Guo K, Xiao W, Chen X, Zhao Z, Lin Y, Chen G. Epidemiological trends of head and neck cancer: a population-based study. BioMed Res Int. 2021;2021:1–14. https://doi.org/10.1155/2021/1738932.

Article  Google Scholar 

Chow LQM. Head and neck cancer. N Engl J Med. 2020;382:60–72. https://doi.org/10.1056/NEJMra1715715.

Article  CAS  PubMed  Google Scholar 

Mody MD, Rocco JW, Yom SS, Haddad RI, Saba NF. Head and neck cancer. The Lancet. 2021;398:2289–99. https://doi.org/10.1016/S0140-6736(21)01550-6.

Article  Google Scholar 

Kielbassa AM, Hinkelbein W, Hellwig E, Meyer-Lückel H. Radiation-related damage to dentition. Lancet Oncol. 2006;7:326–35. https://doi.org/10.1016/S1470-2045(06)70658-1.

Article  PubMed  Google Scholar 

Epstein JB, Thariat J, Bensadoun R-J, Barasch A, Murphy BA, Kolnick L, et al. Oral complications of cancer and cancer therapy. CA Cancer J Clin. 2012;62:400–22. https://doi.org/10.3322/caac.21157.

Article  PubMed  Google Scholar 

Baudelet M, Van den Steen L, Tomassen P, Bonte K, Deron P, Huvenne W, et al. Very late xerostomia, dysphagia, and neck fibrosis after head and neck radiotherapy. Head Neck. 2019;41:3594–603. https://doi.org/10.1002/hed.25880.

Article  PubMed  Google Scholar 

Zhang Y, Wang X, Li H, Ni C, Du Z, Yan F. Human oral microbiota and its modulation for oral health. Biomed Pharmacother. 2018;99:883–93. https://doi.org/10.1016/j.biopha.2018.01.146.

Article  PubMed  Google Scholar 

Kassebaum NJ, Bernabé E, Dahiya M, Bhandari B, Murray CJL, Marcenes W. Global burden of untreated caries: a systematic review and metaregression. J Dent Res. 2015;94:650–8. https://doi.org/10.1177/0022034515573272.

Article  CAS  PubMed  Google Scholar 

World Health Organization. Sugar and dental caries 2017. https://www.who.int/news-room/fact-sheets/detail/sugars-and-dental-caries. Accessed 23 May 2023.

World Health Organization. Global oral health status report 2022. https://www.who.int/team/noncommunicable-diseases/global-status-report-on-oral-health-2022. Accessed 23 May 2023.

Peng X, Cheng L, You Y, Tang C, Ren B, Li Y, et al. Oral microbiota in human systematic diseases. Int J Oral Sci. 2022;14:14. https://doi.org/10.1038/s41368-022-00163-7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

• Niazi SA, Bakhsh A. Association between endodontic infection, its treatment and systemic health: a narrative review. Med Kaunas Lith. 2022;58:931. https://doi.org/10.3390/medicina58070931. This review highlights the systemic impact of infections resulting from dental caries. It describes the potential role of dental-associated bacteremia and low-grade systemic inflammation in the development of cardiovascular disease, adverse pregnancy outcomes and metabolic dyscontrol in diabetes. It provides essential information on the links between oral health and systemic health.

Article  Google Scholar 

Segura-Egea JJ, Martín-González J, Castellanos-Cosano L. Endodontic medicine: connections between apical periodontitis and systemic diseases. Int Endod J. 2015;48:933–51. https://doi.org/10.1111/iej.12507.

Article  CAS  PubMed  Google Scholar 

Guo A, Wide U, Arvidsson L, Eiben G, Hakeberg M. Dietary intake and meal patterns among young adults with high caries activity: a cross-sectional study. BMC Oral Health. 2022;22:1–9. https://doi.org/10.1186/s12903-022-02227-w.

