Authors Ufaque Batool K Samo Department of Physiology, Basic Medical Science Institute (BMSI), Jinnah Postgraduate Medical Center, Karachi Kausar Abbas Saldera Department of Physiology, Basic Medical Science Institute (BMSI), Jinnah Postgraduate Medical Center Rizwan Ali Lakho Department of Urology, Sindh Institute of Urology and Transplantation Gul Mohammad Kazi Department of General Surgery, Jinnah Postgraduate Medical Center, Karachi Maliha Shamim Department of Physiology, Basic Medical Science Institute (BMSI), Jinnah Postgraduate Medical Center Sarah Hussain Sharif Department of Internal Medicine, Central Government Dispensaries, Border Health Services-Pakistan. Keywords: Diet, Unhealthy, Trans Fats, Lipids, Infertility Abstract

Objective: To evaluate the effect of dietary trans-unsaturated fatty acids (TFAs) on ovulatory infertility in young unmarried females.
Methods: This cross-sectional study was conducted from 1 august 2023 to 31 December 2023 at the Basic Medical Science Institute (BMSI), Jinnah Postgraduate Medical Center Karachi. All healthy unmarried females aged 15-25 were included in the study. Females with a family history of infertility, having existing comorbidity, history of irregular menstruation cycle or hormonal replacement therapy, were excluded. Based on the Food frequency questionnaire score, 300 subjects were divided into 3 groups, Group A were low trans fats Consumers (Score 0-170), Group B was moderate trans fats consumers
(Score 171-340) and Group C were high trans fats consumers (Score 341-500). The analysis of results was carried out on SPSS Software version 22.
Results: The study’s 300 respondents, who ranged in age from 16 to 25, had a mean age of 21.8 years. Fifteen per cent of those in group “A” had abnormal HDL, 22% had bad LDL, and 23% had abnormal TGA, while 17% had abnormal cholesterol. An abnormal TGA, abnormal HDL, abnormal LDL, and abnormal 31% of the participants in group “B” exhibited abnormal cholesterol levels. A significant correlation between oxidative stress and hormonal indicators was found in three groups: “A” (13%) had aberrant LH, “20%” had abnormal FSH, “11%” had abnormal serum estrogen, “10%” had abnormal serum progesterone, and “C” (49% had abnormal LH, FSH, estrogen, and progesterone). Food frequency questionnaire (FFQ ) scores had a 25% positive correlation with cholesterol, a 40% negative correlation with HDL, a 31% positive correlation with LDL, and a 39% positive correlation with biochemical and hormonal indicators.
Conclusion: Trans fats diets significantly increase the risk of ovulatory infertility and reproductive failure in young females

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