Rubiano A, Carney N, Chesnut R, Puyana J (2015) Global neurotrauma research challenges and opportunities. Nature 527:S193-197. https://doi.org/10.1038/nature16035

Article  CAS  PubMed  Google Scholar 

Davceva N, Janevska V, Ilievski B, Jovanovic R (2012) The importance of the detail forensic-neuropathological examination in the determination of the diffuse brain injuries. Soud Lek 57:2–6

CAS  PubMed  Google Scholar 

Werner C, Engelhard K (2007) Pathophysiology of traumatic brain injury. Br J Anaesth 99:4–9. https://doi.org/10.1093/bja/aem131

Article  CAS  PubMed  Google Scholar 

Kou Z, Gattu R, Kobeissy F et al (2013) Combining biochemical and imaging markers to improve diagnosis and characterization of mild traumatic brain injury in the acute setting: results from a pilot study. PLoS One 8:e80296. https://doi.org/10.1371/journal.pone.0080296

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mckee A, Daneshvar D (2015) The neuropathology of traumatic brain injury. Handb Clin Neurol 127:45–66. https://doi.org/10.1016/B978-0-444-52892-6.00004-0

Article  PubMed  PubMed Central  Google Scholar 

Carpenter K, Czosnyka M, Jalloh I et al (2015) Systemic, local, and imaging biomarkers of brain injury: more needed, and better use of those already established? Front Neurol 6:26. https://doi.org/10.3389/fneur.2015.00026

Article  PubMed  PubMed Central  Google Scholar 

Dadas A, Washington J, Diaz-Arrastia R, Janigro D (2018) Biomarkers in traumatic brain injury (TBI): a review. Neuropsychiatr Dis Treat 14:2989–3000. https://doi.org/10.2147/NDT.S125620

Article  CAS  PubMed  PubMed Central  Google Scholar 

Czeiter E, Amrein K, Gravesteijn B et al (2020) CENTER-TBI Participants and Investigators. Blood biomarkers on admission in acute traumatic brain injury: Relations to severity, CT findings and care path in the CENTER-TBI study. EBioMedicine 56:102785. https://doi.org/10.1016/j.ebiom.2020.102785

Article  PubMed  PubMed Central  Google Scholar 

Zetterberg H, Smith D, Blennow K (2013) Biomarkers of mild traumatic brain injury in cerebrospinal fluid and blood. Nat Rev Neurol 9:201–210. https://doi.org/10.1038/nrneurol.2013.9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Geremia N, Pettersson L, Hasmatali J, Hryciw T, Danielsen N, Schreyer D, Verge V (2010) Endogenous BDNF regulates induction of intrinsic neuronal growth programs in injured sensory neurons. Exp Neurol 223:128–142. https://doi.org/10.1016/j.expneurol.2009.07.022

Article  CAS  PubMed  Google Scholar 

Walder B, Robin X, Rebetez M, Copin J, Gasche Y, Sanchez J, Turck N (2013) The prognostic significance of the serum biomarker heart-fatty acidic binding protein in comparison with s100b in severe traumatic brain injury. J Neurotrauma 30:1631–1637. https://doi.org/10.1089/neu.2012.2791

Article  PubMed  Google Scholar 

Pelinka L, Kroepfl A, Leixnering M, Buchinger W, Raabe A, Redl H (2004) GFAP versus S100B in serum after traumatic brain injury: relationship to brain damage and outcome. J Neurotrauma 21:1553–1561. https://doi.org/10.1089/neu.2004.21.1553

Article  PubMed  Google Scholar 

Yokobori S, Hosein K, Burks S, Sharma I, Gajavelli S, Bullock R (2013) Biomarkers for the clinical differential diagnosis in traumatic brain injury-a systematic review. CNS Neurosci Ther 19:556–565. https://doi.org/10.1111/cns.12127

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mukherjee A, Vogt R, Linthicum D (1985) Measurement of myelin basic protein by radioimmunoassay in closed head trauma, multiple sclerosis and other neurological diseases. Clin Biochem 18:304–307. https://doi.org/10.1016/s0009-9120(85)80037-0

Article  CAS  PubMed  Google Scholar 

Mehta T, Fayyaz M, Giler G et al (2020) Current trends in biomarkers for traumatic brain injury. Open Access J Neurol Neurosurg 12:86–94

PubMed  PubMed Central  Google Scholar 

Failla M, Conley Y, Wagner A (2016) Brain-derived neurotrophic factor (BDNF) in traumatic brain injury-related mortality: interrelationships between genetics and acute systemic and central nervous system BDNF profiles. Neurorehabil Neural Repair 30:83–93. https://doi.org/10.1177/1545968315586465

Article  PubMed  Google Scholar 

Song M, Martinowich K, Lee F (2017) BDNF at the synapse: why location matters. Mol Psychiatry 22:1370–1375. https://doi.org/10.1038/mp.2017.144

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ventriglia M, Zanardini R, Bonomini C et al (2013) Serum brain-derived neurotrophic factor levels in different neurological diseases. Biomed Res Int. 2013:901082. https://doi.org/10.1155/2013/901082

Article  CAS  PubMed  PubMed Central  Google Scholar 

Korley F, Diaz-Arrastia R, Wu A et al (2016) Circulating brain-derived neurotrophic factor has diagnostic and prognostic value in traumatic brain injury. J Neurotrauma 33:215–225. https://doi.org/10.1089/neu.2015.3949