Article  CAS  Google Scholar 

Reis Ferreira M, Pasto A, Ng T, Patel V, Guerrero Urbano T, Sears C, et al. The microbiota and radiotherapy for head and neck cancer: what should clinical oncologists know? Cancer Treat Rev. 2022;109:102442. https://doi.org/10.1016/j.ctrv.2022.102442.

Article  PubMed  Google Scholar 

• Bruno JS, Al-Qadami GH, Laheij AMGA, Bossi P, Fregnani ER, Wardill HR. From pathogenesis to intervention: the importance of the microbiome in oral mucositis. Int J Mol Sci. 2023;24:8274. https://doi.org/10.3390/ijms24098274. This work explores the intricacies between the oral and gut microbiome and the development of oral mucositis (OM) associated with cancer therapy. Authors explore the emerging role of a patient’s microbial fingerprint in OM development and prediction. This is an interesting aspect of the links between oral health and cancer.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu X-X, Yang X-J, Chao Y-L, Zheng H-M, Sheng H-F, Liu H-Y, et al. The potential effect of oral microbiota in the prediction of mucositis during radiotherapy for nasopharyngeal carcinoma. EBioMedicine. 2017;18:23–31. https://doi.org/10.1016/j.ebiom.2017.02.002.

Article  PubMed  PubMed Central  Google Scholar 

Jiang R, Liu Y, Zhang H, Chen Y, Liu T, Zeng J, et al. Distinctive microbiota of delayed healing of oral mucositis after radiotherapy of nasopharyngeal carcinoma. Front Cell Infect Microbiol 2022;12. https://doi.org/10.3389/fcimb.2022.1070322.

Jasmer KJ, Gilman KE, Muñoz Forti K, Weisman GA, Limesand KH. Radiation-induced salivary gland dysfunction: mechanisms, therapeutics and future directions. J Clin Med. 2020;9:4095. https://doi.org/10.3390/jcm9124095.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dreizen S, Brown LR, Handler S, Levy BM. Radiation-induced xerostomia in cancer patients. Effect on salivary and serum electrolytes. Cancer 1976;38:273–8. https://doi.org/10.1002/1097-0142(197607)38:1<273::aid-cncr2820380141>3.0.co;2-8.

• Muñoz MA, Garín-Correa C, González-Arriagada W, Quintela Davila X, Häberle P, Bedran-Russo A, et al. The adverse effects of radiotherapy on the structure of dental hard tissues and longevity of dental restoration. Int J Radiat Biol. 2020;96:910–8. https://doi.org/10.1080/09553002.2020.1741718. This in vitro study explores: (i) the structural alterations of enamel and dentin; and (ii) the influence on the bonding strength stability after ionizing radiation from 0 to 70Gy. It provides essential biological data to offer targeted oral treatment to HNC patients.

Article  CAS  PubMed  Google Scholar 

•• Douchy L, Gauthier R, Abouelleil-Sayed H, Colon P, Grosgogeat B, Bosco J. The effect of therapeutic radiation on dental enamel and dentin: a systematic review. Dent Mater. 2022;38:e181-201. https://doi.org/10.1016/j.dental.2022.04.014. This systematic review explores the tissular changes induced by radiotherapy in teeth. It provides essential biological data to offer targeted oral treatment to HNC patients.

Article  CAS  PubMed  Google Scholar 

Martini GR, Bortoluzzi EA, Minamisako MC, Bordignon NCT, Rodrigues PM, Gondak R. Impact of radiotherapy on the morphological and compositional structure of intra-radicular dentin. Braz Dent J n.d.;34:45–51. https://doi.org/10.1590/0103-6440202305101.

Eggmann F, Hwang JD, Ayub JM, Mante FK. Impact of irradiation on the adhesive performance of resin-based dental biomaterials: a systematic review of laboratory studies. Materials. 2023;16:2580. https://doi.org/10.3390/ma16072580.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Poyton HG. The effects of radiation on teeth. Oral Surg Oral Med Oral Pathol. 1968;26:639–46. https://doi.org/10.1016/0030-4220(68)90430-1.

