Background: Parkinson’s disease (PD) is a common movement disorder characterized by bradykinesia, rigidity, and resting tremors. Fatigue is a common disabling symptom but is easily ignored in PD. Half of the PD patients were influenced by fatigue. Acupuncture is one of the conservative treatments for fatigue related to other conditions, especially in China. Therefore, we perform a systematic review and meta-analysis to evaluate the evidence for acupuncture’s effectiveness, safety, and cost benefits for the treatment. Methods: This protocol is based on the previously published randomized controlled trial (RCT) studies. A literature search will be performed on the following database: PubMed, the Cochrane Library, Chinese BioMedical Literature Database, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), and Wanfang Data. According to the Cochrane Risk of Bias Tool and the level of evidence for results, we will assess the quality of the included studies by using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) method. The Review Manager (v5.3) software will be applied to statistical analysis.   Results: From the study, we will assess the effectiveness, safety, and cost-benefit of acupuncture on fatigue relief and functional improvement in patients with Parkinson’s Disease.

The authors have declared no competing interest.

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I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).

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No datasets were generated or analysed during the current study. All relevant data from this study will be made available upon study completion.