Oana Irina Gavril, Carmen Camelia Buruiana, Ionela Grosu Creanga, Radu Sebastian Gavril, Irina Mihaela Esanu

ABSTRACT

Hepatic fibrosis is a common consequence of chronic liver diseases and necessitates accurate evaluation for optimal patient management. Traditional liver biopsy, the gold standard for fibrosis assessment, is invasive and can be associated with complications. Lately, considerable progress has been made in developing noninvasive markers for liver fibrosis evaluation.This comprehensive review presents a systematic analysis of the current noninvasive markers for hepatic fibrosis assessment. Serological markers, imaging techniques and novel technologies are thoroughly evaluated for their diagnostic accuracy and clinical applicability.The advantages and limitations of each noninvasive marker are discussed, highlighting their potential to replace or complement liver biopsy. Moreover, challenges and opportunities in standardization, validation, and clinical implementation of these markers are addressed.In conclusion, noninvasive markers play a significant role in hepatic fibrosis evaluation. As reliable alternatives to liver biopsy, these markers have the potential to enhance patient care, streamline disease monitoring, and drive personalized treatment strategies in liver diseases associated with fibrosis. However, further research and validation studies are required to establish their widespread use in routine clinical practice.