Llovet JM, Castet F, Heikenwalder M, Maini MK, Mazzaferro V, Pinato DJ, et al. Immunotherapies for hepatocellular carcinoma. Nat Rev Clin Oncol. 2022;19:151–72. https://doi.org/10.1038/s41571-021-00573-2.
Article CAS PubMed Google Scholar
Makker V, Colombo N, Casado Herraez A, Santin AD, Colomba E, Miller DS, et al. Lenvatinib plus Pembrolizumab for advanced endometrial cancer. N Engl J Med. 2022;386:437–48. https://doi.org/10.1056/NEJMoa2108330.
Article CAS PubMed Google Scholar
Labani-Motlagh A, Ashja-Mahdavi M, Loskog A. The tumor microenvironment: A Milieu hindering and obstructing antitumor immune responses. Front Immunol. 2020;11:940 https://doi.org/10.3389/fimmu.2020.00940.
Article CAS PubMed PubMed Central Google Scholar
Fukumura D, Kloepper J, Amoozgar Z, Duda DG, Jain RK. Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges. Nat Rev Clin Oncol. 2018;15:325–40. https://doi.org/10.1038/nrclinonc.2018.29.
Article CAS PubMed PubMed Central Google Scholar
Pottekat A, Menon AK. Subcellular localization and targeting of N-acetylglucosaminyl phosphatidylinositol de-N-acetylase, the second enzyme in the glycosylphosphatidylinositol biosynthetic pathway. J Biol Chem. 2004;279:15743–51. https://doi.org/10.1074/jbc.M313537200.
Article CAS PubMed Google Scholar
Wang X, Liu R, Zhu W, Chu H, Yu H, Wei P, et al. UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis. Nature. 2019;571:127–31. https://doi.org/10.1038/s41586-019-1340-y.
Article CAS PubMed Google Scholar
Yang W, Xia Y, Ji H, Zheng Y, Liang J, Huang W, et al. Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation. Nature. 2011;480:118–22. https://doi.org/10.1038/nature10598.
Article CAS PubMed PubMed Central Google Scholar
Liang C, Shi S, Qin Y, Meng Q, Hua J, Hu Q, et al. Localisation of PGK1 determines metabolic phenotype to balance metastasis and proliferation in patients with SMAD4-negative pancreatic cancer. Gut. 2020;69:888–900. https://doi.org/10.1136/gutjnl-2018-317163.
Article CAS PubMed Google Scholar
Dang CV. MYC on the path to cancer. Cell. 2012;149:22–35. https://doi.org/10.1016/j.cell.2012.03.003.
Article CAS PubMed PubMed Central Google Scholar
Dang CV. c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol Cell Biol. 1999;19:1–11. https://doi.org/10.1128/MCB.19.1.1.
Article CAS PubMed PubMed Central Google Scholar
Morrison-Smith CD, Knox TM, Filic I, Soroko KM, Eschle BK, Wilkens MK, et al. Combined targeting of the BRD4-NUT-p300 axis in NUT Midline carcinoma by dual selective Bromodomain inhibitor, NEO2734. Mol Cancer Ther. 2020;19:1406–14. https://doi.org/10.1158/1535-7163.MCT-20-0087.
Article CAS PubMed Google Scholar
Patel MC, Debrosse M, Smith M, Dey A, Huynh W, Sarai N, et al. BRD4 coordinates recruitment of pause release factor P-TEFb and the pausing complex NELF/DSIF to regulate transcription elongation of interferon-stimulated genes. Mol Cell Biol. 2013;33:2497–507. https://doi.org/10.1128/MCB.01180-12.
Article CAS PubMed PubMed Central Google Scholar
Muhar M, Ebert A, Neumann T, Umkehrer C, Jude J, Wieshofer C, et al. SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis. Science. 2018;360:800–5. https://doi.org/10.1126/science.aao2793.
Article CAS PubMed PubMed Central Google Scholar
Dang CV, Reddy EP, Shokat KM, Soucek L. Drugging the ‘undruggable’ cancer targets. Nat Rev Cancer. 2017;17:502–8. https://doi.org/10.1038/nrc.2017.36.
Article CAS PubMed PubMed Central Google Scholar
Chen H, Liu H, Qing G. Targeting oncogenic Myc as a strategy for cancer treatment. Signal Transduct Target Ther. 2018;3:5 https://doi.org/10.1038/s41392-018-0008-7.
Article CAS PubMed PubMed Central Google Scholar
Llombart V, Mansour MR. Therapeutic targeting of “undruggable” MYC. EBioMedicine. 2022;75:103756 https://doi.org/10.1016/j.ebiom.2021.103756.
