Cytokines and Pentraxin 3 Levels in Unexplained Recurrent Pregnancy Loss: Role of Oral Micronized Progesterone Therapy as Immunomodulator on Their Levels and Pregnancy Outcome, a Prospective Comparative Study

Jaslow CR, Carney JL, Kutteh WH. Diagnostic factors identified in 1020 women with two versus three or more recurrent pregnancy losses. Fertil Steril. 2010;93(4):1234–43.

Article  CAS  PubMed  Google Scholar 

Yui J, Garcia-Lloret M, Wegmann TG, Guilbert LJ. Cytotoxicity of tumor necrosis factor-alpha and gamma-interferon against primary human placental trophoblasts. Placenta. 1994;15(8):819–35.

Article  CAS  PubMed  Google Scholar 

Doni A, Mantovani G, Porta C, et al. Cell specific regulation of PTX3 by glucocorticoid hormones in hematopoietic and nonhematopoietic cells. J Biol Chem. 2008;283(44):29983–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choi BC, Polgar K, Xiao L, Hill JA. Progesterone inhibits in-vitro embryotoxic Thl cytokine production to trophoblast in women with recurrent pregnancy loss. Hum Reprod. 2000;15(1):46–59.

Article  CAS  PubMed  Google Scholar 

Raghupathy R, Al-Mutawa E, Al-Azemi M, et al. Progesterone-induced blocking (PIBF) modulates cytokine production by lymphocytes from women with recurrent miscarriage or preterm delivery. J Reprod Immunol. 2009;80(1):91–9.

Article  CAS  PubMed  Google Scholar 

Daher S, de Arruda Geraldes-Denardi K, Blotta MH, et al. Cytokines in recurrent pregnancy loss. J Reprod Immunol. 2004;62:151–7.

Article  CAS  PubMed  Google Scholar 

Pietrowski D, Bettendorf H, Keck C, et al. Lack of association of TNFalpha gene polymorphisms and recurrent pregnancy loss in Caucasian women. J Reprod Immunol. 2004;61(1):51–8.

Article  CAS  PubMed  Google Scholar 

Kumar A, Begum N, Prasad S, Aggarwal S, Sharma S. Oral dydrogesterone treatment during early pregnancy to prevent recurrent pregnancy loss and its role in modulation of cytokine production: a double-blind, randomized, parallel, placebo-controlled trial. Fertil Steril. 2014;102(5):1357-1363.e3.

Article  CAS  PubMed  Google Scholar 

Ismail AM, Agban MN, Hasanein AS, Rayan AA, Abbas AM. Role of Th-1 cell cytokines, leukemia inhibitory factor and hoxA genes in women with recurrent pregnancy loss. Middle East Fertil Society J. 2017;22(4):300–4.

Article  Google Scholar 

Talukdar A, Rai R, Sharma KA, Rao DN, Sharma A. Peripheral Gamma Delta T cells secrete inflammatory cytokines in women with idiopathic recurrent pregnancy loss. Cytokine. 2018;102:117–22.

Article  CAS  PubMed  Google Scholar 

Ali S, Mazid S, Ali MN, Taing S, Rehman MU, Arafah A. Cytokine imbalance at materno-embryonic interface as a potential immune mechanism for recurrent pregnancy loss. Int Immunopharmacol. 2021;90: 107118.

Article  CAS  PubMed  Google Scholar 

Ibrahim MI, Harb HM, Ellaithy MI, Elkabarity RH, Abdelgwad MH. First trimester assessment of pentraxin-3 levels in women with primary unexplained recurrent pregnancy loss. Eur J Obstet Gynecol Reprod Biol. 2012;165(1):37–41.

Article  CAS  PubMed  Google Scholar 

Zeybek S, Tepeli E, Cetin GO, et al. Increased expression of Pentraxin 3 in placental tissue from patients with unexplained recurrent pregnancy loss. Balkan J Med Genet. 2019;22(1):21–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Larsson A, Palm M, Helmersson J, Axelsson O. Pentraxin 3 values during normal pregnancy. Inflammation. 2011;34(5):448–51.

Article  CAS  PubMed  Google Scholar 

Hussain GA, Azizieh F, Makhseed M, Raghupathy R. Effects of progesterone dydrogesterone and estrogen on the production of TH1/TH2/Th17 cytokines by lymphocytes from women with recurrent spontaneous miscarriage. J Reprod Immumol. 2020;140: 103132.

Article  Google Scholar 

Coomarasamy A, Williams H, Truchanowicz E, et al. A randomized trial of progesterone in women with recurrent miscarriages. N Engl J Med. 2015;373(22):2141–8.

Article  CAS  PubMed  Google Scholar 

Makhseed M, Raghupathy R, Azizieh F, Farhat R, Hassan N, Bandar A. Circulating cytokines and CD30 in normal human pregnancy and recurrent spontaneous abortions. Hum Reprod. 2000;15(9):2011–7.

Article  CAS  PubMed  Google Scholar 

Russu M, Stanculescu R, Paun M, Marin JA. Neonatal outcomes after preconceptional vaginal micronized progesterone administration in recurrent pregnancy loss: five years prospective study. Donald School J Ultras Obstetr Gynecol. 2014;8(2):128–33.

Article  Google Scholar 

留言 (0)

沒有登入
gif