Prolactinoma is frequently found not only in females but also in males with abnormal reproductive and/or sexual function. Patients typically complain about amenorrhea and infertility because of anovulation. Approximately 15% to 20% of cases of secondary amenorrhea are caused by prolactinemia. Galactorrhea may occur simultaneously, before or after menstrual disorders, and sometimes it may not be clinically obvious, or only detected by breast examination. We reported a case of a 14-year-old girl who presented primary amenorrhea accompanied by frequent headaches and blurred vision. Hormonal tests showed severe hyperprolactinemia (prolactin [PRL] concentration: 1,570 ng/ml). Further tests confirmed a mass in the pituitary with an extension to the left parasellar and suprasellar regions. Some parts of the sella turcica tumor were removed by transcranial surgery. During the follow-up, the clinicopathological examinations revealed the patient had hyperprolactinemia. Clinicians should be aware of the diagnostic and therapeutic problems regarding the management of hyperprolactinemia.

O prolactinoma é frequentemente encontrado não apenas em mulheres, mas também em homens com funç ão reprodutiva e/ou sexual anormal. Os pacientes geralmente se queixam de amenorreia e infertilidade devido à anovulaç ão. Aproximadamente 15% a 20% dos casos de amenorreia secundária são causados por prolactinoma. A galactorreia pode ocorrer simultaneamente, antes ou depois dos distúrbios menstruais, e às vezes pode não ser clinicamente óbvia ou ser detectada apenas pelo exame das mamas. Relatamos o caso de uma menina de 14 anos que apresentou amenorreia primária acompanhada de dores de cabeça frequentes e visão turva. Os testes hormonais mostraram hiperprolactinemia grave (concentraç ão de prolactina [PRL]: 1.570 ng/ml).Outros exames confirmaram uma massa na hipófise com extensão para as regiões parasselar e suprasselar esquerda. Algumas partes do tumor da sela turca foram removidas por cirurgia transcraniana. Durante o acompanhamento, os exames clinicopatológicos revelaram que o paciente apresentava hiperprolactinemia. Os médicos devem estar cientes dos problemas diagnósticos e terapêuticos relativos ao manejo da hiperprolactinemia.

Habibe Sadat Shakeri and Alireza Monemi participated in the conception, design, and interpretation of data; Samaneh Mollazadeh drafted the manuscript; the final version of the manuscript was approved by all authors.

All procedures performed in the study involving human participants were in accordance with the ethical standards of the institutional and/or national research committees and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent was obtained from the patient included in the study.

Received: 06 July 2020

Accepted: 09 March 2021

Article published online:
28 February 2024

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