Article CAS PubMed Google Scholar
Scharping NE, Menk AV, Moreci RS, Whetstone RD, Dadey RE, Watkins SC, et al. The tumor microenvironment represses T cell mitochondrial biogenesis to drive intratumoral T Cell metabolic insufficiency and dysfunction. Immunity. 2016;45:374–88. https://doi.org/10.1016/j.immuni.2016.07.009.
Article CAS PubMed PubMed Central Google Scholar
Gutzmer R, Stroyakovskiy D, Gogas H, Robert C, Lewis K, Protsenko S, et al. Atezolizumab, vemurafenib, and cobimetinib as first-line treatment for unresectable advanced BRAF(V600) mutation-positive melanoma (IMspire150): Primary analysis of the randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2020;395:1835–44. https://doi.org/10.1016/S0140-6736(20)30934-X.
Article CAS PubMed Google Scholar
Rodell CB, Arlauckas SP, Cuccarese MF, Garris CS, Li R, Ahmed MS, et al. TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy. Nat Biomed Eng. 2018;2:578–88. https://doi.org/10.1038/s41551-018-0236-8.
Article CAS PubMed PubMed Central Google Scholar
Zhu Y, Yang J, Xu D, Gao XM, Zhang Z, Hsu JL, et al. Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade. Gut. 2019;68:1653–66. https://doi.org/10.1136/gutjnl-2019-318419.
Article CAS PubMed Google Scholar
Xu D, Shao F, Bian X, Meng Y, Liang T, Lu Z. The evolving landscape of noncanonical functions of metabolic enzymes in cancer and other pathologies. Cell Metab. 2021;33:33–50. https://doi.org/10.1016/j.cmet.2020.12.015.
Article CAS PubMed Google Scholar
Luo W, Hu H, Chang R, Zhong J, Knabel M, O'Meally R, et al. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell. 2011;145:732–44. https://doi.org/10.1016/j.cell.2011.03.054.
Article CAS PubMed PubMed Central Google Scholar
Rahl PB, Young RA. MYC and transcription elongation. Cold Spring Harb Perspect Med. 2014;4:a020990 https://doi.org/10.1101/cshperspect.a020990.
Article CAS PubMed PubMed Central Google Scholar
Durbin AD, Zimmerman MW, Dharia NV, Abraham BJ, Iniguez AB, Weichert-Leahey N, et al. Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry. Nat Genet. 2018;50:1240–6. https://doi.org/10.1038/s41588-018-0191-z.
Article CAS PubMed PubMed Central Google Scholar
Schoenfelder S, Fraser P. Long-range enhancer-promoter contacts in gene expression control. Nat Rev Genet. 2019;20:437–55. https://doi.org/10.1038/s41576-019-0128-0.
Article CAS PubMed Google Scholar
Morton AR, Dogan-Artun N, Faber ZJ, MacLeod G, Bartels CF, Piazza MS, et al. Functional enhancers shape extrachromosomal oncogene amplifications. Cell. 2019;179:1330–1341 e1313. https://doi.org/10.1016/j.cell.2019.10.039.
Article CAS PubMed PubMed Central Google Scholar
Alekseyenko AA, Walsh EM, Wang X, Grayson AR, Hsi PT, Kharchenko PV, et al. The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains. Genes Dev. 2015;29:1507–23. https://doi.org/10.1101/gad.267583.115.
Article CAS PubMed PubMed Central Google Scholar
Roussos ET, Condeelis JS, Patsialou A. Chemotaxis in cancer. Nat Rev Cancer. 2011;11:573–87. https://doi.org/10.1038/nrc3078.
Article CAS PubMed PubMed Central Google Scholar
Sahin H, Trautwein C, Wasmuth HE. Functional role of chemokines in liver disease models. Nat Rev Gastroenterol Hepatol. 2010;7:682–90. https://doi.org/10.1038/nrgastro.2010.168.
Article CAS PubMed Google Scholar
Mandrekar P, Ambade A, Lim A, Szabo G, Catalano D. An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: regulation of proinflammatory cytokines and hepatic steatosis in mice. Hepatology. 2011;54:2185–97. https://doi.org/10.1002/hep.24599.
Article CAS PubMed Google Scholar
Zhang J, Patel L, Pienta KJ. Targeting chemokine (C-C motif) ligand 2 (CCL2) as an example of translation of cancer molecular biology to the clinic. Prog Mol Biol Transl Sci. 2010;95:31–53. https://doi.org/10.1016/B978-0-12-385071-3.00003-4.
Article CAS PubMed PubMed Central Google Scholar
Qian BZ, Li J, Zhang H, Kitamura T, Zhang J, Campion LR, et al. CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature. 2011;475:222–5. https://doi.org/10.1038/nature10138.
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