Buy Article Permissions and Reprints Abstract

Objective To characterize the relationship between gut microbiota and neonatal acute kidney injury biomarkers based on the gut-kidney axis.

Study Design The Pubmed database was primarily searched to include relevant literature on gut microbiota and neonatal acute kidney injury biomarkers, which was subsequently organized and analyzed and a manuscript was written.

Results Gut microbiota was associated with neonatal acute kidney injury biomarkers. These biomarkers included TIMP-2, IGFBP-7, VEGF, calbindin, GST, B2MG, ghrelin, and clusterin.

Conclusion The gut microbiota is strongly associated with neonatal acute kidney injury biomarkers, and controlling the gut microbiota may be a potential target for ameliorating neonatal acute kidney injury.

Key Points

There is a bidirectional association between gut microbiota and AKI.

Gut microbiota is closely associated with biomarkers of nAKI.

Manipulation of gut microbiota may improve nAKI.

Keywords gut microbiota - neonatal acute kidney injury - gut–kidney axis - biomarkers Authors' Contribution

K.Y. and W.D. designed the manuscript. K.Y. and H.H. collected data for the manuscript. K.Y. wrote the manuscript. K.Y., H.H., and W.D. revised the manuscript. All authors contributed to the manuscript and approved the submitted version.

Publication History

Received: 31 July 2023

Accepted: 30 January 2024

Accepted Manuscript online:
01 February 2024

Article published online:
26 February 2024

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