Article  CAS  PubMed  Google Scholar 

Palmier NR, Ribeiro ACP, Fonsêca JM, Salvajoli JV, Vargas PA, Lopes MA, et al. Radiation-related caries assessment through the International Caries Detection and Assessment System and the Post-Radiation Dental Index. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;124:542–7. https://doi.org/10.1016/j.oooo.2017.08.019.

Article  PubMed  Google Scholar 

Hajishengallis G. Interconnection of periodontal disease and comorbidities: evidence, mechanisms, and implications. Periodontol. 2000;2022(89):9–18. https://doi.org/10.1111/prd.12430.

Article  Google Scholar 

Kalhan AC, Wong ML, Allen F, Gao X. Periodontal disease and systemic health: an update for medical practitioners. Ann Acad Med Singapore. 2022;51:567–74. https://doi.org/10.47102/annals-acadmedsg.2021503.

Article  PubMed  Google Scholar 

Sedghi LM, Bacino M, Kapila YL. Periodontal disease: the good, the bad, and the unknown. Front Cell Infect Microbiol. 2021;11:766944. https://doi.org/10.3389/fcimb.2021.766944.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bahig H, Fuller CD, Mitra A, Yoshida-Court K, Solley T, Ping Ng S, et al. Longitudinal characterization of the tumoral microbiome during radiotherapy in HPV-associated oropharynx cancer. Clin Transl Radiat Oncol. 2021;26:98–103. https://doi.org/10.1016/j.ctro.2020.11.007.

Article  CAS  PubMed  Google Scholar 

Hoare A, Wang H, Meethil A, Abusleme L, Hong B-Y, Moutsopoulos NM, et al. A cross-species interaction with a symbiotic commensal enables cell-density-dependent growth and in vivo virulence of an oral pathogen. ISME J. 2021;15:1490–504. https://doi.org/10.1038/s41396-020-00865-y.

Article  CAS  PubMed  Google Scholar 

Xanthinaki A, Nicolatou-Galitis O, Athanassiadou P, Gonidi M, Kouloulias V, Sotiropoulou-Lontou A, et al. Apoptotic and inflammation markers in oral mucositis in head and neck cancer patients receiving radiotherapy: preliminary report. Support Care Cancer. 2008;16:1025–33. https://doi.org/10.1007/s00520-007-0379-8.

Article  PubMed  Google Scholar 

Bossi P, Bergamini C, Miceli R, Cova A, Orlandi E, Resteghini C, et al. Salivary cytokine levels and oral mucositis in head and neck cancer patients treated with chemotherapy and radiation therapy. Int J Radiat Oncol. 2016;96:959–66. https://doi.org/10.1016/j.ijrobp.2016.08.047.

Article  CAS  Google Scholar 

Liu X, Li H. A systematic review and meta-analysis on multiple cytokine gene polymorphisms in the pathogenesis of periodontitis. Front Immunol. 2021;12:713198. https://doi.org/10.3389/fimmu.2021.713198.

Article  CAS  PubMed  Google Scholar 

Takenaka Y, Cho H, Yamamoto M, Nakahara S, Yamamoto Y, Inohara H. Incidence and predictors of febrile neutropenia during chemotherapy in patients with head and neck cancer. Support Care Cancer. 2013;21:2861–8. https://doi.org/10.1007/s00520-013-1873-9.

Article  PubMed  Google Scholar 

Kitaya S, Kakuta R, Kanamori H, Ohkoshi A, Ishii R, Nomura K, et al. Clinical and epidemiological characteristics of bloodstream infections in head and neck cancer patients: a decadal observational study. J Clin Med. 2022;11:4820. https://doi.org/10.3390/jcm11164820.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu J, Yang G, An W, Wang W, Li F, Meng Y, et al. Correlations between the severity of radiation-induced oral mucositis and salivary epidermal growth factor as well as inflammatory cytokines in patients with head and neck cancer. Head Neck. 2023;45:1122–9. https://doi.org/10.1002/hed.27313.

Article  PubMed