Objective:This study investigated the effects of ultrasound-guided erector spinal muscle plane block (ESPB) and quadratus muscle block (QLB) on the quality of analgesia and recovery after laparoscopic nephrectomy.Design:randomized, controlled, double-blind study.Setting: A single tertiary care academic medical center,include anesthesia preparation room, operating room, anesthesia recovery room and ward.Patients:Aged 18-70years,ASA grades I-III,elective laparoscopic partial nephrectomy or radical nephrectomy and 54 patients were included in the statistical analysis.Interventions:All included patients were randomassigned to the erector spinal muscle plane block or the quadratus block,and all patients underwent morphine pump controlled analgesia.Results:The study found that ultrasound-guided ESPB had a higher incidence of hypotension than QLB at the T1 time point, but it did not significantly increase the intraoperative dose of the vasoactive drug used. Patients in the ESPB group showed significant improvement in resting NRS pain scores at 0.5h,number of morphine pumps at 6h and 24h, cumulative morphine equivalent consumed 6h after surgery, and QOR-15 score at 24 h after surgery, and shortened hospital stay.Conclusions:Compared with QLB,ESPB has certain advantages in analgesia and recovery quality after laparoscopic nephrectomy, and shows opioid frugality effect at individual postoperative time points.

The authors have declared no competing interest.

Chinese Clinical Trial Registry(ChiCTR2300074743)

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The details of the IRB/oversight body that provided approval or exemption for the research described are given below:

Ethical approval for this study was provided by the Ethics Committee of Sichuan Academy of Medical Sciences, Chengdu, Sichuan (Chairperson Prof Liangping Li) on 19 January 2023, Approval Number: LunShen No.24,2023.

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