Article  PubMed  PubMed Central  Google Scholar 

Cheng F, Yuan Q, Yang J, Wang W, Liu H (2014) The prognostic value of serum neuron-specific enolase in traumatic brain injury: systematic review and meta-analysis. PLoS One 9:e106680. https://doi.org/10.1371/journal.pone.0106680

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nakhjavan-Shahraki B, Yousefifard M, Oraii A, Sarveazad A, Hosseini M (2017) Meta-analysis of neuron specific enolase in predicting pediatric brain injury outcomes. EXCLI J 6:995–1008. https://doi.org/10.17179/excli2017-405

Article  Google Scholar 

Haque A, Ray S, Cox A, Banik N (2016) Neuron specific enolase: a promising therapeutic target in acute spinal cord injury. Metab Brain Dis 31:487–495. https://doi.org/10.1007/s11011-016-9801-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Papa L, Robertson C, Wang K, Brophy G, Hannay H, Heaton S, Schmalfuss I, Gabrielli A, Hayes R, Robicsek S (2015) Biomarkers improve clinical outcome predictors of mortality following non-penetrating severe traumatic brain injury. Neurocrit Care 22:52–64. https://doi.org/10.1007/s12028-014-0028-2

Article  CAS  PubMed  Google Scholar 

Rodríguez-Rodríguez A, Egea-Guerrero J, Gordillo-Escobar E et al (2016) S100B and neuron-specific enolase as mortality predictors in patients with severe traumatic brain injury. Neurol Res 38:130–137. https://doi.org/10.1080/01616412.2016.1144410

Article  CAS  PubMed  Google Scholar 

Jackson P, Thompson R (1981) The demonstration of new human brain-specific proteins by high-resolution two-dimensional polyacrylamide gel electrophoresis. J Neurol Sci 49:429–438. https://doi.org/10.1016/0022-510x(81)90032-0

Article  CAS  PubMed  Google Scholar 

Mondello S, Linnet A, Buki A et al (2012) Clinical utility of serum levels of ubiquitin C-terminal hydrolase as a biomarker for severe traumatic brain injury. Neurosurgery 70:666–675. https://doi.org/10.1227/NEU.0b013e318236a809

Article  PubMed  Google Scholar 

Setsuie R, Wada K (2007) The functions of UCH-L1 and its relation to neurodegenerative diseases. Neurochem Int 51:105–111. https://doi.org/10.1016/j.neuint.2007.05.007

Article  CAS  PubMed  Google Scholar 

Gong B, Leznik E (2007) The role of ubiquitin C-terminal hydrolase L1 in neurodegenerative disorders. Drug News Perspect 20:365–370. https://doi.org/10.1358/dnp.2007.20.6.1138160

Article  CAS  PubMed  Google Scholar 

Papa L, Akinyi L, Liu M et al (2010) Ubiquitin C-terminal hydrolase is a novel biomarker in humans for severe traumatic brain injury. Crit Care Med 38:138–144. https://doi.org/10.1097/CCM.0b013e3181b788ab

Article  CAS  PubMed  PubMed Central  Google Scholar 

Inagaki M, Nakamura Y, Takeda M, Nishimura T, Inagaki N (1994) Glial fibrillary acidic protein: dynamic property and regulation by phosphorylation. Brain Pathol 4:239–243. https://doi.org/10.1111/j.1750-3639.1994.tb00839.x

Article  CAS  PubMed  Google Scholar 

Lei J, Gao G, Feng J, Jin Y, Wang C, Mao Q, Jiang J (2015) Glial fibrillary acidic protein as a biomarker in severe traumatic brain injury patients: a prospective cohort study. Crit Care 19:362. https://doi.org/10.1186/s13054-015-1081-8

DeDominicis K, Hwang H, Cartagena C, Shear D, Boutté A (2003) Cerebrospinal fluid biomarkers are associated with glial fibrillary acidic protein and αII-spectrin breakdown products in brain tissues following penetrating ballistic-like brain injury in rats. Front Neurol 9:490. https://doi.org/10.3389/fneur.2018.00490

Article  Google Scholar 

Rothermundt M, Peters M, Prehn J, Arolt V (2003) S100B in brain damage and neurodegeneration. Microsc Res Tech 60:614–632. https://doi.org/10.1002/jemt.10303

Article  CAS  PubMed  Google Scholar 

Sorci G, Riuzzi F, Arcuri C, Tubaro C, Bianchi R, Giambanco I, Donato R (2013) S100B protein in tissue development, repair and regeneration. World J Biol Chem 4:1–12. https://doi.org/10.4331/wjbc.v4.i1.1

Article  PubMed  PubMed Central  Google Scholar 

Raabe A, Grolms C, Sorge O, Zimmermann M, Seifert V (1999) Serum S-100B protein in severe head injury. Neurosurgery 45:477–483. https://doi.org/10.1097/00006123-199909000-00012

Article  CAS  PubMed  Google Scholar 

Golden N, Mahadewa T, Aryanti C, Widyadharma I (2018) S100B serum level as a mortality predictor for traumatic brain injury: a meta-analysis. Open Access Maced J Med Sci 6:2239–2244. https://doi.org/10.3889/oamjms.2018.432

Article