHX4 expression and its survival assays in laryngeal cancer specimens based on The Cancer Genome Atlas (TCGA) cohorts. We also analyzed the correlation between immune cell infiltration levels and EPHX4 gene copy number in laryngeal cancer. Finally, we conducted in vitro assay to evaluate the functions of EPHX4 in laryngeal cancer cell line.
ResultsEPHX4 is highly expressed in laryngeal cancer specimens and has a poor prognosis. EPHX4 related immune cell analysis showed that it participated in NK Natural killer cell mediated cytotoxicity. Finally, Cell experiments indicate that EPHX4 could promote laryngeal cancer cell line proliferation, colony formation and invasion.
ConclusionsOur research results suggest that EPHX4 may be a potential immunotherapy target for laryngeal cancer. The nominated immune signature is a helpful and promising prognostic indicator in laryngeal cancer.
Levels of EvidenceLevel 3.
KeywordsLaryngeal cancer
EPHX4
Immunotherapeutic
© 2024 Published by Elsevier España, S.L.U. on behalf of Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.
留言 (0)