Survival differences in non-seminoma testis cancer patients according to race/ethnicity

A large historical population-based analysis suggested that non-Caucasian race may predispose to higher cancer-specific mortality (CSM) in non-seminoma testis cancer patients [1]. However, previous analyses did not address and did not report, whether differences in CSM specifically applied to one select subgroup of non-Caucasians (Hispanics, Asians/Pacific Islanders and African-Americans) or applied non-selectively to all non-Caucasians. Specifically, it is not known whether higher CSM in non-Caucasians applies to Hispanics, Asians/Pacific Islanders (Asians) and/or African-Americans or all of the above groups. Moreover, it is not known what is the magnitude of CSM-increase relative to Caucasians, in each of the three above race/ethnicity groups. Finally, it is unknown whether higher CSM within each of the three above race/ethnicity groups applies the same or differently across all stages (I vs. II vs. III). We addressed these knowledge gaps and hypothesized that race/ethnicity other than Caucasian indeed adversely affects CSM in all assessable race/ethnicity groups other than Caucasians. Moreover, we hypothesized that the magnitude of that effect is similar across the three race/ethnicity groups and is equally applicable in all three stages (stage I, stage II, stage III). We tested these hypotheses relying on the Surveillance, Epidemiology, and End Results (SEER) database (2004 −2019).

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